Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Lukas J. Neukomm"'
Autor:
Áron Szabó, Virág Vincze, Aishwarya Sanjay Chhatre, András Jipa, Sarolta Bognár, Katalin Eszter Varga, Poulami Banik, Adél Harmatos-Ürmösi, Lukas J. Neukomm, Gábor Juhász
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Glial engulfment of neuron-derived debris after trauma, during development, and in neurodegenerative diseases supports nervous system functions. However, mechanisms governing the efficiency of debris degradation in glia have remained largely
Externí odkaz:
https://doaj.org/article/5d460e7087d74b4d9aa634afe10666ea
Autor:
Shih-Te Hung, Arnau Llobet Rosell, Daphne Jurriens, Marijn Siemons, Oleg Soloviev, Lukas C. Kapitein, Kristin Grußmayer, Lukas J. Neukomm, Michel Verhaegen, Carlas Smith
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Single-molecule localization microscopy (SMLM) enables the high-resolution visualization of organelle structures and the precise localization of individual proteins. However, the expected resolution is not achieved in tissue as the imaging conditions
Externí odkaz:
https://doaj.org/article/917f594ec7cd4c12b8702257d6f1d6ab
Autor:
Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan, Marc R. Freeman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading t
Externí odkaz:
https://doaj.org/article/a0803d1cf18d4b59932815bc571bcf90
Autor:
Arnau Llobet Rosell, Lukas J. Neukomm
Publikováno v:
Open Biology, Vol 9, Iss 8 (2019)
Axon loss is a shared feature of nervous systems being challenged in neurological disease, by chemotherapy or mechanical force. Axons take up the vast majority of the neuronal volume, thus numerous axonal intrinsic and glial extrinsic support mechani
Externí odkaz:
https://doaj.org/article/4d768c7fc8164f53a76f6d0a1b8e7ad9
Autor:
Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Massimiliano Gasparrini, Lucia Cialabrini, Nadia Raffaelli, Carlo Angeletti, Giuseppe Orsomando, Michael P. Coleman, Andrea Loreto, Lukas J. Neukomm
Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035e112f2638bfdbf2d825d1299e2901
https://doi.org/10.1101/2022.01.30.478002
https://doi.org/10.1101/2022.01.30.478002
Autor:
Kelsey A. Herrmann, Yizhou Liu, Arnau Llobet-Rosell, Colleen N. McLaughlin, Lukas J. Neukomm, Jaeda C. Coutinho-Budd, Heather T. Broihier
Publikováno v:
PLoS genetics, vol. 18, no. 6, pp. e1010257
Elucidating signal transduction mechanisms of innate immune pathways is essential to defining how they elicit distinct cellular responses. Toll-like receptors (TLR) signal through their cytoplasmic TIR domains which bind other TIR domain-containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6277c409a3acd3d14d0fd105d3c38777
https://pubmed.ncbi.nlm.nih.gov/35737721
https://pubmed.ncbi.nlm.nih.gov/35737721
Publikováno v:
Current Opinion in Neurobiology. 53:162-173
Adult, circuit-integrated neurons must be maintained and supported for the life span of their host. The attenuation of either maintenance or plasticity leads to impaired circuit function and ultimately to neurodegenerative disorders. Over the last fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2484bc2c64995e2fcfa073f08a7c7d01
https://doi.org/10.1016/j.conb.2018.08.007
https://doi.org/10.1016/j.conb.2018.08.007
Publikováno v:
Journal of visualized experiments : JoVE. (157)
Axon degeneration is a shared feature in neurodegenerative disease and when nervous systems are challenged by mechanical or chemical forces. However, our understanding of the molecular mechanisms underlying axon degeneration remains limited. Injury-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9327296d590948f59ecbf9ca229879f
https://pubmed.ncbi.nlm.nih.gov/32225164
https://pubmed.ncbi.nlm.nih.gov/32225164
Publikováno v:
Journal of Visualized Experiments.
Axon degeneration is a shared feature in neurodegenerative disease and when nervous systems are challenged by mechanical or chemical forces. However, our understanding of the molecular mechanisms underlying axon degeneration remains limited. Injury-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7ac8805aafc18be9be2b5a053d347e
https://doi.org/10.3791/60865
https://doi.org/10.3791/60865
Autor:
Lukas J. Neukomm, Marc R. Freeman, Kevin P. Kenna, Romina Barria, Jonathan E. Farley, John Landers, Thomas C. Burdett
Publikováno v:
Proceedings of the National Academy of Sciences. 115:1358-1363
Genetic studies of Wallerian degeneration have led to the identification of signaling molecules (e.g., dSarm/Sarm1, Axundead, and Highwire) that function locally in axons to drive degeneration. Here we identify a role for the Drosophila C2H2 zinc fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1f97e6842945a6b1e137f7ee3f4a66
https://doi.org/10.1073/pnas.1715837115
https://doi.org/10.1073/pnas.1715837115