Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Lukas, Cerveny"'
Autor:
Ondrej Martinec, Carin Biel, Inge A. M. de Graaf, Martin Huliciak, Koert P. de Jong, Frantisek Staud, Filip Cecka, Peter Olinga, Ivan Vokral, Lukas Cerveny
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon assoc
Externí odkaz:
https://doaj.org/article/4656e5a7685c434c9074223607aaa1a1
Autor:
Rona Karahoda, Cilia Abad, Hana Horackova, Petr Kastner, Jonas Zaugg, Lukas Cerveny, Radim Kucera, Christiane Albrecht, Frantisek Staud
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
L-Tryptophan is an essential amino acid and a precursor of several physiologically active metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan metabolism have been identified, giving rise to various molecules of
Externí odkaz:
https://doaj.org/article/bf5ae8ac44a14cc69b141747443a4882
Autor:
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1306 (2021)
Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) and selective serotonin and noradrenaline reuptake inhibitors (SNRIs). W
Externí odkaz:
https://doaj.org/article/2261aa25370146ada0aa93ae87ad7463
Autor:
Miloslav Machacek, Basma Ghazal, Pavel Kubát, Ali Husain, Asaithampi Ganesan, Petr Zimcik, Saad Makhseed, Lukas Cerveny
Publikováno v:
Dalton Transactions. 49:9605-9617
The development of new non-aggregated phthalocyanines bearing multivalent saccharide moieties on their macrocyclic rims is of great interest. Many characteristics, including water-solubility, non-toxicity and others, can be feasibly obtained by these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2668fbb95a24c905b14c1a566454ac17
https://doi.org/10.1039/d0dt01180k
https://doi.org/10.1039/d0dt01180k
Autor:
Lukas Cerveny, Sara Karbanova, Rona Karahoda, Hana Horackova, Lucie Jiraskova, Mohammed Naji Husaen Ali, Frantisek Staud
Publikováno v:
Toxicology and Applied Pharmacology. 463:116427
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18880f2343eecf78ff988b0486ea2f4
https://doi.org/10.1016/j.taap.2023.116427
https://doi.org/10.1016/j.taap.2023.116427
Autor:
Lukas Cerveny, Ales Sorf, Frantisek Staud, Lucie Jirásková, Zuzana Ptackova, Anezka Lalinska, Sara Karbanova
Publikováno v:
Pharmaceutical Research. 37
S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) is routinely used at concentrations of 0.10 μM and 0.10 mM to specifically inhibit transport of nucleosides mediated by equilibrative nucleoside transporters 1 (ENT1) and 2 (ENT2), respectively. We recently sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f79c39455d633d2ed3b4c04b26ad829
https://doi.org/10.1007/s11095-020-2782-5
https://doi.org/10.1007/s11095-020-2782-5
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867:166206
An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is associated with adverse pregnancy outcomes and all HIV-positive pregnant women, regardless of their clinical stage, should receive a combination of antiretroviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f76095a39041db4b676cb0fedce0fe
https://doi.org/10.1016/j.bbadis.2021.166206
https://doi.org/10.1016/j.bbadis.2021.166206
Autor:
Lukas Cerveny, Frantisek Staud, Rona Karahoda, Andreas Matthios, Jurjen Duintjer Tebbens, Marian Kacerovsky, Radim Kučera, Petr Kastner, Cilia Abad, Alexandre Bonnin, Hana Horackova
Publikováno v:
Acta Physiol (Oxf)
Aim Serotonin is crucial for proper foetal development, and the placenta has been described as a 'donor' of serotonin for the embryo/foetus. However, in later stages of gestation the foetus produces its own serotonin from maternally-derived tryptopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd928f83f078b55ac69d114be8a53625
https://pubmed.ncbi.nlm.nih.gov/32311818
https://pubmed.ncbi.nlm.nih.gov/32311818
Publikováno v:
Antimicrobial agents and chemotherapy. 63(11)
P-glycoprotein (ABCB1), an ATP-binding-cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions (DDIs). ABCB1 has been suggested to interact with many antivirals used to treat HIV and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67894b64a3092abe3646f9288d8d2dc
https://pubmed.ncbi.nlm.nih.gov/31481446
https://pubmed.ncbi.nlm.nih.gov/31481446
Publikováno v:
Xenobiotica. 47:77-85
1. Emtricitabine is a nucleoside reverse transcriptase inhibitor used in combination antiretroviral therapy of HIV (cART). Although active transport mechanisms are believed to mediate tubular secretion of the drug into urine, the responsible transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52829c192ee65e86ead04807700af12c
https://doi.org/10.3109/00498254.2016.1158886
https://doi.org/10.3109/00498254.2016.1158886