Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Lukas C. Kühn"'
Autor:
Afzal M Dogar, Ramona Pauchard-Batschulat, Barbara Grisoni-Neupert, Larry Richman, Alexandra Paillusson, Sylvain Pradervand, Otto Hagenbüchle, Giovanna Ambrosini, Christoph D Schmid, Philipp Bucher, Lukas C Kühn
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206823 (2018)
Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in m
Externí odkaz:
https://doaj.org/article/d43d4b9a7f234dc59c8770670f14857f
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89270 (2014)
The immune system and iron availability are intimately linked as appropriate iron supply is needed for cell proliferation, while excess iron, as observed in hemochromatosis, may reduce subsets of lymphocytes. We have tested the effects of a ferritin
Externí odkaz:
https://doaj.org/article/ba2833c096394994b75356945d848b06
Autor:
Abolfazl Zarjou, József Balla, Deepak Darshan, Eugene O. Apostolov, Anupam Agarwal, Jill W. Verlander, Reny Joseph, Lukas C. Kühn, Paolo Arosio, Amie M. Traylor, Subhashini Bolisetty
Publikováno v:
Journal of Clinical Investigation. 123:4423-4434
Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity. The purpose of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c043713ed28874519be58824e0c43c22
https://doi.org/10.1172/jci67867
https://doi.org/10.1172/jci67867
Autor:
Ramona Pauchard-Batschulat, Christoph D. Schmid, Larry Richman, Barbara Grisoni-Neupert, Otto Hagenbüchle, Philipp Bucher, Alexandra Paillusson, Afzal M. Dogar, Lukas C. Kühn, Giovanna Ambrosini, Sylvain Pradervand
Publikováno v:
PloS one, vol. 13, no. 11, pp. e0206823
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206823 (2018)
PLoS ONE, 13 (11)
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206823 (2018)
PLoS ONE, 13 (11)
Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbd5b96a862ac88106cc064ec8ea733
https://doi.org/10.1371/journal.pone.0206823
https://doi.org/10.1371/journal.pone.0206823
Publikováno v:
Hepatology. 50:852-860
Ferritin plays a central role in iron metabolism by acting both as iron storage and a detoxifying protein. We generated a ferritin H allele with loxP sites and studied the conditional ferritin H deletion in adult mice. Ten days after Mx-Cre induced d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacdc3892cbde5c682d82976bf406e11
https://doi.org/10.1002/hep.23058
https://doi.org/10.1002/hep.23058
Autor:
Lukas C. Kühn
Publikováno v:
Nutrition Reviews. 56:S11-S19
In recent years, specific post-transcriptional mechanisms in the cytoplasm of vertebrate cells have been elucidated that directly affect the stability and translation of mRNAs coding for central proteins in iron metabolism. This review shall focus pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710e5a0a6afe38de2a2f51131f7a3b6e
https://doi.org/10.1111/j.1753-4887.1998.tb01681.x
https://doi.org/10.1111/j.1753-4887.1998.tb01681.x
Autor:
Cesare Peschle, Maria Teresa Quaranta, Elvira Pelosi, Ugo Testa, Marina Petrini, Lukas C. Kühn
Note: Department of Hematology-Oncology, Istituto Superiore di Sanita, Rome, Italy. (Invited paper) Reference GR-KUHN-ARTICLE-1991-004 Record created on 2008-02-25, modified on 2017-05-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c8eba8537950dce36c52719bb99b20
https://doi.org/10.1159/000419355
https://doi.org/10.1159/000419355
Publikováno v:
FEBS Journal. 272:5217-5229
Cyclins are the essential regulatory subunits of cyclin-dependent protein kinases. They accumulate and disappear periodically at specific phases of the cell cycle. Here we investigated whether variations in cyclin mRNA levels in exponentially growing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56684d3b7180e9907f54b5a9fc76418
https://doi.org/10.1111/j.1742-4658.2005.04918.x
https://doi.org/10.1111/j.1742-4658.2005.04918.x
Autor:
Ugo Testa, Edvige Perrotti, Valentina Lulli, Lukas C. Kühn, Eliana M. Coccia, Rémy Moret, Ramona Ilari, Giovanna Marziali, Angela Battistini
Publikováno v:
Oncogene. 21:7933-7944
High expression of transferrin receptor (TfR) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis. Several studies indicate that during erythroid differentiation TfR expression is highly dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb92588466e3acf59906c9b590c443c
https://doi.org/10.1038/sj.onc.1205925
https://doi.org/10.1038/sj.onc.1205925
Autor:
François Verrey, Grégoire Rossier, Jan Loffing, Rahel Pfeiffer, Thomas Eggermann, Christian Bauch, Christian Meier, Lukas C. Kühn, Dominique Loffing-Cueni
Publikováno v:
Molecular Biology of the Cell. 10:4135-4147
Mutations of the glycoprotein rBAT cause cystinuria type I, an autosomal recessive failure of dibasic amino acid transport (b0,+type) across luminal membranes of intestine and kidney cells. Here we identify the permease-like protein b0,+AT as the cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf10f7362a934289f3380fa34e318d2
https://doi.org/10.1091/mbc.10.12.4135
https://doi.org/10.1091/mbc.10.12.4135