Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lukas Stalder"'
Publikováno v:
F1000Research, Vol 9 (2020)
In academia, decisions on promotions are influenced by the citation impact of the works published by the candidates. The Medical Faculty of the University of Bern used a measure based on the journal impact factor (JIF) for this purpose: the JIF of th
Externí odkaz:
https://doaj.org/article/6f793fa870bc49bda7d653eebcfbae7b
Publikováno v:
PLoS Biology, Vol 6, Iss 4, p e92 (2008)
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the ter
Externí odkaz:
https://doaj.org/article/5a38530ef05d41228452597035c82031
Autor:
Tobias Hölscher, K. Khanfir, Helmut Kranzbühler, Stefanie Hayoz, Daniel R. Zwahlen, Pirus Ghadjar, Lukas Stalder, Daniel M. Aebersold, George N. Thalmann, Christiane Reuter, Matthias Guckenberger, Guido Hildebrandt, Vera Genitsch, Marcin Sumila, Paul Martin Putora, Volker Budach, Alexandros Papachristofilou, Christine Biaggi-Rudolf, Yousef Najafi, Ngwa C. Azinwi, Arndt-Christian Müller, Stephan Bodis, Piet Ost, Philipp Gut
Publikováno v:
BJU international. 120(5B)
OBJECTIVES: To conduct a central pathology review within a randomized clinical trial on salvage radiation therapy (RT) in the presence of biochemical recurrence after prostatectomy to assess whether this results in shifts of histopathological prognos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e3c2ec9a0b217f21a64ce54fdda947
https://pubmed.ncbi.nlm.nih.gov/29105993
https://pubmed.ncbi.nlm.nih.gov/29105993
Autor:
Oliver Mühlemann, Lukas Stalder
Publikováno v:
RNA
Nonsense-mediated mRNA decay (NMD) is a eukaryotic quality-control mechanism that recognizes and degrades mRNAs with premature termination codons (PTCs). In yeast, PTC-containing mRNAs are targeted to processing bodies (P-bodies), and yeast strains e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f797e623a6fc292df7a867ea875558a2
https://doi.org/10.1261/rna.1672509
https://doi.org/10.1261/rna.1672509
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779:538-549
Among the different cellular surveillance mechanisms in charge to prevent production of faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation-dependent posttranscriptional process that selectively recognizes and degrades m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07676c898801d91af0d5f7a552655ae
https://doi.org/10.1016/j.bbagrm.2008.06.012
https://doi.org/10.1016/j.bbagrm.2008.06.012
Autor:
Lukas Stalder, Oliver Mühlemann
Publikováno v:
Journal of Biological Chemistry. 282:16079-16085
Eukaryotes have evolved quality control mechanisms that prevent the expression of genes in which the protein coding potential is crippled by the presence of a premature translation-termination codon (PTC). In addition to nonsense-mediated mRNA decay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7791ad31257095243fde14027dad2dd0
https://doi.org/10.1074/jbc.m610595200
https://doi.org/10.1074/jbc.m610595200
Autor:
Christine Biaggi-Rudolf, Yousef Najafi, Tobias Hölscher, Daniel R. Zwahlen, Jürg Bernhard, Alexandros Papachristofilou, Pirus Ghadjar, Lukas Stalder, Guido Hildebrandt, Helmut Kranzbühler, Christiane Reuter, Ngwa C. Azinwi, Ludwig Plasswilm, Matthias Guckenberger, Daniel M. Aebersold, Marcin Sumila, Stefanie Hayoz, Stephan Bodis, Peter Wust, Piet Ost, Philipp Gut, Khanfir Kaouthar, George N. Thalmann, Arndt-Christian Müller
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(35)
Purpose Patients with biochemical failure (BF) after radical prostatectomy may benefit from dose-intensified salvage radiation therapy (SRT) of the prostate bed. We performed a randomized phase III trial assessing dose intensification. Patients and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c735c22b211e6dcf71660bde10c3375d
https://pubmed.ncbi.nlm.nih.gov/27301993
https://pubmed.ncbi.nlm.nih.gov/27301993
Publikováno v:
Molecular Cell. 18(3):307-317
Cells possess mechanisms to prevent synthesis of potentially deleterious truncated proteins caused by premature translation-termination codons (PTCs). Here, we show that PTCs can induce silencing of transcription of its cognate gene. We demonstrate f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd947c918c6c23c46d092eae8c7167e6
Autor:
Elisabeth Oppliger Leibundgut, Christiane Pilop, Daniel Rauch, Adrian F. Ochsenbein, Lukas Bubendorf, Solange Peters, Spasenija Savic, Jonas Feilchenfeldt, Martin Früh, Oliver Gautschi, Alfred Zippelius, Richard Cathomas, Rolf Jaggi, Martin Brutsche, Qiyu Li, Lukas Stalder, Rolf A. Stahel, Carlo R. Largiadèr, Daniel Betticher, N. Mach, Miklos Pless, Sacha I. Rothschild
Publikováno v:
Clinical lung cancer. 16(5)
Treatment allocation by epidermal growth factor receptor mutation status is a new standard in patients with metastatic nonesmall-cell lung cancer. Yet, relatively few modern chemotherapy trials were conducted in patients characterized by epidermal gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed4ee3781063247e6013dfae8a8a988
https://pubmed.ncbi.nlm.nih.gov/25843489
https://pubmed.ncbi.nlm.nih.gov/25843489
Autor:
Martin Hintersteiner, Justin Hean, Nicole Meisner-Kober, Florian Aeschimann, David V. Morrissey, Lukas Stalder, Pascal Basselet, Anja Fritzsche, Lena Sokol, Dominic Trojer, Vera Pfanzagl, Jan Weiler, Joel Wirz, Wolf Heusermann
Publikováno v:
The EMBO Journal
Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show that loading of lipid-transfected siRNAs and endogenous microRNAs (miRNA) into RISC (RNA-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f995fb5adc669836efa3da890120b1
https://pubmed.ncbi.nlm.nih.gov/23511973
https://pubmed.ncbi.nlm.nih.gov/23511973