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Akademický článek

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

Autor: Holger H H Erb, Julia Bodenbender, Florian Handle, Tamara Diehl, Lukas Donix, Igor Tsaur, Martin Gleave, Axel Haferkamp, Johannes Huber, Susanne Fuessel, Eva Juengel, Zoran Culig, Christian Thomas

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237248 (2020)

Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of trans

Externí odkaz: https://doaj.org/article/4e67266c59d74563ae1dc628b1acd121

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Akademický článek

PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target.

Autor: Holger Hans Hermann Erb, Marlies Ebert, Ronja Kuhn, Lukas Donix, Axel Haferkamp, Robert Ian Seed, Eva Jüngel

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0224085 (2019)

Urothelial cancer (UC) is one of the most common cancers in Europe and is also one of the costliest to treat. When first line therapies show initial success, around 50% of cancers relapse and proceed to metastasis. In this study we assessed the Prote

Externí odkaz: https://doaj.org/article/2ec0d4c141d2439b9b7da7a4a4593d97

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Comprehensive Evaluation of Multiple Approaches Targeting ABCB1 to Resensitize Docetaxel-Resistant Prostate Cancer Cell Lines

Autor: Dinah Linke, Lukas Donix, Claudia Peitzsch, Holger H. H. Erb, Anna Dubrovska, Manuel Pfeifer, Christian Thomas, Susanne Fuessel, Kati Erdmann

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 666
International Journal of Molecular Sciences 24(2023)1, 666

Docetaxel (DTX) is a mainstay in the treatment of metastatic prostate cancer. Failure of DTX therapy is often associated with multidrug resistance caused by overexpression of efflux membrane transporters of the ABC family such as the glycoprotein ABC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c25589c42c037fa4303a0bf5fc7c5aa

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Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines

Autor: Lukas Donix, Holger H. H. Erb, Claudia Peitzsch, Anna Dubrovska, Manuel Pfeifer, Christian Thomas, Susanne Fuessel, Kati Erdmann

Publikováno v: Journal of Cancer Research and Clinical Oncology 148(2022), 1313-1324

Purpose Platinum chemotherapy can be considered to treat metastatic castration-resistant prostate cancer (mCRPC) with features of neuroendocrine differentiation. However, platinum compounds are generally only applied after the failure of multiple pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0fc868737773c9914a965d807ce905
https://www.hzdr.de/publications/Publ-34168-1

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Author Correction: Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions

Autor: Joanna M. Wasielewska, Gerd Kempermann, Alex M. Sykes, Lisa Grönnert, Tara L. Walker, Ruslan Rust, Axel Roers, Nicole Rund, Lukas Donix, Anja Hoppe

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific reports 10(1), 19816 (2020). doi:10.1038/s41598-020-76589-y

There is growing evidence that both peripheral and resident immune cells play an important part in regulating adult neural stem cell proliferation and neurogenesis, although the contribution of the various immune cell types is still unclear. Mast cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030ea4d9f8dc3e0772e996b02c1b641b
http://europepmc.org/articles/PMC7653037

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Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions

Autor: Axel Roers, Joanna M. Wasielewska, Lukas Donix, Tara L. Walker, Nicole Rund, Ruslan Rust, Lisa Grönnert, Gerd Kempermann, Alex M. Sykes, Anja Hoppe

Publikováno v: Scientific Reports
Scientific reports 7(1), 17859 (2017). doi:10.1038/s41598-017-18184-2
Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcdc309cddddfec5a86550530d977aa
http://europepmc.org/articles/PMC5736663

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