Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Luka Drecun"'
Autor:
Shivanthy Pathmanathan, Zhong Yao, Paula Coelho, Robert Valla, Luka Drecun, Caroline Benz, Jamie Snider, Punit Saraon, Ingrid Grozavu, Max Kotlyar, Igor Jurisica, Morag Park, Igor Stagljar
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105419- (2022)
Summary: Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid (MaMTH) to generate a targeted interactome map of its interactions
Externí odkaz:
https://doaj.org/article/0a92c71625da4b51b6403321021367f4
A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies
Autor:
Zhong Yao, Luka Drecun, Farzaneh Aboualizadeh, Sun Jin Kim, Zhijie Li, Heidi Wood, Emelissa J. Valcourt, Kathy Manguiat, Simon Plenderleith, Lily Yip, Xinliu Li, Zoe Zhong, Feng Yun Yue, Tatiana Closas, Jamie Snider, Jelena Tomic, Steven J. Drews, Michael A. Drebot, Allison McGeer, Mario Ostrowski, Samira Mubareka, James M. Rini, Shawn Owen, Igor Stagljar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Serological tests are important diagnostic and disease surveillance tools for addressing the COVID-19 pandemic. Here, the authors present a tri-part Nanoluciferase based assay to detect antibodies against SARS-CoV-2.
Externí odkaz:
https://doaj.org/article/449b1c0635934549a4cf789704798ab6
Autor:
Jamie Snider, Ruth H. Palmer, Ganesh Umapathy, Igor Jurisica, Igor Stagljar, Max Kotlyar, Shivanthy Pathmanathan, Zhong Yao, Farzaneh Aboualizadeh, Jikui Guan, Luka Drecun
Protein-protein interactions (PPIs) play essential roles in Anaplastic Lymphoma Kinase (ALK) signaling. Systematic characterization of ALK interactors helps elucidate novel ALK signaling mechanisms and may aid in the identification of novel therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39c58428b5b2721f4f2f9931f99e227
https://doi.org/10.1016/j.jmb.2021.167283
https://doi.org/10.1016/j.jmb.2021.167283
A Homogeneous Split-Luciferase Assay for Rapid and Sensitive Detection of Anti-SARS CoV-2 Antibodies
Autor:
Igor Stagljar, Shawn Owen, Zhong Yao, Luka Drecun, Farzaneh Aboualizadeh, Sun Jin Kim, Zhijie Li, Emelissa J Valcourt, Kathy Manguiat, Heidi Wood, Simon Plenderleith, Lily Yip, Xinliu Li, Zoe Zhong, Feng Yun Yue, Jamie Snider, Jelena Tomic, Michael A. Drebot, Allison McGeer, Mario Ostrowski, Samira Mubareka, James Rini
To meet the urgent demand for better diagnostic tools to combat the ongoing COVID-19 pandemic, we developed a homogeneous immunoassay to detect IgG antibodies against SARS-CoV-2. This assay is based on a tri-part Nanoluciferase (tNLuc) approach, in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b765ca821cf4349b3de94b1ef065ac
https://doi.org/10.21203/rs.3.rs-115221/v1
https://doi.org/10.21203/rs.3.rs-115221/v1
Autor:
Luka Drecun, Punit Saraon, Brandy D. Hyndman, Lois M. Mulligan, Samira Kheitan, Igor Stagliar, Annika E. Pedersen
Publikováno v:
Cancer Research. 81:2450-2450
The REarranged during Transfection (RET) receptor tyrosine kinase is pivotal for normal tissue development, but is also an oncogene driver involved in several human cancers. Alternative splicing at the 3' end of the RET gene leads to expression of tw
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N
Autor:
Luka Drecun, Shivanthy Pathmanathan, Caroline Benz, Zhong Yao, Yaakov E. Stern, Jamie Snider, Igor Stagljar, Morag Park
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Alan R. Davidson, Luka Drecun, Rachel R. Miller, Victoria Wong, Monique Rehal, Farzaneh Aboualizadeh, Jamie Snider, Mid Eum Lee, Matthew Jessulat, Meirui Li, Mohan Babu, Mandy H. Y. Lam, Viktor Deineko, Mehrab Ali, Hay-Oak Park, Olivia Wong, Bellal Jubran, Igor Stagljar
Publikováno v:
Journal of Molecular Biology. 427:2088-2103
Sho1p, an integral membrane protein, plays a vital role in the high-osmolarity glycerol (HOG) mitogen-activated protein kinase pathway in the yeast Saccharomyces cerevisiae. Activated under conditions of high osmotic stress, it interacts with other H
Autor:
Michael Prakesch, Ahmed Aman, Victoria Wong, Leanne E Wybenga-Groot, Michael F. Moran, Nika Vučković, Adrian G. Sacher, Luka Drecun, Miroslav Samaržija, Alessandro Datti, Nhu-An Pham, Zhong Yao, Gennady Poda, Punit Saraon, Marko Jakopović, Babu Joseph, Jenny Wang, Konstantin Weiss, Nikolina Radulovich, Anna Akhmanova, Jin H Park, Adriana Vučetić, Anna Lyakisheva, Ming-Sound Tsao, Ankit Rai, David Uehling, Farzaneh Aboualizadeh, Jamie Snider, Natasha B. Leighl, Frances A. Shepherd, Richard Marcellus, Rima Al-awar, Igor Stagljar, Yannis Kalaidzidis, Brigitte L. Thériault, Marino Zerial, Shivanthy Pathmanathan, Yuhui Wang
Publikováno v:
Nature Chemical Biology, 16(5), 577. Nature Publishing Group
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug res