Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Lukas M Simon"'
Autor:
Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-22 (2021)
Abstract The correspondence of cell state changes in diseased organs to peripheral protein signatures is currently unknown. Here, we generated and integrated single‐cell transcriptomic and proteomic data from multiple large pulmonary fibrosis patie
Externí odkaz:
https://doaj.org/article/85b58d714e3046fa9fc4ca873ca79252
Autor:
Toshiyuki Itai, Fangfang Yan, Andi Liu, Yulin Dai, Chihiro Iwaya, Sarah W. Curtis, Elizabeth J. Leslie, Lukas M. Simon, Peilin Jia, Xiangning Chen, Junichi Iwata, Zhongming Zhao
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100313- (2024)
Summary: Orofacial clefts (OFCs) are common congenital birth defects with various etiologies, including genetic variants. Online Mendelian Inheritance in Man (OMIM) annotated several hundred genes involving OFCs. Furthermore, several hundreds of de n
Externí odkaz:
https://doaj.org/article/d1da2bc8f18746018552c2282332f15a
Autor:
Yulin Dai, Toshiyuki Itai, Guangsheng Pei, Fangfang Yan, Yan Chu, Xiaoqian Jiang, Seth M. Weinberg, Nandita Mukhopadhyay, Mary L. Marazita, Lukas M. Simon, Peilin Jia, Zhongming Zhao
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100312- (2024)
Summary: Orofacial clefts (OFCs) are among the most common human congenital birth defects. Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP). Alth
Externí odkaz:
https://doaj.org/article/1674e572859a430fb03d3eef41dde83f
Autor:
Fangfang Yan, Vivian Jiang, Alexa Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yu Xue, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Lei Nie, Yixin Yao, Heng-Huan Lee, Wei Wang, JohnNelson R. Bigcal, Maria Badillo, Jitendra Meena, Christopher Flowers, Jia Zhou, Zhongming Zhao, Lukas M. Simon, Michael Wang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Brexucabtagene autoleucel CAR-T therapy is highly efficacious in overcoming resistance to Bruton’s tyrosine kinase inhibitors (BTKi) in mantle cell lymphoma. However, many patients relapse post CAR-T therapy with dismal outcomes. To dissec
Externí odkaz:
https://doaj.org/article/beeb6ae7b6d9445bbe125ff723c876c2
Autor:
Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is among the most common congenital birth defects. Here, we perform single-cell multiome sequencing and profile chromatin accessibility and gene expression
Externí odkaz:
https://doaj.org/article/6cd15382d2174b2486bc7b4a4b70cba7
Autor:
Lukas M. Simon, Cecilia Flocco, Franziska Burkart, Anika Methner, David Henke, Luise Rauer, Christian L. Müller, Johannes Vogel, Christiane Quaisser, Jörg Overmann, Stefan Simon
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107578- (2023)
Summary: Microbial communities reside at the interface between humans and their environment. Whether the microbiome can be leveraged to gain information on human interaction with museum objects is unclear. To investigate this, we selected objects fro
Externí odkaz:
https://doaj.org/article/fb5a93230a854ffd807ff17bf72dea32
Autor:
Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao
SUMMARYThe abnormal perturbation in gene regulation during palatogenesis may lead to cleft palate, a major congenital birth defect in humans and mice. However, a comprehensive multi-omic map of the developing secondary palate at single-cell resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3dcccb1c8970b32877aa5f5581a47ee
https://doi.org/10.1101/2022.11.02.514609
https://doi.org/10.1101/2022.11.02.514609
Publikováno v:
Nature Machine Intelligence. 3:705-715
Efficient integration of heterogeneous and increasingly large single-cell RNA sequencing data poses a major challenge for analysis and, in particular, comprehensive atlasing efforts. Here we developed a novel deep learning algorithm called INSCT (Ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe588a974e575cc1644f8047ee331635
https://doi.org/10.1038/s42256-021-00361-8
https://doi.org/10.1038/s42256-021-00361-8
Autor:
Kui Hong, Lukas M. Simon, Leila Rouhi, Sirisha Cheedipudi, Siyang Fan, Ping Yuan, Ali J. Marian, Priyatansh Gurha, Zhongming Zhao
Publikováno v:
Circulation
Background: Arrhythmogenic cardiomyopathy (ACM) manifests with sudden death, arrhythmias, heart failure, apoptosis, and myocardial fibro-adipogenesis. The phenotype typically starts at the epicardium and advances transmurally. Mutations in genes enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43fe2b4733d99accb95ee4efca0a560
https://doi.org/10.1161/circulationaha.120.052928
https://doi.org/10.1161/circulationaha.120.052928
Autor:
Vivian Changying Jiang, Fangfang Yan, Alexa A Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Yixin Yao, Heng-Huan Lee, Jingling Jin, Wei Wang, Lei Nie, Zhongming Zhao, Lukas M Simon, Michael L. Wang
Publikováno v:
Blood. 140:3512-3513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a20d81e104742fa4efd8f5e781f0467
https://doi.org/10.1182/blood-2022-163696
https://doi.org/10.1182/blood-2022-163696