Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Lukas P. Frenzel"'
Autor:
Othman Al-Sawaf, Can Zhang, Hyun Yong Jin, Sandra Robrecht, Yoonha Choi, Sandhya Balasubramanian, Alex Kotak, Yi Meng Chang, Anna Maria Fink, Eugen Tausch, Christof Schneider, Matthias Ritgen, Karl-Anton Kreuzer, Brenda Chyla, Joseph N. Paulson, Christian P. Pallasch, Lukas P. Frenzel, Martin Peifer, Barbara Eichhorst, Stephan Stilgenbauer, Yanwen Jiang, Michael Hallek, Kirsten Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Data on long-term outcomes and biological drivers associated with depth of remission after BCL2 inhibition by venetoclax in the treatment of chronic lymphocytic leukemia (CLL) are limited. In this open-label parallel-group phase-3 study, 432
Externí odkaz:
https://doaj.org/article/c127bbfa3a4040329f269c6323da0d06
Autor:
Othman Al-Sawaf, Can Zhang, Hyun Yong Jin, Sandra Robrecht, Yoonha Choi, Sandhya Balasubramanian, Alex Kotak, Yi Meng Chang, Anna Maria Fink, Eugen Tausch, Christof Schneider, Matthias Ritgen, Karl-Anton Kreuzer, Brenda Chyla, Joseph N. Paulson, Christian P. Pallasch, Lukas P. Frenzel, Martin Peifer, Barbara Eichhorst, Stephan Stilgenbauer, Yanwen Jiang, Michael Hallek, Kirsten Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c77836ed356f4db6a5fa3d2f59504785
Autor:
Carmen D. Herling, Nima Abedpour, Jonathan Weiss, Anna Schmitt, Ron Daniel Jachimowicz, Olaf Merkel, Maria Cartolano, Sebastian Oberbeck, Petra Mayer, Valeska Berg, Daniel Thomalla, Nadine Kutsch, Marius Stiefelhagen, Paula Cramer, Clemens-Martin Wendtner, Thorsten Persigehl, Andreas Saleh, Janine Altmüller, Peter Nürnberg, Christian Pallasch, Viktor Achter, Ulrich Lang, Barbara Eichhorst, Roberta Castiglione, Stephan C. Schäfer, Reinhard Büttner, Karl-Anton Kreuzer, Hans Christian Reinhardt, Michael Hallek, Lukas P. Frenzel, Martin Peifer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
BCL2-inhibitor venetoclax is used to treat relapsed/refractory chronic lymphocytic leukemia (CLL). Here, the authors show the clonal dynamics towards venetoclax resistance by performing whole-exome sequencing of 8 CLL patients undergoing venetoclax t
Externí odkaz:
https://doaj.org/article/91cad87502c5439c87643a607b72a378
Autor:
Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling, Carmen Herling, Jasmin Bahlo, Michael Hallek, Martin Peifer, Reinhard Buettner, Thorsten Persigehl, H. Christian Reinhardt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is s
Externí odkaz:
https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Externí odkaz:
https://doaj.org/article/20158e4a37a44f44bda43dbc8bc44c5d
Autor:
Othman Al-Sawaf, Carmen Diana Herling, Udo Holtick, Christoph Scheid, Paula Cramer, Stephanie Sasse, Bastian von Tresckow, Armin Tuchscherer, Kirsten Fischer, Barbara Eichhorst, Michael Hallek, Lukas P. Frenzel
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Externí odkaz:
https://doaj.org/article/10943b4899fc4b2abeb8cfcf0aa56e71
Autor:
