Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lukas Carl Heukamp"'
Autor:
Ludmilla Unrau, Jessica Endig, Diane Goltz, Paulina Sprezyna, Hanna Ulrich, Julia Hagenstein, Bernd Geers, Karina Kaftan, Lukas Carl Heukamp, Gisa Tiegs, Linda Diehl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11575 (2021)
Myeloid cells play an essential role in the maintenance of liver homeostasis, as well as the initiation and termination of innate and adaptive immune responses. In chronic hepatic inflammation, the production of transforming growth factor beta (TGF-
Externí odkaz:
https://doaj.org/article/89314a314e2c4697a1dba9997f7b133b
Autor:
Claudia Vollbrecht, Fabian Dominik Mairinger, Ulrike Koitzsch, Martin Peifer, Katharina Koenig, Lukas Carl Heukamp, Giuliano Crispatzu, Laura Wilden, Karl-Anton Kreuzer, Michael Hallek, Margarete Odenthal, Carmen Diana Herling, Reinhard Buettner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129544 (2015)
High resolution molecular studies have demonstrated that the clonal acquisition of gene mutations is an important mechanism that may promote rapid disease progression and drug resistance in chronic lymphocytic leukemia (CLL). Therefore, the early and
Externí odkaz:
https://doaj.org/article/6ad8741900c44a7e8f5cabb35c431fb3
Autor:
Carina Heydt, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Katharina König, Lukas Carl Heukamp, Hans-Ulrich Schildhaus, Margarete Odenthal, Reinhard Büttner, Sabine Merkelbach-Bruse
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104566 (2014)
Over the last years, massively parallel sequencing has rapidly evolved and has now transitioned into molecular pathology routine laboratories. It is an attractive platform for analysing multiple genes at the same time with very little input material.
Externí odkaz:
https://doaj.org/article/1b0a555199ba457291e8cd96ba50cc96
Autor:
Roopika Menon, Monique Delos, Nicky D'Haene, Sebahat Ocak, Erik Thunnissen, Birgit Weynand, Adeline Rosoux, Fabrice Duplaquet, Patrick Pauwels, Lukas Carl Heukamp
Publikováno v:
Lung cancer: journal of the International Association for the Study of Lung Cancer
Lung Cancer, 98, 118-121. Elsevier Ireland Ltd
Europe PubMed Central
Rosoux, A, Pauwels, P, Duplaquet, F, D'Haene, N, Weynand, B, Delos, M, Menon, R, Heukamp, L C, Thunnissen, E & Ocak, S 2016, ' Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma ', Lung Cancer, vol. 98, pp. 118-121 . https://doi.org/10.1016/j.lungcan.2016.06.001
Lung Cancer, 98, 118-121. Elsevier Ireland Ltd
Europe PubMed Central
Rosoux, A, Pauwels, P, Duplaquet, F, D'Haene, N, Weynand, B, Delos, M, Menon, R, Heukamp, L C, Thunnissen, E & Ocak, S 2016, ' Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma ', Lung Cancer, vol. 98, pp. 118-121 . https://doi.org/10.1016/j.lungcan.2016.06.001
We report a case of crizotinib effectiveness in a heavily pretreated patient with a metastatic NSCLC initially considered IHC-positive and FISH-negative for ALK rearrangement. After repeated analyses of tumor samples, borderline ALK FISH-positivity (
Autor:
Katharina, Biermann, Lukas Carl, Heukamp, Klaus, Steger, Hui, Zhou, Folker Ernst, Franke, Violetta, Sonnack, Ralph, Brehm, Johannes, Berg, Patrick Jan, Bastian, Stefan Cajetan, Muller, Lihua, Wang-Eckert, Reinhard, Buettner
Publikováno v:
Cancer genomicsproteomics. 4(5)
Testicular germ cell tumors (GCT) are the most frequent malignancy in young adults and arise from intratubular germ cell neoplasia undetermined (IGCNU, also referred to as carcinoma in situ, CIS). To determine the transcriptional programs involved in
Autor:
Katharina, Biermann, Lukas Carl, Heukamp, Klaus, Steger, Hui, Zhou, Folker Ernst, Franke, Ines, Guetgemann, Violetta, Sonnack, Ralph, Brehm, Johannes, Berg, Patrick Jan, Bastian, Stefan Cajetan, Müller, Lihua, Wang-Eckert, Hubert, Schorle, Reinhard, Büttner
Publikováno v:
Anticancer research. 27(5A)
There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU).Global gene expression was
Autor:
Lukas Carl, Heukamp, Detlef-Wilhelm, Schröder, Dominik, Plassmann, Jürgen, Homann, Reinhard, Büttner
Publikováno v:
Pathology, research and practice. 199(3)
Type-1 Gaucher's disease represents the most common lysosomal storage disorder. With the introduction of enzyme replacement therapy, many of the clinical manifestations can be controlled. The functional deficiency of the lysosomal beta-glucocerebrosi
Autor:
Sebastian Yves Friedrich Michels, Matthias Scheffler, Masyar Gardizi, Marc Christiaan Allardt Bos, Lucia Nogova, Katharina Koenig, Jana Fassunke, Carina Heydt, Ihle Michaela, Helen Kuenstlinger, Karin Toepelt, Frank Ueckeroth, Kerstin Albus, Monika Heidi Serke, Winfried Randerath, Walburga Engel-Riedel, Sabine Merkelbach-Bruse, Lukas Carl Heukamp, Reinhard Buettner, Juergen Wolf
Publikováno v:
Journal of Clinical Oncology. 32:1527-1527
1527 Background: Somatic mutations of the PIK3CA gene have been described in non-small cell lung cancer (NSCLC), but limited data is available on their biological relevance. This study was performe...