Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lukas Steuernagel"'
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A. Bhat, Ananya S. Achanta, Joseph C. Johnson, Amanda Loren Pasqualini, Sanjana Jadhav, Corinna A. Bauder, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Azra Suko, Richard D. Palmiter, Miriam Stoeber, Peter Kloppenburg, Jens C. Brüning, Michael R. Bruchas, Tommaso Patriarchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action
Externí odkaz:
https://doaj.org/article/85f93020cae0443ca2de0481924bf37c
Autor:
Stephan Dodt, Noah V. Widdershooven, Marie-Luise Dreisow, Lisa Weiher, Lukas Steuernagel, F. Thomas Wunderlich, Jens C. Brüning, Henning Fenselau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous sig
Externí odkaz:
https://doaj.org/article/b77a139245084c57b73e0de421d41fff
Autor:
Stéphane Leon, Vincent Simon, Thomas H. Lee, Lukas Steuernagel, Samantha Clark, Nasim Biglari, Thierry Lesté-Lasserre, Nathalie Dupuy, Astrid Cannich, Luigi Bellocchio, Philippe Zizzari, Camille Allard, Delphine Gonzales, Yves Le Feuvre, Emeline Lhuillier, Alexandre Brochard, Jean Charles Nicolas, Jérémie Teillon, Macha Nikolski, Giovanni Marsicano, Xavier Fioramonti, Jens C. Brüning, Daniela Cota, Carmelo Quarta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to the neuroscience dogma,
Externí odkaz:
https://doaj.org/article/6a2e61e6730f4584b7b871ed0da5c413
Autor:
Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscur
Externí odkaz:
https://doaj.org/article/0ef32131373a4665897de31f813f7c3c
Autor:
Alain De Solis, Almudena Del Rio-Martin, Jan Radermacher, Weiyi Chen, Lukas Steuernagel, Corinna Bauder, Fynn Eggersmann, Ronald Morgan, Anna-Lena Cremer, Michael Sue, Stephan Vollmar, Heiko Backes, Kamal Rahmouni, Peter Kloppenburg, Jens Brüning
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S757- (2023)
Externí odkaz:
https://doaj.org/article/8b61319825c84bd3885478f3050d4cde
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake–promoting agouti related
Externí odkaz:
https://doaj.org/article/04d46d9f4e164c19a1ca885f921b9383
Autor:
Lukas Steuernagel, Cornelia Meckbach, Felix Heinrich, Sebastian Zeidler, Armin O Schmitt, Mehmet Gültas
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216475 (2019)
Transcription factors (TFs) are a special class of DNA-binding proteins that orchestrate gene transcription by recruiting other TFs, co-activators or co-repressors. Their combinatorial interplay in higher organisms maintains homeostasis and governs c
Externí odkaz:
https://doaj.org/article/b0bfe48c7f1d41eca4228cfbce1520c4
Development of a genetically-encoded sensor for probing endogenous nociceptin opioid peptide release
Autor:
Xuehan Zhou, Carrie Stine, Patricia Oliveira Prada, Debora Fusca, Kevin Assoumou, Jan Dernic, Musadiq A Bhat, Ananya S. Achanta, Joseph C Johnson, Sanjana Jadhav, Corinna A Bader, Lukas Steuernagel, Luca Ravotto, Dietmar Benke, Bruno Weber, Miriam Stoeber, Peter Kloppenburg, Jens Claus Bruening, Michael R Bruchas, Tommaso Patriarchi
Publikováno v:
bioRxiv
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e2c8ec895fdbf0b6b240626d49745f
https://europepmc.org/articles/PMC10245933/
https://europepmc.org/articles/PMC10245933/
Autor:
Zhuolei Jiao, Taosha Gao, Xiaofei Wang, Wen Zhang, Nasim Biglari, Emma E Boxer, Lukas Steuernagel, Xiaojing Ding, Zixian Yu, Mingjuan Li, Mingkun Hao, Hua Zhou, Xuanzi Cao, Shuaishuai Li, Tao Jiang, Jiamei Qi, Xueyan Jia, Zhao Feng, Biyu Ren, Yu Chen, Xiaoxue Shi, Dan Wang, Xinran Wang, Luyao Han, Yikai Liang, Congcong Wang, E Li, Yue Hu, Zi Tao, Humingzhu Li, Yu Xiang, Min Xu, Hung-Chun Chang, Yifeng Zhang, Hua-tai Xu, Jun Yan, Anan Li, Qingming Luo, Ron Stoop, Scott Sternson, Jens C. Bruning, Mu-ming Poo, David J Anderson, Hui Gong, Yangang Sun, Xiao-Hong Xu
The hypothalamus plays a vital role in coordinating essential neuroendocrine, autonomic, and somatomotor responses for survival and reproduction. While previous studies have explored population-level projections of hypothalamic neurons, the specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b3b166afcd00b1ee7c6a49be980f7b
https://doi.org/10.1101/2023.05.25.542241
https://doi.org/10.1101/2023.05.25.542241