Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Lukas S, Wijaya"'
1
Akademický článek
Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure
Autor: Steven Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, Jeroen Esselink, Allard van Egmond, Jornt Mos, Joost B. Beltman, Jens Timmer, Bob van de Water, Daniel Kaschek
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeost
Externí odkaz: https://doaj.org/article/15080c2445a249f3aa5307f2274fe4e7
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2
Akademický článek
Model-based translation of DNA damage signaling dynamics across cell types.
Autor: Muriel M Heldring, Lukas S Wijaya, Marije Niemeijer, Huan Yang, Talel Lakhal, Sylvia E Le Dévédec, Bob van de Water, Joost B Beltman
Publikováno v: PLoS Computational Biology, Vol 18, Iss 7, p e1010264 (2022)
Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR d
Externí odkaz: https://doaj.org/article/bd05827ec19846e2a4c97f9f4699496c
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5
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
Autor: Joost B. Beltman, Hennicke Kamp, Jan G. Hengstler, Bob van de Water, Matthijs Vlasveld, Lukas S Wijaya, Vincent Spegg, Theresa Braun, Stefan Schildknecht, Serif Marangoz, Marcel Leist, Carina Rau, Wiebke Albrecht, Tim Brecklinghaus
Publikováno v: Cell Biology and Toxicology
Cell biology and toxicology, 38(5):847–864
Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intrace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9829de62726c32b80524c469f30939
https://doi.org/10.1007/s10565-021-09610-3
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6
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid
Autor: Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
Publikováno v: ALTEX : Alternatives to Animal Experimentation
ALTEX
Chemical read-across is commonly evaluated without particular knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will strengthen read-across cases. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2256765890ee51972b634035aa790
http://hdl.handle.net/1887/3279365
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7
Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells
Autor: Hans den Dulk, Reina E Mebius, Eva J. van Rooden, Hans van den Elst, Pasquale C Putter, Bob van de Water, Else Botter, Gerard J. P. van Westen, Alexander T Bakker, Vera E. van der Noord, Bogdan I. Florea, Mario van der Stelt, Kim Wals, Sylvia E. Le Dévédec, Sebastiaan T A Koenders, Herman S. Overkleeft, Lukas S Wijaya, Martje N. Erkelens, Lindsey Burggraaff
Publikováno v: ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
ACS Central Science, 5(12), 1965-1974
ACS Central Science, 5(12), 1965-1974. American Chemical Society
ACS Central Science
Koenders, S T A, Wijaya, L S, Erkelens, M N, Bakker, A T, van der Noord, V E, van Rooden, E J, Burggraaff, L, Putter, P C, Botter, E, Wals, K, van den Elst, H, den Dulk, H, Florea, B I, van de Water, B, van Westen, G J P, Mebius, R E, Overkleeft, H S, Le Dévédec, S E & van der Stelt, M 2019, ' Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells ', ACS Central Science, vol. 5, no. 12, pp. 1965-1974 . https://doi.org/10.1021/acscentsci.9b01022
Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and methods are of great utility to visualize and quantify aldehyde dehydrog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b18f0ce494d673ba0a4dba8ef3c0464
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017
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8
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury
Autor: Ariadna Alcalà Morera, Attila Gábor, Huan Yang, Stefan Schildknecht, Julio Saez-Rodriguez, Hennicke Kamp, Sylvia E. Le Dévédec, Peter Bouwman, Marcel Leist, Jan G. Hengstler, Joost B. Beltman, Panuwat Trairatphisan, Bob van de Water, Kirsten E. Snijders, Jason Keet, Marije Niemeijer, Lukas S Wijaya, James L. Stevens, Steven Wink
Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, 190
Biochemical pharmacology, 190:114591
Drug-induced liver injury (DILI) is the most prevalent adversity encountered in drug development and clinical settings leading to urgent needs to understand the underlying mechanisms. In this study, we have systematically investigated the dynamics of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381c7cd9b5f7fb2375f99d72a85e5071
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