Výsledky vyhledávání - "Lukas C, Heukamp"

Akademický článek

The Combined Therapy of Cabozantinib, Crizotinib, and Osimertinib in a Lung Cancer Patient with Acquired MET Amplification and Resistance Mutations

Autor: Balázs Jóri, Christine Vössing, Judith Pirngruber, Eva Maria Willing, Kathrin Arndt, Markus Falk, Markus Tiemann, Lukas C. Heukamp, Petra Hoffknecht

Publikováno v: Current Oncology, Vol 30, Iss 10, Pp 8805-8814 (2023)

EGFR-mutant lung cancers develop a wide range of potential resistance alterations under therapy with the third-generation EGFR tyrosine kinase inhibitor osimertinib. MET amplification ranks among the most common acquired resistance alterations and is

Externí odkaz: https://doaj.org/article/4e628e918b044546be96ca670e533995

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Akademický článek

Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy

Autor: Balázs Jóri, Markus Falk, Iris Hövel, Peggy Weist, Markus Tiemann, Lukas C. Heukamp, Frank Griesinger

Publikováno v: Current Oncology, Vol 29, Iss 9, Pp 6628-6634 (2022)

Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK)/receptor tyrosine kinase inhibitor (ROS1), demonstrated efficacy in ROS1 positive (ROS1+) non-small cell lung cancer (NSCLC), although approval is currently limited to the treatment of A

Externí odkaz: https://doaj.org/article/01713b1bc883416682ca8dad6191d905

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Akademický článek

Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns

Autor: Keerthika Lohanadan, Marvin Assent, Anja Linnemann, Julia Schuld, Lukas C. Heukamp, Karsten Krause, Matthias Vorgerd, Jens Reimann, Anne Schänzer, Gregor Kirfel, Dieter O. Fürst, Peter F. M. Van der Ven

Publikováno v: Cells, Vol 13, Iss 1, p 85 (2023)

Synaptopodin-2 (SYNPO2) is a protein associated with the Z-disc in striated muscle cells. It interacts with α-actinin and filamin C, playing a role in Z-disc maintenance under stress by chaperone-assisted selective autophagy (CASA). In smooth muscle

Externí odkaz: https://doaj.org/article/d61f3e09ff804350af78d9e5e1d5ffbd

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Akademický článek

Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer.

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0262770 (2022)

BackgroundThe present prospective study aimed at determining the impact of cell-free tumor DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden in patients with advanced high-grade serous epithelial ovarian cancer (EO

Externí odkaz: https://doaj.org/article/e2bb896377e24b0ba18e2a7ddeeda5de

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Akademický článek

NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection

Autor: Bettina Tosetti, Beate Ward, Daniela Grumme, Marc Herb, Michael Schramm, Olaf Utermöhlen, Lukas C. Heukamp, Martin Krönke, Oleg Krut

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Although the crucial role of professional phagocytes for the clearance of S. aureus infections is well-established, several studies indicate an adverse role of leukocytes in the dissemination of S. aureus during infection. Since only little is known

Externí odkaz: https://doaj.org/article/920071676b7d46e2a63c059c36ba6464

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Akademický článek

Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Autor: Aparna Iyer, Teodora Radonic, Lukas C. Heukamp, Erik Thunnissen, Johannes M.A. Daniels

Publikováno v: ERJ Open Research, Vol 7, Iss 1 (2021)

Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minima

Externí odkaz: https://doaj.org/article/4e258299049a4d389e43ad67ce587e37

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Akademický článek

Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

Publikováno v: Cell Reports, Vol 31, Iss 4, Pp - (2020)

Summary: Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF)-VEGFR2 signaling has shown limited efficacy in lung cancer patients. Here, we demonstrate that inhibition of VEGFR2 in tumor cells, expressed in ∼20% of non-squa

Externí odkaz: https://doaj.org/article/facb3169b7084c8eb4f67f107da06c75

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Akademický článek

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

Publikováno v: Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)

Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcin

Externí odkaz: https://doaj.org/article/65260813004b4d5e8d198b9f59d2baa6

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Supplementary Figures S1-S10 from A Functional Cancer Genomics Screen Identifies a Druggable Synthetic Lethal Interaction between MSH3 and PRKDC

Autor: H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein

PDF file 3500K, Potency of KU60648 across 94 cancer cell lines (Figure S1), comparison of KU60648-sensitivity in mutant vs. wildtype lines for 9 exemplary DNA repair-associated genes (Figure S2), MSH3 variants and Sanger sequencing of BRCA1 (Figure S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db39079aecdda6f5c42924ff6abace2
https://doi.org/10.1158/2159-8290.22529814.v1

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