Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lukas Karbacher"'
Autor:
Joseph R. Herdy, Larissa Traxler, Ravi K. Agarwal, Lukas Karbacher, Johannes C.M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Stem Cell
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086903782b873f3bf38da30838300c7
https://europepmc.org/articles/PMC10093780/
https://europepmc.org/articles/PMC10093780/
Autor:
Lucia, Zhou-Yang, Sophie, Eichhorner, Lukas, Karbacher, Lena, Böhnke, Larissa, Traxler, Jerome, Mertens
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2352
Progressive aging is a physiological process that represents a central risk factor for the development of several human age-associated chronic diseases, including neurodegenerative diseases. A major focus in biomedical research is the pursuit for app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4e4fc7a1bdee306a095c483fc52e71b
https://pubmed.ncbi.nlm.nih.gov/34324181
https://pubmed.ncbi.nlm.nih.gov/34324181
Autor:
Sophie Eichhorner, Lena Böhnke, Jerome Mertens, Lucia Zhou-Yang, Lukas Karbacher, Larissa Traxler
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616000
Progressive aging is a physiological process that represents a central risk factor for the development of several human age-associated chronic diseases, including neurodegenerative diseases. A major focus in biomedical research is the pursuit for app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9269f5cbaae3f5766abeca552062d6f
https://doi.org/10.1007/978-1-0716-1601-7_6
https://doi.org/10.1007/978-1-0716-1601-7_6
Publikováno v:
Cell Stem Cell
Cell fate conversion generally requires reprogramming effectors to both introduce fate programs of the target cell type and erase the identity of starting cell population. Here, we reveal insights into the activity of microRNAs, miR-9/9* and miR-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceca4fc68d8fdee5a16e2e41e8ebd8c1
https://doi.org/10.1016/j.stem.2020.12.007
https://doi.org/10.1016/j.stem.2020.12.007
Autor:
Shauna H. Yuan, Johannes C. M. Schlachetzki, Fred H. Gage, Dylan A. Reid, Apuã C. M. Paquola, Raffaella Lucciola, Shani Stern, Attila Szücs, Larissa Traxler, Steve Horvath, Lena Böhnke, Douglas Galasko, Simon T. Schafer, Frank Edenhofer, Christopher K. Glass, Dina Zangwill, Lukas Karbacher, Jerome Mertens, Diana P. Fernandes, Lucia Zhou-Yang, Lawrence S.B. Goldstein, Manching Ku, Hyungjun Lee, Joseph R. Herdy, Ravi K. Agarwal
Publikováno v:
Cell Stem Cell
Summary Sporadic Alzheimer’s disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee680604bac20b52230ab834cd93afc
https://doi.org/10.1016/j.stem.2021.04.004
https://doi.org/10.1016/j.stem.2021.04.004