Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lukas Farbiak"'
Autor:
Xueliang Yu, Shuai Liu, Qiang Cheng, Sang M. Lee, Tuo Wei, Di Zhang, Lukas Farbiak, Lindsay T. Johnson, Xu Wang, Daniel John Siegwart
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1914 (2021)
Messenger RNA (mRNA) has generated great attention due to its broad potential therapeutic applications, including vaccines, protein replacement therapy, and immunotherapy. Compared to other nucleic acids (e.g., siRNA and pDNA), there are more opportu
Externí odkaz:
https://doaj.org/article/d4c84e7de6404a5fad7c36abe82adb46
Autor:
Di Zhang, Guoxun Wang, Xueliang Yu, Tuo Wei, Lukas Farbiak, Lindsay T. Johnson, Alan Mark Taylor, Jiazhu Xu, Yi Hong, Hao Zhu, Daniel J. Siegwart
Publikováno v:
Nature Nanotechnology. 17:777-787
Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours for efficient cancer therapy remains challenging. Here we targeted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7984c272628964c3565eaa2b77861507
https://doi.org/10.1038/s41565-022-01122-3
https://doi.org/10.1038/s41565-022-01122-3
Autor:
Norbert Pardi, Daria Strelkova, Jason B. Miller, Mariah L. Arral, Khalid A. Hajj, Kathryn A. Whitehead, Namit Chaudhary, Daniel J. Siegwart, Drew Weissman, Mohamad-Gabriel Alameh, Jilian R. Melamed, Lukas Farbiak
Publikováno v:
J Control Release
Therapeutic mRNA has the potential to revolutionize the treatment of myriad diseases and, in 2020, facilitated the most rapid vaccine development in history. Among the substantial advances in mRNA technology made in recent years, the incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c434ce4b0aa634f63edc9228d663653
https://doi.org/10.1016/j.jconrel.2021.11.022
https://doi.org/10.1016/j.jconrel.2021.11.022
Autor:
Osamah Mian, Lindsay T. Johnson, Erick D. Guerrero, Xu Wang, Martha Marquez Ramirez, Ester Alvarez Benedicto, Lukas Farbiak, Daniel J. Siegwart
Publikováno v:
Biomater Sci
Lipid nanoparticles (LNPs) have been established as an essential platform for nucleic acid delivery. Efforts have led to the development of vaccines that protect against SARS-CoV-2 infection using LNPs to deliver messenger RNA (mRNA) coding for the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e3a97602501adcfeb7a4ad274fe457
https://doi.org/10.1039/d1bm01454d
https://doi.org/10.1039/d1bm01454d
Autor:
Lindsay T, Johnson, Di, Zhang, Kejin, Zhou, Sang M, Lee, Shuai, Liu, Sean A, Dilliard, Lukas, Farbiak, Sumanta, Chatterjee, Yu-Hsuan, Lin, Daniel J, Siegwart
Publikováno v:
Molecular pharmaceutics. 19(11)
Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly placed on organ level delivery, which can mask cellular level effects consequential to therapeutic applications. Here, we studied a pair of LNPs with similar p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b48ab3e1b2ad785f6e56a182a7f37fdc
https://pubmed.ncbi.nlm.nih.gov/36154076
https://pubmed.ncbi.nlm.nih.gov/36154076
Autor:
Shuai Liu, Lindsay T. Johnson, Xueliang Yu, Daniel J. Siegwart, Tuo Wei, Lukas Farbiak, Qiang Cheng
Publikováno v:
Nature materials
Endosomal escape remains a fundamental barrier hindering the advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that comprise biological membranes, we report the combinatorial synthesis of multi-tailed ionizable p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d82046736e41c23518316bd66acf574
http://europepmc.org/articles/PMC8188687
http://europepmc.org/articles/PMC8188687
Autor:
Lindsay T. Johnson, Qiang Cheng, Daniel J. Siegwart, Tuo Wei, Sean A. Dilliard, Lukas Farbiak
Publikováno v:
Nature nanotechnology
CRISPR/Cas gene editing and messenger RNA (mRNA)-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfa37f0cf5d8e86b6f5d8a7ada8b636
http://europepmc.org/articles/PMC7735425
http://europepmc.org/articles/PMC7735425
Autor:
Qiang, Cheng, Tuo, Wei, Lukas, Farbiak, Lindsay T, Johnson, Sean A, Dilliard, Daniel J, Siegwart
Publikováno v:
Nature nanotechnology. 15(4)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a5b7f0e2cc63aaece6d8b4d75c41d63
https://pubmed.ncbi.nlm.nih.gov/32251384
https://pubmed.ncbi.nlm.nih.gov/32251384
Autor:
Sang M. Lee, Lindsay T. Johnson, Daniel J. Siegwart, Tuo Wei, Lukas Farbiak, Ester Álvarez-Benedicto, Qiang Cheng
Publikováno v:
Adv Mater
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein gene editing is poised to transform the treatment of genetic diseases. However, limited progress has been made toward precise editing of DNA via homolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705ec2e46644a53723766ea2ed775833
https://doi.org/10.1002/adma.202006619
https://doi.org/10.1002/adma.202006619
Autor:
Shuyuan Zhang, Kejin Zhou, Daniel J. Siegwart, Yonglong Wei, Lukas Farbiak, Yuemeng Jia, Hao Zhu, Tuo Wei, Qiang Cheng
Publikováno v:
Advanced Materials. 30:1805308
mRNA-mediated protein replacement represents a promising concept for the treatment of liver disorders. Children born with fumarylacetoacetate hydrolase (FAH) mutations suffer from Hepatorenal Tyrosinemia Type 1 (HT-1) resulting in renal dysfunction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481611e09b4426bea051c480ba326a3f
https://doi.org/10.1002/adma.201805308
https://doi.org/10.1002/adma.201805308