Výsledky vyhledávání - "Lukas Schimunek"

Akademický článek

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes

Autor: Lukas Schimunek, Haley Lindberg, Maria Cohen, Rami A. Namas, Qi Mi, Jinling Yin, Derek Barclay, Fayten El-Dehaibi, Andrew Abboud, Ruben Zamora, Timothy Robert Billiar, Yoram Vodovotz

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Systemic inflammation ensues following traumatic injury, driving immune dysregulation and multiple organ dysfunction (MOD). While a balanced immune/inflammatory response is ideal for promoting tissue regeneration, most trauma patients exhibit variabl

Externí odkaz: https://doaj.org/article/47a5bf8f328d42819b0b0f381a9e8e1a

Zobrazit plný text záznamu

Akademický článek

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes

Autor: Lukas Schimunek, Rami A. Namas, Jinling Yin, Derek Barclay, Dongmei Liu, Fayten el-Dehaibi, Andrew Abboud, Maria Cohen, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

Trauma is a leading cause of morbidity and mortality. It is unclear why some trauma victims follow a complicated clinical course and die, while others, with apparently similar injury characteristics, do not. Interpatient genomic differences, in the f

Externí odkaz: https://doaj.org/article/6fb0e64f2e3c4b7383c5b79717dfc222

Zobrazit plný text záznamu

Akademický článek

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice.

Autor: Ruben Zamora, Sebastian Korff, Qi Mi, Derek Barclay, Lukas Schimunek, Riccardo Zucca, Xerxes D Arsiwalla, Richard L Simmons, Paul Verschure, Timothy R Billiar, Yoram Vodovotz

Publikováno v: PLoS Computational Biology, Vol 14, Iss 11, p e1006582 (2018)

Bacterial lipopolysaccharide (LPS) induces an acute inflammatory response across multiple organs, primarily via Toll-like receptor 4 (TLR4). We sought to define novel aspects of the complex spatiotemporal dynamics of LPS-induced inflammation using co

Externí odkaz: https://doaj.org/article/2c79d14110ca4cbabb9e7f8fb7d266e2

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Comparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytrauma

Autor: Rafael Serve, Ramona Sturm, Lukas Schimunek, Philipp Störmann, David Heftrig, Michel P. J. Teuben, Elsie Oppermann, Klemens Horst, Roman Pfeifer, Tim P. Simon, Yannik Kalbas, Hans-Christoph Pape, Frank Hildebrand, Ingo Marzi, Borna Relja

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

BackgroundSeverely injured patients experience substantial immunological stress in the aftermath of traumatic insult, which often results in systemic immune dysregulation. Regulatory T cells (Treg) play a key role in the suppression of the immune res

Externí odkaz: https://doaj.org/article/003abc32d8ff4e1bb8e3a8633b97fa78

Zobrazit plný text záznamu

Akademický článek

Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model.

Autor: Lukas Schimunek, Rafael Serve, Michel P J Teuben, Philipp Störmann, Birgit Auner, Mathias Woschek, Roman Pfeifer, Klemens Horst, Tim-P Simon, Miriam Kalbitz, Ramona Sturm, Hans-C Pape, Frank Hildebrand, Ingo Marzi, Borna Relja

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187404 (2017)

In their post-traumatic course, trauma patients suffering from multiple injuries have a high risk for immune dysregulation, which may contribute to post-injury complications and late mortality. Monocytes as specific effector cells of the innate immun

Externí odkaz: https://doaj.org/article/ad3ea3f33df44c558db1d9a0dee80336

Zobrazit plný text záznamu

Akademický článek

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients

Autor: David Heftrig, Ramona Sturm, Elsie Oppermann, Kerstin Kontradowitz, Katrin Jurida, Lukas Schimunek, Mathias Woschek, Ingo Marzi, Borna Relja

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

Objective. Trauma patients (TP) frequently develop an imbalanced immune response that often causes infectious postinjury complications. Monocytes show a diminished capability of both producing proinflammatory cytokines and antigen presentation after

Externí odkaz: https://doaj.org/article/5a033a515149485e92c4c874aee1d015

Zobrazit plný text záznamu

Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness

Autor: Timothy R. Billiar, Rami A. Namas, Fayten El-Dehaibi, Maria Cohen, Yoram Vodovotz, Yan Xu, Ashley J. Lamparello, A. Kaynar, Lukas Schimunek

Publikováno v: Shock

Acute illness is a complex constellation of responses involving dysregulated inflammatory and immune responses, which are ultimately associated with multiple organ dysfunction. Gene association studies have associated single-nucleotide polymorphisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb25858b25560f9b280afa150524605
https://doi.org/10.1097/shk.0000000000001409

Zobrazit plný text záznamu

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma

Autor: Ruben Zamora, Lukas Schimunek, Timothy R. Billiar, Rami A. Namas, Haley Lindberg, Yoram Vodovotz, Andrew Abboud, Dongmei Liu, Jinling Yin, Fayten El-Dehaibi, Derek Barclay

Publikováno v: Shock. 49:259-268

Trauma is the leading cause of death worldwide for individuals under the age of 55. Interpatient genomic differences, in the form of candidate single-nucleotide polymorphisms (SNPs), have been associated previously with adverse outcomes after trauma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5617c27fbf00d525b3970aa1b36ba00
https://doi.org/10.1097/shk.0000000000000987

Zobrazit plný text záznamu

Autor: Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz, Fayten El-Dehaibi, Rami A. Namas, Ashley J. Lamparello, Derek Barclay, Lukas Schimunek, Jinling Yin, Maria Cohen

Publikováno v: Shock

The contribution of individual genetic determinants of aging to the adverse clinical outcomes and altered inflammation mediator networks characteristic of aged trauma patients is unknown. The AA genotype of the aging-related single-nucleotide polymor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a481a5a7565ced277ede87ce2063893f
https://pubmed.ncbi.nlm.nih.gov/31318836

Zobrazit plný text záznamu

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients

Autor: Lukas Schimunek, Katrin Jurida, David Heftrig, Mathias Woschek, Ramona Sturm, Kerstin Kontradowitz, Borna Relja, Elsie Oppermann, Ingo Marzi

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2017 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d12e9952855a681ea9a2bb47b975f
http://europepmc.org/articles/PMC5309437

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání