Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Lukas Flatz"'
Autor:
Nathalie A. Lengacher, Julianna J. Tomlinson, Ann-Kristin Jochum, Jonas Franz, Omar Hasan Ali, Lukas Flatz, Wolfram Jochum, Josef Penninger, aSCENT-PD Investigators, Christine Stadelmann, John M. Woulfe, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract The majority of patients with Parkinson disease (PD) experience a loss in their sense of smell and accumulate insoluble α-synuclein aggregates in their olfactory bulbs (OB). Subjects affected by a SARS-CoV-2-linked illness (COVID-19) also f
Externí odkaz:
https://doaj.org/article/55e9314822274d27aa985e4800b41313
Autor:
Lisa Wiens, Gerd Grözinger, Helmut Dittmann, Karolin Thiel, Ulrike Leiter, Teresa Amaral, Lena Nanz, Lukas Flatz, Andrea Forschner
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Uveal melanoma is the most common malignant tumor of the eye in adults. About half of the patients develop distant metastases, most commonly liver metastases (>90%). These are associated with poorer overall survival compared to patients w
Externí odkaz:
https://doaj.org/article/b78e3bcdd36e47719be5e1d9b1f76552
Autor:
Francisco Meraz-Torres, Heike Niessner, Sarah Plöger, Simon Riel, Barbara Schörg, Nicolas Casadei, Manfred Kneilling, Martin Schaller, Lukas Flatz, Boris Macek, Thomas Eigentler, Olaf Rieß, Claus Garbe, Teresa Amaral, Tobias Sinnberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus,
Externí odkaz:
https://doaj.org/article/35307e889f494a0d91d148dbfa645149
Autor:
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L
Externí odkaz:
https://doaj.org/article/b3fa661fa2c8409a83b991ccda94efe7
Autor:
Daniela Lenders, Irina Bonzheim, Matthias Hahn, Maximilian Gassenmaier, Valentin Aebischer, Andrea Forschner, Max Matthias Lenders, Lukas Flatz, Stephan Forchhammer
Publikováno v:
Diagnostics, Vol 14, Iss 15, p 1644 (2024)
Background: Next-generation sequencing (NGS) is the most commonly used method for determining BRAF mutational status in patients with advanced melanoma. Automated PCR-based methods, such as the IdyllaTM system, are increasingly used for mutation diag
Externí odkaz:
https://doaj.org/article/5df4d4ba72344af2a6d94052d7443e6f
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionCombined immune checkpoint inhibition (ICI) with ipilimumab and nivolumab is a widely used treatment regimen for metastatic melanoma with non-resectable metastases. Nevertheless, the standard dose of ipilimumab 3 mg/kg bw and nivolumab 1
Externí odkaz:
https://doaj.org/article/ceb67aa294dc4f9797190022c91f9626
Autor:
Eftychia Chatziioannou, Jana Roßner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Röcken, Teresa Amaral, Tobias Sinnberg
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104644- (2023)
Summary: Background: Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) and investigate its pro
Externí odkaz:
https://doaj.org/article/35c191c0b266487cb0126f25360675a8
Autor:
Selina Reiter, Christopher Schroeder, Julian Broche, Tobias Sinnberg, Irina Bonzheim, Daniela Süsskind, Lukas Flatz, Andrea Forschner
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Metastatic uveal melanoma (UM) is a rare form of melanoma differing from cutaneous melanoma by etiology, prognosis, driver mutations, pattern of metastases and poor response rate to immune checkpoint inhibitors (ICI). Recently, a bispecific gp100 pep
Externí odkaz:
https://doaj.org/article/a89964a882e945548b25b9e0561b8872
Autor:
Lipin Loo, Matthew A Waller, Cesar L Moreno, Alexander J Cole, Alberto Ospina Stella, Oltin-Tiberiu Pop, Ann-Kristin Jochum, Omar Hasan Ali, Christopher E Denes, Zina Hamoudi, Felicity Chung, Anupriya Aggarwal, Jason K K Low, Karishma Patel, Rezwan Siddiquee, Taeyoung Kang, Suresh Mathivanan, Joel P Mackay, Wolfram Jochum, Lukas Flatz, Daniel Hesselson, Stuart Turville, G Gregory Neely
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001967 (2023)
Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-gen
Externí odkaz:
https://doaj.org/article/a8987683bf0d45a6a15d82980b6d7c2c
Autor:
Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig, Lukas Flatz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cel
Externí odkaz:
https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a7987