Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Lukas M Simon"'
Autor:
Toshiyuki Itai, Fangfang Yan, Andi Liu, Yulin Dai, Chihiro Iwaya, Sarah W. Curtis, Elizabeth J. Leslie, Lukas M. Simon, Peilin Jia, Xiangning Chen, Junichi Iwata, Zhongming Zhao
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100313- (2024)
Summary: Orofacial clefts (OFCs) are common congenital birth defects with various etiologies, including genetic variants. Online Mendelian Inheritance in Man (OMIM) annotated several hundred genes involving OFCs. Furthermore, several hundreds of de n
Externí odkaz:
https://doaj.org/article/d1da2bc8f18746018552c2282332f15a
Autor:
Yulin Dai, Toshiyuki Itai, Guangsheng Pei, Fangfang Yan, Yan Chu, Xiaoqian Jiang, Seth M. Weinberg, Nandita Mukhopadhyay, Mary L. Marazita, Lukas M. Simon, Peilin Jia, Zhongming Zhao
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100312- (2024)
Summary: Orofacial clefts (OFCs) are among the most common human congenital birth defects. Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP). Alth
Externí odkaz:
https://doaj.org/article/1674e572859a430fb03d3eef41dde83f
Autor:
Fangfang Yan, Vivian Jiang, Alexa Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yu Xue, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Lei Nie, Yixin Yao, Heng-Huan Lee, Wei Wang, JohnNelson R. Bigcal, Maria Badillo, Jitendra Meena, Christopher Flowers, Jia Zhou, Zhongming Zhao, Lukas M. Simon, Michael Wang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Brexucabtagene autoleucel CAR-T therapy is highly efficacious in overcoming resistance to Bruton’s tyrosine kinase inhibitors (BTKi) in mantle cell lymphoma. However, many patients relapse post CAR-T therapy with dismal outcomes. To dissec
Externí odkaz:
https://doaj.org/article/beeb6ae7b6d9445bbe125ff723c876c2
Autor:
Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is among the most common congenital birth defects. Here, we perform single-cell multiome sequencing and profile chromatin accessibility and gene expression
Externí odkaz:
https://doaj.org/article/6cd15382d2174b2486bc7b4a4b70cba7
Autor:
Lukas M. Simon, Cecilia Flocco, Franziska Burkart, Anika Methner, David Henke, Luise Rauer, Christian L. Müller, Johannes Vogel, Christiane Quaisser, Jörg Overmann, Stefan Simon
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107578- (2023)
Summary: Microbial communities reside at the interface between humans and their environment. Whether the microbiome can be leveraged to gain information on human interaction with museum objects is unclear. To investigate this, we selected objects fro
Externí odkaz:
https://doaj.org/article/fb5a93230a854ffd807ff17bf72dea32
Autor:
Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-22 (2021)
Abstract The correspondence of cell state changes in diseased organs to peripheral protein signatures is currently unknown. Here, we generated and integrated single‐cell transcriptomic and proteomic data from multiple large pulmonary fibrosis patie
Externí odkaz:
https://doaj.org/article/85b58d714e3046fa9fc4ca873ca79252
Autor:
Maximilian Strunz, Lukas M. Simon, Meshal Ansari, Jaymin J. Kathiriya, Ilias Angelidis, Christoph H. Mayr, George Tsidiridis, Marius Lange, Laura F. Mattner, Min Yee, Paulina Ogar, Arunima Sengupta, Igor Kukhtevich, Robert Schneider, Zhongming Zhao, Carola Voss, Tobias Stoeger, Jens H. L. Neumann, Anne Hilgendorff, Jürgen Behr, Michael O’Reilly, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff, Harold A. Chapman, Fabian J. Theis, Herbert B. Schiller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell sta
Externí odkaz:
https://doaj.org/article/c56bf52cb142499c98ef8cc384553dbe
Autor:
Ilias Angelidis, Lukas M. Simon, Isis E. Fernandez, Maximilian Strunz, Christoph H. Mayr, Flavia R. Greiffo, George Tsitsiridis, Meshal Ansari, Elisabeth Graf, Tim-Matthias Strom, Monica Nagendran, Tushar Desai, Oliver Eickelberg, Matthias Mann, Fabian J. Theis, Herbert B. Schiller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict
Externí odkaz:
https://doaj.org/article/e8bbc178370d42f0a7884140d62b6b59
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Single-cell RNA sequencing is a powerful method to study gene expression, but noise in the data can obstruct analysis. Here the authors develop a denoising method based on a deep count autoencoder network that scales linearly with the number of cells
Externí odkaz:
https://doaj.org/article/73b3655c613540088d10c72597ba8d71
Autor:
Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis, Heide L. Ford
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI trans
Externí odkaz:
https://doaj.org/article/40cf1e9c00f54d94942b4feaef93dd57