Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Luk Van Parijs"'
Autor:
Luk Van Parijs, Borko Javonovic, Larry Wong, Norm D. Smith, Seong-Jin Kim, Robert E. Meyer, Shilajit Kundu, Irwin Park, Yinglu Guo, Qiang Zhang, Thomas L. Jang, Norman M. Greenberg, Ximing J. Yang, Timothy M. Kuzel, Michael R. Pins, Chung Lee
Publikováno v:
The Prostate. 66:235-247
Background TGF-beta is a potent immunosuppressant. High levels of TGF-beta produced by cancer cells have a negative inhibition effect on surrounding host immune cells and leads to evasion of the host immune surveillance and tumor progression. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d30970478215338ae7aed9200e71fd
https://doi.org/10.1002/pros.20340
https://doi.org/10.1002/pros.20340
Autor:
Phillip A. Sharp, Luk Van Parijs, Michael T. McManus, Andrea Ventura, Tyler Jacks, Christopher P. Dillon, Alexander Meissner, Rudolf Jaenisch
Publikováno v:
Proceedings of the National Academy of Sciences. 101:10380-10385
We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA interference. One vector allows for conditional activation, whereas the other permits conditional inactivation of short hairpin RNA (shRNA) expression. The former is bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb762ce03b6db854a93d5a726bb6efc
https://doi.org/10.1073/pnas.0403954101
https://doi.org/10.1073/pnas.0403954101
Autor:
Luk Van Parijs, Wu-Shiun Hou
Publikováno v:
Nature Immunology. 5:583-589
The lifespan of antigen-bearing dendritic cells (DCs) is determined by signals from pathogens and T cells. These signals regulate DC survival by modulating expression of Bcl-2 family proteins. Toll-like receptors and T cell costimulatory molecules bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c4c849e7f04e5ef5f5c501a3b45be7
https://doi.org/10.1038/ni1071
https://doi.org/10.1038/ni1071
Autor:
Giuseppe Sandro Mela, Sebastian Wesselborg, Peter Brossart, Luk Van Parijs, Davide Boy, Franco Patrone, Alessio Nencioni, Ilaria Rocco, Anna Garuti, Alberto Ballestrero
Publikováno v:
Clinical Cancer Research. 10:1463-1470
Purpose: Overexpression of antiapoptotic Bcl-2 family members has recently been related to resistance to chemo/radiotherapy in several human malignancies, particularly lymphomas. Hence, innovative approaches bypassing this resistance mechanism are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352839bba09da3889b87a4bcf4b7a21c
https://doi.org/10.1158/1078-0432.ccr-1365-02
https://doi.org/10.1158/1078-0432.ccr-1365-02
Autor:
Michael Croft, Mary Cheng, Jianxun Song, Shahram Salek-Ardakani, Paul R. Rogers, Luk Van Parijs
Publikováno v:
Nature Immunology. 5:150-158
A brief antigenic stimulus can promote T cell proliferation, but the duration and nature of intracellular signals required for survival are unclear. Here we show that in the absence of OX40 costimulation, antigen-activated CD4+ cells are short-lived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455bef7d6460c9668fa2429b00bd07d8
https://doi.org/10.1038/ni1030
https://doi.org/10.1038/ni1030
Autor:
Nancy A. Dower, Satoshi Takamatsu, Katrin Layer, Xiaoyu Li, Guosheng Lin, David R. Beier, Alessio Nencioni, Timothy Chevassut, Andrey Antov, Wei Hu, Luk Van Parijs, Stacey L. Stang, Janet E. Buhlmann, James C. Stone, Adam Schmucker, Keith B. Elkon, Roderick T. Bronson, Bing Lim
Publikováno v:
Immunity. 19:243-255
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Authors.The authors have agreed to retract the paper because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2ecf9d8e8f45ee00aa7138a8933c89
https://doi.org/10.1016/s1074-7613(03)00209-7
https://doi.org/10.1016/s1074-7613(03)00209-7
Autor:
Mingdi Zhang, Michael T. McManus, Luk Van Parijs, Martin L. Scott, Claudia Sievers, Lili Yang, Melanie Ihrig, Johnny E. Kopinja, Christopher P. Dillon, Adam V. Kwiatkowski, Douglas A. Rubinson, Dina L Rooney, Frank B. Gertler
Publikováno v:
Nature Genetics. 33:401-406
RNA interference (RNAi) has recently emerged as a specific and efficient method to silence gene expression in mammalian cells either by transfection of short interfering RNAs (siRNAs; ref. 1) or, more recently, by transcription of short hairpin RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf403af4092438e15917d4db1eda689
https://doi.org/10.1038/ng1117
https://doi.org/10.1038/ng1117
Publikováno v:
The Journal of Experimental Medicine
Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-kappaB pathway in regulating mature T cell function by using CD4+ T cells from p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e192fd5906569fa0283a0c7e11892a
http://europepmc.org/articles/PMC2193891
http://europepmc.org/articles/PMC2193891
Publikováno v:
The Journal of Experimental Medicine
The effector cytokine interferon gamma (IFN-gamma) may play a role in T cell homeostasis. We have examined the requirement for IFN-gamma in one mechanism that regulates T cell expansion and survival, activation-induced cell death (AICD). CD4(+) T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550e9c29b8076caca23a0c4e4fba219f
https://doi.org/10.1084/jem.20020666
https://doi.org/10.1084/jem.20020666
Publikováno v:
The Journal of Immunology. 169:3485-3491
TGF-β regulation of immune homeostasis has been investigated in the context of cytokine knockout (TGF-β null) mice, in which particular TGF-β isoforms are disrupted throughout the entire organism, as well as in B and T cell-specific transgenic mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bf0d6b30afb843a07ca9181db6ed47
https://doi.org/10.4049/jimmunol.169.7.3485
https://doi.org/10.4049/jimmunol.169.7.3485