Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Lukas C Kapitein"'
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/c4d684977fa94216bc27d0d82600c5d9
Autor:
Fangrui Chen, Jingchao Wu, Malina K Iwanski, Daphne Jurriens, Arianna Sandron, Milena Pasolli, Gianmarco Puma, Jannes Z Kromhout, Chao Yang, Wilco Nijenhuis, Lukas C Kapitein, Florian Berger, Anna Akhmanova
Publikováno v:
eLife, Vol 11 (2022)
The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and anchors microtubules. Centrosome assembly depends on PCM binding to centri
Externí odkaz:
https://doaj.org/article/8986299997104d93a85b955cfefdb08d
Publikováno v:
eLife, Vol 11 (2022)
Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light microscopy that can be applied in both tissues and cells. In ExM, samples are embedded in a swellable polymer gel to physically expand the sample and isotro
Externí odkaz:
https://doaj.org/article/66868444eaaa4cb08abd366d8ad5018d
Publikováno v:
eLife, Vol 10 (2021)
The neuronal microtubule cytoskeleton underlies the polarization and proper functioning of neurons, amongst others by providing tracks for motor proteins that drive intracellular transport. Different subsets of neuronal microtubules, varying in compo
Externí odkaz:
https://doaj.org/article/64fa10f9e9084e89a85329a59a4528b5
Autor:
Peter Jan Hooikaas, Hugo GJ Damstra, Oane J Gros, Wilhelmina E van Riel, Maud Martin, Yesper TH Smits, Jorg van Loosdregt, Lukas C Kapitein, Florian Berger, Anna Akhmanova
Publikováno v:
eLife, Vol 9 (2020)
When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known abou
Externí odkaz:
https://doaj.org/article/214be55f9dba4de5a46f9e276769038b
Autor:
Andrea Serra-Marques, Maud Martin, Eugene A Katrukha, Ilya Grigoriev, Cathelijn AE Peeters, Qingyang Liu, Peter Jan Hooikaas, Yao Yao, Veronika Solianova, Ihor Smal, Lotte B Pedersen, Erik Meijering, Lukas C Kapitein, Anna Akhmanova
Publikováno v:
eLife, Vol 9 (2020)
Intracellular transport relies on multiple kinesins, but it is poorly understood which kinesins are present on particular cargos, what their contributions are and whether they act simultaneously on the same cargo. Here, we show that Rab6-positive sec
Externí odkaz:
https://doaj.org/article/10b150a341b6435fb225393c385d9265
Autor:
Wilhelmina E van Riel, Ankit Rai, Sarah Bianchi, Eugene A Katrukha, Qingyang Liu, Albert JR Heck, Casper C Hoogenraad, Michel O Steinmetz, Lukas C Kapitein, Anna Akhmanova
Publikováno v:
eLife, Vol 6 (2017)
Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus end
Externí odkaz:
https://doaj.org/article/6f94d5e6bfaf4dc0957d5bb79b6a6008
Autor:
Max eAdrian, Remy eKusters, Corette J Wierenga, Cornelis eStorm, Casper C Hoogenraad, Lukas C Kapitein
Publikováno v:
Frontiers in Neuroanatomy, Vol 8 (2014)
Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the central nervous system. The head of the spine is connected to the dendritic shaft by a 50-400 nm thin membrane tube, called the spine neck, which has
Externí odkaz:
https://doaj.org/article/4e2f5188605f423cbce7e02f7c460fb6
Autor:
Casper C Hoogenraad, Ioana Popa, Kensuke Futai, Emma Martinez-Sanchez, Phebe S Wulf, Thijs van Vlijmen, Bjorn R Dortland, Viola Oorschot, Roland Govers, Maria Monti, Albert J R Heck, Morgan Sheng, Judith Klumperman, Holger Rehmann, Dick Jaarsma, Lukas C Kapitein, Peter van der Sluijs
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000283 (2010)
The endosomal pathway in neuronal dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. However, the molecular mechanisms that organize specific endocytic trafficking routes are poorly understood. Here,
Externí odkaz:
https://doaj.org/article/98c2d88c5c704473b4b6e24a6964572a
Autor:
Takahiro Deguchi, Malina K. Iwanski, Eva-Maria Schentarra, Christopher Heidebrecht, Lisa Schmidt, Jennifer Heck, Tobias Weihs, Sebastian Schnorrenberg, Philipp Hoess, Sheng Liu, Veronika Chevyreva, Kyung-Min Noh, Lukas C. Kapitein, Jonas Ries
Publikováno v:
Science
Dynamic measurements of molecular machines can provide invaluable insights into their mechanism, but have been challenging in living cells. Here, we developed live-cell tracking of single fluorophores with nanometer spatial and millisecond temporal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83158acd498db94461af0944e894f3ef
https://doi.org/10.1126/science.ade2676
https://doi.org/10.1126/science.ade2676