Výsledky vyhledávání - "Lukas A. Oomen"

Immunogenicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response

Autor: Lukas A. Oomen, Leo van Buren, Odo de Weers, María Eugenia Rodríguez, Jan Poolman, Germie P. J. M. van den Dobbelsteen, Michel Beurret, Peter Hoogerhout

Publikováno v: Vaccine. 16:1941-1949

The immunogenicity of two types of Streptococcus pneumoniae capsular polysaccharide-tetanus toxoid conjugates (PS6BTT and PS14TT) was evaluated in mice. Both conjugates induced high titres of high avidity type-specific anti-PS IgG, which include all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2760f6637851621266e6c05c0bef8c9d
https://doi.org/10.1016/s0264-410x(98)00129-7

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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors

Autor: Wim K. Bleeker, Matthias Peipp, Joost M. Bakker, Jan G. J. van de Winkel, Michel de Weers, Michael S. van der Veer, Kenneth C. Anderson, Paul W. H. I. Parren, Thomas Valerius, Yu-Tzu Tai, Jerry W. Slootstra, Tom Vink, Lukas A. Oomen, Tuna Mutis, Daniëlle C H Jacobs, Henk M. Lokhorst

Publikováno v: De Weers, M, Tai, Y T, Van Der Veer, M S, Bakker, J M, Vink, T, Jacobs, D C H, Oomen, L A, Peipp, M, Valerius, T, Slootstra, J W, Mutis, T, Bleeker, W K, Anderson, K C, Lokhorst, H M, Van De Winkel, J G J & Parren, P W H I 2011, ' Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors ', Journal of Immunology, vol. 186, no. 3, pp. 1840-1848 . https://doi.org/10.4049/jimmunol.1003032
Journal of Immunology, 186(3), 1840-1848. American Association of Immunologists

CD38, a type II transmembrane glycoprotein highly expressed in hematological malignancies including multiple myeloma (MM), represents a promising target for mAb-based immunotherapy. In this study, we describe the cytotoxic mechanisms of action of dar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35212ba26b9a29a8ec88dd7dd78bdff
https://research.vumc.nl/en/publications/b6b6ee97-74dc-48a1-a8fe-33f5e327772b

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Preparation of Polysaccharide-Conjugate Vaccines

Autor: Odo de Weers, Karen M. Reddin, Carla C. A. M. Peeters, Peter Hoogerhout, Michel Beurret, Patrick R. Lagerman, Jan Poolman, Lukas A. Oomen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07006c05c4701becb1b9c940f7068ce9
https://doi.org/10.1385/1-59259-399-2:153

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PolysaccharicbConjugate Vaccines

Autor: Carla C. A. M. Peeters, Michel Beurret, Jan Poolman, Lukas A. Oomen, Patrick R. Lagerman, Odo de Weers, Peter Hoogerhout

It was recognized early this century that small molecules, called haptens, can be made immunogenic after conjugation to carrier proteins (1), This principle was thereafter applied successfully to improve the rmmunogenicity of (poly)saccharides (2, 3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6f59bcbdd3522dbf75d7b0ec96daae1
https://doi.org/10.1385/0-89603-334-1:111

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Preparation of polysaccharide-conjugate vaccines

Autor: Carla C A M, Peeters, Patrick R, Lagerman, Odo, de Weers, Lukas A, Oomen, Peter, Hoogerhout, Michel, Beurret, Jan T, Poolman, Karen M, Reddin

Publikováno v: Methods in molecular medicine. 87

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c7f81b20844a21555ec43440b09c7ae
https://pubmed.ncbi.nlm.nih.gov/12958455

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Are the Enzyme Immunoassays for Antibodies to Pneumococcal Capsular Polysaccharides Serotype Specific?

Autor: Anu Soininen, Helena Käyhty, Germie P. J. M. van den Dobbelsteen, Lukas A. Oomen

The specificity of antibody binding to pneumococcal capsular polysaccharides (Pnc PSs) measured by enzyme immunoassay (EIA) was studied by inhibition of antibody binding by homologous and heterologous PSs. We found extensive cross-reactivity of antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bbc5ee4b2f91a5ac605554c173418f
https://europepmc.org/articles/PMC95896/

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Application of cystamine and N,N'-Bis(glycyl)cystamine as linkers in polysaccharide-protein conjugation

Autor: Jan Poolman, L van Buren, Michel Beurret, Peter Hoogerhout, O de Weers, Lukas A. Oomen

Publikováno v: Bioconjugate chemistry. 9(3)

Pneumococcal polysaccharide type 6B, 14, or 23F (35-70 kDa) was activated with cyanogen bromide and modified with cystamine. After reduction of the spacer, the thiol-containing (i.e. cysteamine-modified) polysaccharide obtained was added in a 5-10-fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3565ece4a2bded92b9324e122a7b1a8b
https://pubmed.ncbi.nlm.nih.gov/9576804

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Daratumumab, a Novel Potent Human Anti-CD38 Monoclonal Antibody, Induces Significant Killing of Human Multiple Myeloma Cells: Therapeutic Implication

Autor: Yu-Tzu Tai, Joost M. Bakker, Xian-Feng Li, Weihua Song, Daniëlle C H Jacobs, Sabikun Nahar, Wim K. Bleeker, Paul G. Richardson, Tom Vink, Nikhil C. Munshi, Lukas A. Oomen, Jan G. J. van de Winkel, Michel de Weers, Kenneth C. Anderson, Paul W. H. I. Parren

Publikováno v: Blood. 114:608-608

Abstract 608 CD38 is a type II transmembrane glycoprotein highly expressed in many hematological malignancies including multiple myeloma (MM), representing a promising target for monoclonal antibody (mAb)-based targeted immunotherapy. We here investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67b87fb217e4864c76f551cdce6bde1a
https://doi.org/10.1182/blood.v114.22.608.608

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