Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lukas, Sušac"'
Autor:
Alexander Domnick, Christian Winter, Lukas Sušac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The immune system monitors the health status of cells by surveilling fragments of foreign molecules from invaders presented on MHC I complexes at the cell surface. Here, the authors investigate the sequence of events of MHC I assembly and quality con
Externí odkaz:
https://doaj.org/article/269dfaffa8884380b1cc6b3634743425
Autor:
Yao He, He Song, Henry Chan, Baocheng Liu, Yaqiang Wang, Lukas Sušac, Z. Hong Zhou, Juli Feigon
Publikováno v:
Nature, vol 608, iss 7924
Nature
Nature
Telomeres are the physical ends of linear chromosomes. They are composed of short repeating sequences (such as TTGGGG in the G-strand for Tetrahymena thermophila) of double-stranded DNA with a single-strand 3'overhang of the G-strand and, in humans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b266411c25e8ca43adb66fd37170125
https://doi.org/10.1038/s41586-022-04931-7
https://doi.org/10.1038/s41586-022-04931-7
The heterotetrameric human transfer RNA (tRNA) splicing endonuclease (TSEN) catalyzes the excision of intronic sequences from precursor tRNAs (pre-tRNAs)1. Mutations in TSEN and its associated RNA kinase CLP1 are linked to the neurodegenerative disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e5b59343f657cbddb7c9d55b15a57b
https://doi.org/10.1101/2022.09.03.506465
https://doi.org/10.1101/2022.09.03.506465
Autor:
Lukas Sušac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O’Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Publikováno v:
Cell
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. To explore the structural basis of how TCR signaling is initiated when the receptor binds to peptide-loaded major histocompatibility c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdf4904f7be9ad5b6aeb68e5d3383e0
https://doi.org/10.1016/j.cell.2022.07.010
https://doi.org/10.1016/j.cell.2022.07.010
Publikováno v:
Proc Natl Acad Sci U S A
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replication. Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, what define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::786ef08e1cb22ce66930958804a577df
https://pubmed.ncbi.nlm.nih.gov/33229538
https://pubmed.ncbi.nlm.nih.gov/33229538
Autor:
Baocheng Liu, Z. Hong Zhou, Ryan Cheng, Lukas Sušac, Juli Feigon, Yao He, Christina Helmling, Yaqiang Wang
Publikováno v:
Nature
Nature, vol 593, iss 7859
Nature, vol 593, iss 7859
Telomerase is unique among the reverse transcriptases in containing a noncoding RNA (known as telomerase RNA (TER)) that includes a short template that is used for the processive synthesis of G-rich telomeric DNA repeats at the 3′ ends of most euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e049cbf185b6c272ade4c583a529735
https://pubmed.ncbi.nlm.nih.gov/33981033
https://pubmed.ncbi.nlm.nih.gov/33981033
Publikováno v:
Proceedings of the National Academy of Sciences. 115:12733-12738
The human proteome contains 826 G protein-coupled receptors (GPCR), which control a wide array of key physiological functions, making them important drug targets. GPCR functions are based on allosteric coupling from the extracellular orthosteric drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf6670fadf37565465d94e5a9cd6e1f
https://doi.org/10.1073/pnas.1813649115
https://doi.org/10.1073/pnas.1813649115
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 49
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replication. Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, what define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdb7af3c1965057ee93f2de18f60ff1
https://doi.org/10.1016/j.bpj.2020.11.1037
https://doi.org/10.1016/j.bpj.2020.11.1037
Autor:
Marc A. Elsliger, Lukas Sušac, Bryan Martin, Andrew Proudfoot, Samit Kumar Dutta, Kurt Wüthrich, Adam Godzik, Biswaranjan Mohanty, Pedro Serrano, Michael Geralt, Ian A. Wilson, Lukasz Jaroszewski
Publikováno v:
The FEBS Journal. 283:3870-3881
For more than a decade, the Joint Center for Structural Genomics (JCSG; www.jcsg.org) worked toward increased three-dimensional structure coverage of the protein universe. This coordinated quest was one of the main goals of the four high-throughput (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d271259cb39a87a8929a6aa26cd72c2
https://doi.org/10.1111/febs.13751
https://doi.org/10.1111/febs.13751
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(50)
The human proteome contains 826 G protein-coupled receptors (GPCR), which control a wide array of key physiological functions, making them important drug targets. GPCR functions are based on allosteric coupling from the extracellular orthosteric drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3a301816e353e6cea57930031ac1c9d
https://pubmed.ncbi.nlm.nih.gov/30463958
https://pubmed.ncbi.nlm.nih.gov/30463958