Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lukas Opalka"'
Autor:
Fabio Strati, Tetiana Mukhina, Reinhard H.H. Neubert, Lukas Opalka, Gerd Hause, Christian E.H. Schmelzer, Matthias Menzel, Gerald Brezesinski
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100039- (2022)
The stratum corneum (SC) is the largest physical barrier of the human body. It protects against physical, chemical and biological damages, and avoids evaporation of water from the deepest skin layers. For its correct functioning, the homeostasis of t
Externí odkaz:
https://doaj.org/article/535c73ac2bd0430bbea09ddd8c6c80b0
Publikováno v:
Mass Spectrometry for Lipidomics. :425-480
Autor:
Kristýna Hergesell, Anna Paraskevopoulou, Lukáš Opálka, Vladimír Velebný, Kateřina Vávrová, Iva Dolečková
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood. Here, we studied the changes in selected ep
Externí odkaz:
https://doaj.org/article/8e4c4ef10093417780237198a177108d
Autor:
Ferdinand Fandrei, Tomáš Havrišák, Lukáš Opálka, Oskar Engberg, Albert A. Smith, Petra Pullmannová, Norbert Kučerka, Veronika Ondrejčeková, Bruno Demé, Lucie Nováková, Miloš Steinhart, Kateřina Vávrová, Daniel Huster
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100356- (2023)
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances. These ceramides dri
Externí odkaz:
https://doaj.org/article/d2014d3735294b249f6d211ee7a94412
Autor:
Lukáš Opálka, Jason M. Meyer, Veronika Ondrejčeková, Linda Svatošová, Franz P.W. Radner, Kateřina Vávrová
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100226- (2022)
Epidermal omega-O-acylceramides (ω-O-acylCers) are essential components of a competent skin barrier. These unusual sphingolipids with ultralong N-acyl chains contain linoleic acid esterified to the terminal hydroxyl of the N-acyl, the formation of w
Externí odkaz:
https://doaj.org/article/d13d2c5056fd453094f7987456a7a7e4
Autor:
Ferdinand Fandrei, Oskar Engberg, Lukáš Opálka, Pavla Jančálková, Petra Pullmannová, Miloš Steinhart, Andrej Kováčik, Kateřina Vávrová, Daniel Huster
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100177- (2022)
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function. The CholS/Chol ratio decreases during SC maturation but remains high in pathologi
Externí odkaz:
https://doaj.org/article/f98fb2f99c964079aa07c4c1ef4058a2
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 219-228 (2020)
Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentra
Externí odkaz:
https://doaj.org/article/dd4696fe78774b1bafd19ba680ebb228
Autor:
Johanna von Gerichten, Dominic Lamprecht, Lukáš Opálka, Daphnée Soulard, Christian Marsching, Robert Pilz, Valentin Sencio, Silke Herzer, Bruno Galy, Viola Nordström, Carsten Hopf, Hermann-Josef Gröne, François Trottein, Roger Sandhoff
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1892-1904 (2019)
The glycosphingolipid, α-galactosylceramide (αGalCer), when presented by CD1d on antigen-presenting cells, efficiently activates invariant natural killer T (iNKT) cells. Thereby, it modulates immune responses against tumors, microbial and viral inf
Externí odkaz:
https://doaj.org/article/916935eb800d4a97908209492b1d14ed
Autor:
Petra Pullmannová, Elena Ermakova, Andrej Kováčik, Lukáš Opálka, Jaroslav Maixner, Jarmila Zbytovská, Norbert Kučerka, Kateřina Vávrová
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 963-971 (2019)
Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O-a
Externí odkaz:
https://doaj.org/article/ea4584eac098420fb349a0b5aa2e5013
Autor:
Andrej Kováčik, Petra Pullmannová, Lukáš Opálka, Michaela Šilarová, Jaroslav Maixner, Kateřina Vávrová
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7468 (2021)
Ceramides (Cers) with α-hydroxylated acyl chains comprise about a third of all extractable skin Cers and are required for permeability barrier homeostasis. We have probed here the effects of Cer hydroxylation on their behavior in lipid models compri
Externí odkaz:
https://doaj.org/article/a19bbe08947642c8af95f01768ffce09