Výsledky vyhledávání - "Lukas Trantirek"

Akademický článek

In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells

Autor: Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Šimon Džatko, Tomáš Loja, Martina Lenarčič Živković, Riccardo Rigo, Roberto El-Khoury, Israel Serrano-Chacón, Masad J. Damha, Carlos González, Jean-Louis Mergny, Silvie Foldynová-Trantírková, Lukáš Trantírek

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract I-Motifs (iM) are non-canonical DNA structures potentially forming in the accessible, single-stranded, cytosine-rich genomic regions with regulatory roles. Chromatin, protein interactions, and intracellular properties seem to govern iM forma

Externí odkaz: https://doaj.org/article/dccb82735cd744549a5a5749aaeca993

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Akademický článek

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

Dishevelled (DVL) is the key component of Wnt signaling pathway that acts as a signaling hub. Here, authors study the conformational dynamics of DVL3 in vivo using their engineered FlAsH-based FRET biosensors and describe how Wnt activation opens DVL

Externí odkaz: https://doaj.org/article/c656ec6d84244ea4ba47e39232d91995

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Akademický článek

One reporter for in-cell activity profiling of majority of protein kinase oncogenes

Autor: Iva Gudernova, Silvie Foldynova-Trantirkova, Barbora El Ghannamova, Bohumil Fafilek, Miroslav Varecha, Lukas Balek, Eva Hruba, Lucie Jonatova, Iva Jelinkova, Michaela Kunova Bosakova, Lukas Trantirek, Jiri Mayer, Pavel Krejci

Publikováno v: eLife, Vol 6 (2017)

In-cell profiling enables the evaluation of receptor tyrosine activity in a complex environment of regulatory networks that affect signal initiation, propagation and feedback. We used FGF-receptor signaling to identify EGR1 as a locus that strongly r

Externí odkaz: https://doaj.org/article/163ec228390542f9aefa419a66246f0b

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Akademický článek

Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle

Autor: Vera Slaninova, Michaela Krafcikova, Raquel Perez-Gomez, Pavel Steffal, Lukas Trantirek, Sarah J. Bray, Alena Krejci

Publikováno v: Open Biology, Vol 6, Iss 2 (2016)

Glycolytic shift is a characteristic feature of rapidly proliferating cells, such as cells during development and during immune response or cancer cells, as well as of stem cells. It results in increased glycolysis uncoupled from mitochondrial respir

Externí odkaz: https://doaj.org/article/caa9c31becee4fa58139b3bef62ed77b

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