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Akademický článek

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Autor: Miriam Rehberger, Jonas A. Schäfer, Anna-Maria Krampitz, Anne Catherine Bretz, Lukas Jost, Torsten Haferlach, Thorsten Stiewe, Andreas Neubauer

Publikováno v: HemaSphere, Vol 6, Iss 5, p e0708 (2022)

Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets u

Externí odkaz: https://doaj.org/article/95cf8d0aa0d8401b997723f0a909fa4e

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The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Autor: Miriam Rehberger, Jonas A. Schäfer, Anna-Maria Krampitz, Anne Catherine Bretz, Lukas Jost, Torsten Haferlach, Thorsten Stiewe, Andreas Neubauer

Publikováno v: HemaSphere. 6(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88992672695cca8cc4c8fce456dc6b86
https://pubmed.ncbi.nlm.nih.gov/35519003

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Bacterial Cellulose Shifts Transcriptome and Proteome of Cultured Endothelial Cells Towards Native Differentiation

Autor: Caroline Arnold, Svenja Petzoldt, Lukas Jost, Nicole Kiessling-Wolf, Gerhard Feil, Hannes Hahne, Andreas F. Mack, Ender Serbest, Thomas Korff, Chen Meng, Isabel Hartmann, Julia Schulte, Dominic Helm, Bernhard Kuster, Ralf Horres, Jochen Boxleitner

Publikováno v: Molecular & Cellular Proteomics. 16:1563-1577

Preserving the native phenotype of primary cells in vitro is a complex challenge. Recently, hydrogel-based cellular matrices have evolved as alternatives to conventional cell culture techniques. We developed a bacterial cellulose-based aqueous gel-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4579d9c2fe7ad1f68b700926e0f8383
https://doi.org/10.1074/mcp.ra117.000001

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Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study

Autor: Serena Mancarella, Francesco Dituri, Rahul Agarwal, Peter Winter, Y. Cao, Klaus Hoffmeier, Ruth Jüngling, Lukas Jost, Björn Rotter, Alejandro Rodriguez Meisel, Nicolas Krezdorn, Gianluigi Giannelli

Publikováno v: Cell Death & Disease

The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257319ec281b734207e1d2572e0732d9
https://pubmed.ncbi.nlm.nih.gov/28594404

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