Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Luka Suzuki"'
Autor:
Masaya Takahashi, Luka Suzuki, Nanase Takahashi, Mayu Hanaue, Masahiro Soda, Tamito Miki, Naoko Tateyama, Shiro Ishihara, Taro Koshiishi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Hypertensive disorders of pregnancy (HDP) are among the major causes of high maternal and fetal/neonatal morbidity and mortality rates. Patients with HDP have significantly elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels
Externí odkaz:
https://doaj.org/article/a0959b9b3df54a72bf49d58440b506d5
Autor:
Masaya Takahashi, Luka Suzuki, Nanase Takahashi, Mayu Hanaue, Masahiro Soda, Tamito Miki, Naoko Tateyama, Shiro Ishihara, Taro Koshiishi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/363c8bf4425e422ab7eb3018a4fb713c
Autor:
Masaki Miura, Takeshi Miyatsuka, Takehiro Katahira, Shugo Sasaki, Luka Suzuki, Miwa Himuro, Yuya Nishida, Yoshio Fujitani, Taka-aki Matsuoka, Hirotaka Watada
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 358-366 (2018)
Background: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. Methods: The role of STAT3 in β-cell neogenesis, induced by
Externí odkaz:
https://doaj.org/article/20f5850a175b4d869092d621298cd32c
Autor:
Ayako Fukunaka, Toshiyuki Fukada, Jinhyuk Bhin, Luka Suzuki, Takamasa Tsuzuki, Yuri Takamine, Bum-Ho Bin, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Hisashi Naito, Takeshi Miyatsuka, Shinzaburo Takamiya, Tsutomu Sasaki, Takeshi Inagaki, Tadahiro Kitamura, Shingo Kajimura, Hirotaka Watada, Yoshio Fujitani
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006950 (2017)
Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a membe
Externí odkaz:
https://doaj.org/article/e2ac5b178082490895f278d07fc8d759
Autor:
Luka Suzuki, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Sho Osonoi, Masaki Miura, Takehiro Katahira, Yoshio Fujitani, Hitoshi Iida, Hiroki Mizukami, Yuya Nishida, Hirotaka Watada
Publikováno v:
Biochemical and Biophysical Research Communications. 611:38-45
Autophagy is known to play a pivotal role in β-cell function. While the lifelong inhibition of autophagy through Atg7 deletion in β cells has been demonstrated to lead to impaired glucose tolerance together with β-cell dysfunction, the temporal as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c7b4aab2e9775d72e5ca9fdb14a33
https://doi.org/10.1016/j.bbrc.2022.04.040
https://doi.org/10.1016/j.bbrc.2022.04.040
Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production
Autor:
Yoshio Fujitani, Luka Suzuki, Hirotaka Watada, Satoru Takeda, Atsuo Itakura, Masaya Takahashi, Yuya Nishida, Hiroki Mizukami, Takeshi Miyatsuka, Masaki Miura, Yuka Wakabayashi, Miwa Himuro, Takehiro Katahira, Ayako Fukunaka, Sho Osonoi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Pancreatic β-cell mass is known to be considerably altered during pregnancy and after parturition in rodents and humans. While β-cell mass increases during pregnancy and starts to return toward its original level after parturition, the cellular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f6fd99c922e6eab6ecad01d31292a2
http://link.springer.com/article/10.1038/s41598-020-61850-1
http://link.springer.com/article/10.1038/s41598-020-61850-1
Autor:
Ayako Fukunaka, Tamotsu Yoshimori, Hirotaka Watada, Shuhei Aoyama, Yuya Nishida, Takeshi Miyatsuka, Luka Suzuki, Yoshio Fujitani, Miwa Himuro
Publikováno v:
Endocrine Journal. 67:1119-1126
Autophagy has been reported to play a crucial role in the maintenance of intracellular homeostasis, including in pancreatic beta cells. Rubicon, which interacts with the phosphoinositide 3-kinase (PI3K) complex, through autophagy-related 14 (ATG14),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef38699e9a3ac3ad42d1830432d2419
https://doi.org/10.1507/endocrj.ej20-0326
https://doi.org/10.1507/endocrj.ej20-0326
Autor:
Hirotaka Watada, Takehiro Katahira, Luka Suzuki, Miwa Himuro, Hiroaki Satoh, Yuya Nishida, Takeshi Miyatsuka, Masaki Miura
Publikováno v:
Biochemical and Biophysical Research Communications. 521:178-183
The emergence of bihormonal (BH) cells expressing insulin and glucagon has been reported under diabetic conditions in humans and mice. Whereas lineage tracing studies demonstrated that glucagon-producing α cells can be reprogrammed into BH cells, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01689591693a08ede07b0c9c17c23c74
https://doi.org/10.1016/j.bbrc.2019.10.100
https://doi.org/10.1016/j.bbrc.2019.10.100
Autor:
Shugo Sasaki, Michelle Y. Y. Lee, Yuka Wakabayashi, Luka Suzuki, Helena Winata, Miwa Himuro, Taka-aki Matsuoka, Iichiro Shimomura, Hirotaka Watada, Francis C. Lynn, Takeshi Miyatsuka
Publikováno v:
Diabetologia. 65(5)
While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3791284cf2d460b70ecdb6f58ed4f2
https://pubmed.ncbi.nlm.nih.gov/35243521
https://pubmed.ncbi.nlm.nih.gov/35243521
Autor:
Miwa Himuro, Luka Suzuki, Yuya Nishida, Takeshi Miyatsuka, Rieko Yazawa, Toshiaki Shimizu, Hidenori Haruna, Shuhei Aoyama, Hirotaka Watada, Isei Tanida, Noriyuki Takubo
Publikováno v:
Biochemical and Biophysical Research Communications. 516:686-692
Autophagy is a mechanism of bulk protein degradation that plays an important role in regulating homeostasis in many organisms. Among several methods for evaluating its activity, a fluorescent reporter GFP-LC3-RFP-LC3ΔG, in which GFP-LC3 is cleaved b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96d2b6217e19eac2451bf17832a2fe7
https://doi.org/10.1016/j.bbrc.2019.06.129
https://doi.org/10.1016/j.bbrc.2019.06.129