Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Lukas J. A. C. Hawinkels"'
Autor:
Sarah K. Hakuno, Stefanus G. T. Janson, Marjolijn D. Trietsch, Manon de Graaf, Eveline de Jonge-Muller, Stijn Crobach, Tom J. Harryvan, Jurjen J. Boonstra, Winand N. M. Dinjens, Marije Slingerland, Lukas J. A. C. Hawinkels
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Despite the fact that the role of endoglin on endothelial cells has been extensively described, its expression and biological role on (epithelial) cancer cells is still debatable. Especially its function on squamous cell carcinoma (SCC) cells is larg
Externí odkaz:
https://doaj.org/article/05416853dd5b46b9bc43f9f08ab20a32
Autor:
Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted. Drug-drug-interaction
Externí odkaz:
https://doaj.org/article/dfd4b7aa0cba4a3db6f51c0bbc61c879
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
Autor:
Jonathan H. M. van der Meer, Ruben J. de Boer, Bartolomeus J. Meijer, Wouter L. Smit, Jacqueline L. M. Vermeulen, Sander Meisner, Manon van Roest, Pim J. Koelink, Evelien Dekker, Theodorus B. M. Hakvoort, Jan Koster, Lukas J. A. C. Hawinkels, Jarom Heijmans, Eduard A. Struijs, Marja A. Boermeester, Gijs R. van den Brink, Vanesa Muncan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Abstract The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS
Externí odkaz:
https://doaj.org/article/71fe891b64fe490ab76705ba74a38453
Autor:
Zhou Zhou, Leonie G. Plug, Thiago A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. Barnhoorn, Lukas J. A. C. Hawinkels
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the intestinal tract with currently not well-understood pathogenesis. In addition to the involvement of immune cells, increasing studies show an important role for fibroblasts in
Externí odkaz:
https://doaj.org/article/c20108b6498e4140b296ad82f27c4549
Autor:
Letizia Astrologo, Eugenio Zoni, Sofia Karkampouna, Peter C. Gray, Irena Klima, Joël Grosjean, Marie J. Goumans, Lukas J. A. C. Hawinkels, Gabri van der Pluijm, Martin Spahn, George N. Thalmann, Peter ten Dijke, Marianna Kruithof-de Julio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 5 (2017)
Prostate cancer is the second most common cancer in men and lethality is normally associated with the consequences of metastasis rather than the primary tumor. Therefore, targeting the molecular pathways that underlie dissemination of primary tumor c
Externí odkaz:
https://doaj.org/article/e90b386966e644e587ad9e9540d0b6f2
Autor:
Tom J. Harryvan, Matteo Golo, Nicole Dam, Mark J. A. Schoonderwoerd, Elham Aida Farshadi, Marten Hornsveld, Rob C. Hoeben, Lukas J. A. C. Hawinkels, Vera Kemp
Publikováno v:
Cancer Gene Therapy, 29(12), 1918-1929. Nature Publishing Group
Cancer Gene Therapy, 29, 1918-1929. SPRINGERNATURE
Cancer Gene Therapy, 29, 1918-1929. SPRINGERNATURE
Gastrointestinal (GI) cancers are characterized by extensive tumor stroma that both promotes tumor progression and acts as a physical barrier for adjacent tumor cells, limiting the effect of current treatment modalities. Oncolytic virotherapy is curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f71ebf43162eceb6a67ec90cfd70b67
http://www.scopus.com/inward/record.url?scp=85134475534&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85134475534&partnerID=8YFLogxK
Autor:
Sumit Kumar, Mark J A Schoonderwoerd, Jessie S Kroonen, Ilona J de Graaf, Marjolein Sluijter, Dina Ruano, Román González-Prieto, Matty Verlaan-de Vries, Jasper Rip, Ramon Arens, Noel F C C de Miranda, Lukas J A C Hawinkels, Thorbald van Hall, Alfred C O Vertegaal
Publikováno v:
Gut
Gut. BMJ PUBLISHING GROUP
Gut. BMJ PUBLISHING GROUP
ObjectivePancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density desmoplastic stroma, a distinctive immunosuppressive microenvironment and is profoundly resistant to all forms of chemotherapy and immunotherapy, leading to a 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8668b142ad3d0b696711f551784bd9
https://doi.org/10.1136/gutjnl-2021-324834
https://doi.org/10.1136/gutjnl-2021-324834
Autor:
Floris A. Vuijk, Fleur Kleiburg, Wyanne A. Noortman, Linda Heijmen, Shirin Feshtali Shahbazi, Floris H. P. van Velden, Victor M. Baart, Shadhvi S. Bhairosingh, Bert D. Windhorst, Lukas J. A. C. Hawinkels, Petra Dibbets-Schneider, Neanke Bouwman, Stijn A. L. P. Crobach, Arantza Fariña-Sarasqueta, Andreas W. K. S. Marinelli, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg, Frits Smit, Alexander L. Vahrmeijer, Lioe-Fee de Geus-Oei, Denise E. Hilling, Marije Slingerland
Publikováno v:
Vuijk, F A, Kleiburg, F, Noortman, W A, Heijmen, L, Feshtali Shahbazi, S, van Velden, F H P, Baart, V M, Bhairosingh, S S, Windhorst, B D, Hawinkels, L J A C, Dibbets-Schneider, P, Bouwman, N, Crobach, S A L P, Fariña-Sarasqueta, A, Marinelli, A W K S, Oprea-Lager, D E, Swijnenburg, R-J, Smit, F, Vahrmeijer, A L, de Geus-Oei, L-F, Hilling, D E & Slingerland, M 2022, ' Prostate-Specific Membrane Antigen Targeted Pet/CT Imaging in Patients with Colon, Gastric and Pancreatic Cancer ', Cancers, vol. 14, no. 24, 6209 . https://doi.org/10.3390/cancers14246209
Cancers, 14(24). MDPI
Cancers, 14(24):6209. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 24; Pages: 6209
Cancers, 14(24). MDPI
Cancers, 14(24):6209. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 24; Pages: 6209
Simple Summary Prostate-specific membrane antigen (PSMA)-targeted PET/CT imaging is increasingly being used for (re)staging in prostate cancer. Although PSMA suggests specificity to prostate cancer, previous preclinical studies and case reports have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b3fca02a447ba85fca951bea4adba1
http://www.scopus.com/inward/record.url?scp=85144973444&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85144973444&partnerID=8YFLogxK
Autor:
Manon E. Wildenberg, Liudmila L. Kodach, Gwenny M. Fuhler, Lukas J. A. C. Hawinkels, Jarom Heijmans, Maikel P. Peppelenbosch, Rutger J. Jacobs, Philip W. Voorneveld, Sarah Ouahoud, James C. H. Hardwick, Sander H. Diks
Publikováno v:
Br J Cancer
British Journal of Cancer, 124, 1978-1987. SPRINGERNATURE
British Journal of Cancer, 124(12), 1978-1987. Nature Publishing Group
British journal of cancer, 124(12), 1978-1987. Nature Publishing Group
British Journal of Cancer, 124, 1978-1987. SPRINGERNATURE
British Journal of Cancer, 124(12), 1978-1987. Nature Publishing Group
British journal of cancer, 124(12), 1978-1987. Nature Publishing Group
Background Epidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We have shown that statins act on CRC through bone morphogenetic protein (BMP) signalling, but the exact c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bf1cd6c01d3d9af58a26f586ee6726
http://www.scopus.com/inward/record.url?scp=85103082103&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85103082103&partnerID=8YFLogxK
Publikováno v:
International Journal of Molecular Sciences. 24:8707
The lack of response to therapy in pancreatic ductal adenocarcinoma (PDAC) patients has contributed to PDAC having one of the lowest survival rates of all cancer types. The poor survival of PDAC patients urges the exploration of novel treatment strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5801ebaffaceaf97aed1c1deec675d
https://doi.org/10.3390/ijms24108707
https://doi.org/10.3390/ijms24108707