Hypercapnia and lung function parameters in chronic obstructive pulmonary disease

Autor: Lukas Gernhold, Claus Neurohr, Konstantinos Tsitouras, Nina Lutz, Selina Briese, Alessandro Ghiani

Publikováno v: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-9 (2024)

Abstract Background In advanced chronic obstructive pulmonary disease (COPD), hypercapnia may occur due to severe bronchial obstruction with lung hyperinflation. Non-invasive ventilation (NIV) provides the standard of care intended to achieve physiol

Externí odkaz: https://doaj.org/article/98ef6d5ac8ff40b6a058d728bde5ea6b

Deep learning–based molecular morphometrics for kidney biopsies

Autor: Marina Zimmermann, Martin Klaus, Milagros N. Wong, Ann-Katrin Thebille, Lukas Gernhold, Christoph Kuppe, Maurice Halder, Jennifer Kranz, Nicola Wanner, Fabian Braun, Sonia Wulf, Thorsten Wiech, Ulf Panzer, Christian F. Krebs, Elion Hoxha, Rafael Kramann, Tobias B. Huber, Stefan Bonn, Victor G. Puelles

Publikováno v: JCI Insight, Vol 6, Iss 7 (2021)

Morphologic examination of tissue biopsies is essential for histopathological diagnosis. However, accurate and scalable cellular quantification in human samples remains challenging. Here, we present a deep learning–based approach for antigen-specif

Externí odkaz: https://doaj.org/article/3c08e835153e4f5397578a86dbdc44f5

Decoding myofibroblast origins in human kidney fibrosis

Autor: Nazanin Kabgani, Eric Bindels, Christoph Kuppe, Remco Hoogenboezem, Sylvia Menzel, Mahmoud M. Ibrahim, Maurice Halder, Jürgen Floege, Lukas Gernhold, Rafael Kramann, James R Smith, Julio Saez-Rodriguez, Nadine Kaesler, Victor G. Puelles, Katharina C Reimer, Neil C. Henderson, Xiaoting Zhang, Susanne Ziegler, Martin Klaus, Jennifer Kranz, Javier Perales-Patón, Rebekka K. Schneider, Peter Boor, Jitske Jansen, Yaoxian Xu, John R. Wilson-Kanamori, Tobias B. Huber, Ross Dobie, Joachim Steffens

Publikováno v: Nature, 589(7841), 281-286. Nature Publishing Group
Nature
Kuppe, C, Ibrahim, M M, Kranz, J, Zhang, X, Ziegler, S, Perales-patón, J, Jansen, J, Reimer, K C, Smith, J R, Dobie, R, Wilson-Kanamori, J R, Halder, M, Xu, Y, Kabgani, N, Kaesler, N, Klaus, M, Gernhold, L, Puelles, V G, Huber, T B, Boor, P, Menzel, S, Hoogenboezem, R M, Bindels, E M J, Steffens, J, Floege, J, Schneider, R K, Saez-rodriguez, J, Henderson, N C & Kramann, R 2021, ' Decoding myofibroblast origins in human kidney fibrosis ', Nature, vol. 589, no. 7841, pp. 281–286 . https://doi.org/10.1038/s41586-020-2941-1

Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist1–3. The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc64fb1a2170bff37bdf7554d738080
http://www.scopus.com/inward/record.url?scp=85095803958&partnerID=8YFLogxK

Deep Learning-Based Bias Transfer for Overcoming Laboratory Differences of Microscopic Images

Autor: Guido Sauter, Marina Zimmermann, Esther Dietrich, Christoph Kuppe, Victor G. Puelles, Ann-Katrin Thebille, Stefan Bonn, Rafael Kramann, Maximilian Lennartz, Lukas Gernhold, Martin Klaus, Tobias B. Huber

Publikováno v: Medical Image Understanding and Analysis ISBN: 9783030804312
MIUA

The automated analysis of medical images is currently limited by technical and biological noise and bias. The same source tissue can be represented by vastly different images if the image acquisition or processing protocols vary. For an image analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64999ac46314e247538bd0f3fac113d2
https://doi.org/10.1007/978-3-030-80432-9_25

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Autor: Tillmann Bork, Tobias B. Huber, Leon Tribolet, Fabian Braun, Rafael Kramann, Yu Bo Yang Sun, Wendy E. Hoy, Gerhard Müller-Newen, Peter G. Kerr, Christoph Kuppe, Maja T. Lindenmeyer, Nicola Wanner, Thorsten Wiech, Luc Furic, Sharon D. Ricardo, Milagros N. Wong, Clemens D. Cohen, Victor G. Puelles, Lukas Gernhold, Marcus J. Moeller, Michelle M Kett, David J. Nikolic-Paterson, Jinhua Li, Fermin Person, Markus W. Scheppach, James W. van der Wolde, Turgay Saritas, Kate M. Denton, Claudia R.C. van Roeyen, Richard J. Rebello, Michael D Hughson, John F. Bertram, Luise A. Cullen-McEwen

Publikováno v: JCI Insight

The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of rapamycin–mediated (mTOR-mediated) podocyte hypertrophy is recognized as an important si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7074ae1638c3f88833b56cbd7e4c45