Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Autor: Steven Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, Jeroen Esselink, Allard van Egmond, Jornt Mos, Joost B. Beltman, Jens Timmer, Bob van de Water, Daniel Kaschek

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeost

Externí odkaz: https://doaj.org/article/15080c2445a249f3aa5307f2274fe4e7

Model-based translation of DNA damage signaling dynamics across cell types.

Autor: Muriel M Heldring, Lukas S Wijaya, Marije Niemeijer, Huan Yang, Talel Lakhal, Sylvia E Le Dévédec, Bob van de Water, Joost B Beltman

Publikováno v: PLoS Computational Biology, Vol 18, Iss 7, p e1010264 (2022)

Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR d

Externí odkaz: https://doaj.org/article/bd05827ec19846e2a4c97f9f4699496c

Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

Autor: Joost B. Beltman, Hennicke Kamp, Jan G. Hengstler, Bob van de Water, Matthijs Vlasveld, Lukas S Wijaya, Vincent Spegg, Theresa Braun, Stefan Schildknecht, Serif Marangoz, Marcel Leist, Carina Rau, Wiebke Albrecht, Tim Brecklinghaus

Publikováno v: Cell Biology and Toxicology
Cell biology and toxicology, 38(5):847–864

Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9829de62726c32b80524c469f30939
https://doi.org/10.1007/s10565-021-09610-3

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

Autor: Hans den Dulk, Reina E Mebius, Eva J. van Rooden, Hans van den Elst, Pasquale C Putter, Bob van de Water, Else Botter, Gerard J. P. van Westen, Alexander T Bakker, Vera E. van der Noord, Bogdan I. Florea, Mario van der Stelt, Kim Wals, Sylvia E. Le Dévédec, Sebastiaan T A Koenders, Herman S. Overkleeft, Lukas S Wijaya, Martje N. Erkelens, Lindsey Burggraaff

Publikováno v: ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
ACS Central Science, 5(12), 1965-1974
ACS Central Science, 5(12), 1965-1974. American Chemical Society
ACS Central Science
Koenders, S T A, Wijaya, L S, Erkelens, M N, Bakker, A T, van der Noord, V E, van Rooden, E J, Burggraaff, L, Putter, P C, Botter, E, Wals, K, van den Elst, H, den Dulk, H, Florea, B I, van de Water, B, van Westen, G J P, Mebius, R E, Overkleeft, H S, Le Dévédec, S E & van der Stelt, M 2019, ' Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells ', ACS Central Science, vol. 5, no. 12, pp. 1965-1974 . https://doi.org/10.1021/acscentsci.9b01022

Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and methods are of great utility to visualize and quantify aldehyde dehydrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b18f0ce494d673ba0a4dba8ef3c0464
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017

Data-driven computational modeling of the DNA damage response and liver toxicity

Autor: M Heldring, Lukas S Wijaya, S. E. Le Devedec, Joost B. Beltman, T Lakhal, B. van de Water

Publikováno v: Toxicology Letters. 350:S28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80230dc1e8c0ff4e0574d24e758019ea
https://doi.org/10.1016/s0378-4274(21)00305-2