Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Lukas C, Heukamp"'
Autor:
Balázs Jóri, Christine Vössing, Judith Pirngruber, Eva Maria Willing, Kathrin Arndt, Markus Falk, Markus Tiemann, Lukas C. Heukamp, Petra Hoffknecht
Publikováno v:
Current Oncology, Vol 30, Iss 10, Pp 8805-8814 (2023)
EGFR-mutant lung cancers develop a wide range of potential resistance alterations under therapy with the third-generation EGFR tyrosine kinase inhibitor osimertinib. MET amplification ranks among the most common acquired resistance alterations and is
Externí odkaz:
https://doaj.org/article/4e628e918b044546be96ca670e533995
Autor:
Balázs Jóri, Markus Falk, Iris Hövel, Peggy Weist, Markus Tiemann, Lukas C. Heukamp, Frank Griesinger
Publikováno v:
Current Oncology, Vol 29, Iss 9, Pp 6628-6634 (2022)
Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK)/receptor tyrosine kinase inhibitor (ROS1), demonstrated efficacy in ROS1 positive (ROS1+) non-small cell lung cancer (NSCLC), although approval is currently limited to the treatment of A
Externí odkaz:
https://doaj.org/article/01713b1bc883416682ca8dad6191d905
Autor:
Keerthika Lohanadan, Marvin Assent, Anja Linnemann, Julia Schuld, Lukas C. Heukamp, Karsten Krause, Matthias Vorgerd, Jens Reimann, Anne Schänzer, Gregor Kirfel, Dieter O. Fürst, Peter F. M. Van der Ven
Publikováno v:
Cells, Vol 13, Iss 1, p 85 (2023)
Synaptopodin-2 (SYNPO2) is a protein associated with the Z-disc in striated muscle cells. It interacts with α-actinin and filamin C, playing a role in Z-disc maintenance under stress by chaperone-assisted selective autophagy (CASA). In smooth muscle
Externí odkaz:
https://doaj.org/article/d61f3e09ff804350af78d9e5e1d5ffbd
Autor:
Eva-Maria Willing, Claudia Vollbrecht, Christine Vössing, Peggy Weist, Simon Schallenberg, Johanna M. Herbst, Stefanie Schatz, Balázs Jóri, Guillaume Bataillon, Philipp Harter, Vanda Salutari, Antonio Gonzáles Martin, Ignace Vergote, Nicoletta Colombo, Julia Roeper, Tobias Berg, Regina Berger, Bettina Kah, Trine Jakobi Noettrup, Markus Falk, Kathrin Arndt, Andreas Polten, Isabelle Ray-Coquard, Franziska Selzam, Judith Pirngruber, Stefanie Schmidt, Michael Hummel, Markus Tiemann, David Horst, Jalid Sehouli, Eric Pujade-Lauraine, Katharina Tiemann, Elena Ioana Braicu, Lukas C. Heukamp
Publikováno v:
Cancers, Vol 15, Iss 13, p 3445 (2023)
The worldwide approval of the combination maintenance therapy of olaparib and bevacizumab in advanced high-grade serous ovarian cancer requires complex molecular diagnostic assays that are sufficiently robust for the routine detection of driver mutat
Externí odkaz:
https://doaj.org/article/628b6ba5d10e423992d704d588ad94ad
Autor:
Florian Heitz, Sotirios Lakis, Philipp Harter, Sebastian Heikaus, Jalid Sehouli, Jatin Talwar, Roopika Menon, Beyhan Ataseven, Miriam Bertrand, Stephanie Schneider, Erika Mariotti, Mareike Bommert, Judith N Müller, Sonia Prader, Frauke Leenders, Alexandra Hengsbach, Christian Gloeckner, Elena Ioana Braicu, Lukas C Heukamp, Andreas du Bois, Johannes M Heuckmann
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262770 (2022)
BackgroundThe present prospective study aimed at determining the impact of cell-free tumor DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden in patients with advanced high-grade serous epithelial ovarian cancer (EO
Externí odkaz:
https://doaj.org/article/e2bb896377e24b0ba18e2a7ddeeda5de
Autor:
Bettina Tosetti, Beate Ward, Daniela Grumme, Marc Herb, Michael Schramm, Olaf Utermöhlen, Lukas C. Heukamp, Martin Krönke, Oleg Krut
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although the crucial role of professional phagocytes for the clearance of S. aureus infections is well-established, several studies indicate an adverse role of leukocytes in the dissemination of S. aureus during infection. Since only little is known
Externí odkaz:
https://doaj.org/article/920071676b7d46e2a63c059c36ba6464
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minima
Externí odkaz:
https://doaj.org/article/4e258299049a4d389e43ad67ce587e37
Autor:
Caroline Volz, Sara Breid, Carolin Selenz, Alina Zaplatina, Kristina Golfmann, Lydia Meder, Felix Dietlein, Sven Borchmann, Sampurna Chatterjee, Maike Siobal, Jakob Schöttle, Alexandra Florin, Mirjam Koker, Marieke Nill, Luka Ozretić, Niklas Uhlenbrock, Steven Smith, Reinhard Büttner, Hui Miao, Bingcheng Wang, H. Christian Reinhardt, Daniel Rauh, Michael Hallek, Amparo Acker-Palmer, Lukas C. Heukamp, Roland T. Ullrich
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF)-VEGFR2 signaling has shown limited efficacy in lung cancer patients. Here, we demonstrate that inhibition of VEGFR2 in tumor cells, expressed in ∼20% of non-squa
Externí odkaz:
https://doaj.org/article/facb3169b7084c8eb4f67f107da06c75
Autor:
Annabell Szymansky, Louisa-Marie Kruetzfeldt, Lukas C. Heukamp, Falk Hertwig, Jessica Theissen, Hedwig E. Deubzer, Eva-Maria Willing, Roopika Menon, Steffen Fuchs, Theresa Thole, Stefanie Schulte, Karin Schmelz, Annette Künkele, Peter Lang, Jörg Fuchs, Angelika Eggert, Cornelia Eckert, Matthias Fischer, Anton G. Henssen, Elias Rodriguez-Fos, Johannes H. Schulte
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 8, p 691 (2021)
For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent years, genome analysis has revealed further alterations defining risk, tumor biology, and therapeutic targ
Externí odkaz:
https://doaj.org/article/79704f85d10c468dac5d38d0c5ae4354
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 3500K, Potency of KU60648 across 94 cancer cell lines (Figure S1), comparison of KU60648-sensitivity in mutant vs. wildtype lines for 9 exemplary DNA repair-associated genes (Figure S2), MSH3 variants and Sanger sequencing of BRCA1 (Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db39079aecdda6f5c42924ff6abace2
https://doi.org/10.1158/2159-8290.22529814.v1
https://doi.org/10.1158/2159-8290.22529814.v1