Gero Knittel, Hans Christian Reinhardt, Clemens A. Schmitt, Martin Peifer, Thorsten Persigehl, Anthony Letai, Arndt Borkhardt, Hamid Kashkar, Reinhard Büttner, Philipp Lohneis, Anna Brunn, Manuel Montesinos-Rongen, Sandrine Sander, Ari M. Melnick, Wendy Béguelin, Laura Pasqualucci, Lukas P. Frenzel, Andreas R. Klatt, Janine Altmüller, Martina Deckert, Marcus Krüger, Janica Wiederstein, Arina Riabinska, Maurice Reimann, Jeremy A. Ryan, Alexandra da Palma Guerreiro, Julia Hauer, Heinz Ahlert, Benedikt W. Pelzer, Ilmars Kisis, Moritz Kochanek, Sanil Bhatia, Sebastian Klein, Alessandra Holzem, Pauline Pfeiffer, Pascal Nieper, Tim Rehkämper, Ruth Flümann
Pharmacological Screen IC50 values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b24c0c678d7d5feb1dbbae1529f6df7
https://doi.org/10.1158/2643-3230.22542673
https://doi.org/10.1158/2643-3230.22542673
Autor:
Gero Knittel, Hans Christian Reinhardt, Clemens A. Schmitt, Martin Peifer, Thorsten Persigehl, Anthony Letai, Arndt Borkhardt, Hamid Kashkar, Reinhard Büttner, Philipp Lohneis, Anna Brunn, Manuel Montesinos-Rongen, Sandrine Sander, Ari M. Melnick, Wendy Béguelin, Laura Pasqualucci, Lukas P. Frenzel, Andreas R. Klatt, Janine Altmüller, Martina Deckert, Marcus Krüger, Janica Wiederstein, Arina Riabinska, Maurice Reimann, Jeremy A. Ryan, Alexandra da Palma Guerreiro, Julia Hauer, Heinz Ahlert, Benedikt W. Pelzer, Ilmars Kisis, Moritz Kochanek, Sanil Bhatia, Sebastian Klein, Alessandra Holzem, Pauline Pfeiffer, Pascal Nieper, Tim Rehkämper, Ruth Flümann
Based on gene expression profiles, diffuse large B-cell lymphoma (DLBCL) is subdivided into germinal center B-cell–like (GCB) and activated B-cell–like (ABC) DLBCL. Two of the most common genomic aberrations in ABC-DLBCL are mutations in MYD88 as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be2bb69b8adfd9f6af9c3c822eed536
https://doi.org/10.1158/2643-3230.c.6550018
https://doi.org/10.1158/2643-3230.c.6550018
Autor:
Gero Knittel, Hans Christian Reinhardt, Clemens A. Schmitt, Martin Peifer, Thorsten Persigehl, Anthony Letai, Arndt Borkhardt, Hamid Kashkar, Reinhard Büttner, Philipp Lohneis, Anna Brunn, Manuel Montesinos-Rongen, Sandrine Sander, Ari M. Melnick, Wendy Béguelin, Laura Pasqualucci, Lukas P. Frenzel, Andreas R. Klatt, Janine Altmüller, Martina Deckert, Marcus Krüger, Janica Wiederstein, Arina Riabinska, Maurice Reimann, Jeremy A. Ryan, Alexandra da Palma Guerreiro, Julia Hauer, Heinz Ahlert, Benedikt W. Pelzer, Ilmars Kisis, Moritz Kochanek, Sanil Bhatia, Sebastian Klein, Alessandra Holzem, Pauline Pfeiffer, Pascal Nieper, Tim Rehkämper, Ruth Flümann
Figures S1 - S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07095ca1356e2aa915992e51cd1bcf4a
https://doi.org/10.1158/2643-3230.22542679.v1
https://doi.org/10.1158/2643-3230.22542679.v1
Autor:
Christoph Plass, Clemens-Martin Wendtner, John C. Byrd, Michael Rehli, Esther Herpel, Christian Philipp Pallasch, Martina Fischer, Dieter Weichenhan, Lei Gu, Yoon Jung Park, Manuela Zucknick, Lukas P. Frenzel, Rainer Claus, Constance Baer
PDF file - 166K, Table S3 contains all putative promoter regions as determined by H3K4me3 enrichment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa5b2f2a0de995938c2941c8dd7332f
https://doi.org/10.1158/0008-5472.22394198
https://doi.org/10.1158/0008-5472.22394198