Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lukas Bade"'
Publikováno v:
Actuators, Vol 13, Iss 10, p 425 (2024)
The increasing demand for innovative grippers and actuators for the automation sector encourages the development of new and innovative functional principles. Intelligent materials are particularly suitable for this purpose based on their high energy
Externí odkaz:
https://doaj.org/article/d4815f64054440a5b8bb2a01c61ebbf8
Autor:
Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse J. Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114175- (2024)
Summary: Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predic
Externí odkaz:
https://doaj.org/article/cf2194b70a344373b2d1a869bceef1a4
Autor:
Burcu Bestas, Sandra Wimberger, Dmitrii Degtev, Alexandra Madsen, Antje K. Rottner, Fredrik Karlsson, Sergey Naumenko, Megan Callahan, Julia Liz Touza, Margherita Francescatto, Carl Ivar Möller, Lukas Badertscher, Songyuan Li, Silvia Cerboni, Niklas Selfjord, Elke Ericson, Euan Gordon, Mike Firth, Krzysztof Chylinski, Amir Taheri-Ghahfarokhi, Mohammad Bohlooly-Y, Mike Snowden, Menelaos Pangalos, Barrett Nuttall, Pinar Akcakaya, Grzegorz Sienski, Marcello Maresca
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often induces undesired mutations and chromosomal rearrangements. Several strategies for mapping off-target e
Externí odkaz:
https://doaj.org/article/38a10f4c4aec4a10a368862ab670a60b
Autor:
Alena Ivanova, Lukas Badertscher, Gwen O'Driscoll, Joakim Bergman, Euan Gordon, Anders Gunnarsson, Camilla Johansson, Michael J. Munson, Cristiana Spinelli, Sara Torstensson, Liisa Vilén, Andrei Voirel, John Wiseman, Janusz Rak, Niek Dekker, Elisa Lázaro‐Ibáñez
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the repurposing of extracellular vesicles (EVs) as drug delivery vehicles are explored. Target
Externí odkaz:
https://doaj.org/article/e1d689279e454812aab0d9be5d04dcd4
Autor:
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be
Externí odkaz:
https://doaj.org/article/8d05a4aa843b419591409ca746b331db
Autor:
Lukas Badertscher, Thomas Wild, Christian Montellese, Leila T. Alexander, Lukas Bammert, Marie Sarazova, Michael Stebler, Gabor Csucs, Thomas U. Mayer, Nicola Zamboni, Ivo Zemp, Peter Horvath, Ulrike Kutay
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2879-2891 (2015)
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process. However, many aspects of ribosome synthesis are different in h
Externí odkaz:
https://doaj.org/article/7a6924e3cea44923a8113320fe4574cf
Autor:
Thomas Wild, Peter Horvath, Emanuel Wyler, Barbara Widmann, Lukas Badertscher, Ivo Zemp, Karol Kozak, Gabor Csucs, Elsebet Lund, Ulrike Kutay
Publikováno v:
PLoS Biology, Vol 8, Iss 10, p e1000522 (2010)
The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40
Externí odkaz:
https://doaj.org/article/f35353ff10fa49298dbde8fdb4e2435c