Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lukáš Maier"'
Autor:
Václav Němec, Prashant Khirsariya, Pavlína Janovská, Paula Martín Moyano, Lukáš Maier, Petra Procházková, Pavlína Kebková, Tomáš Gybel', Benedict‐Tilman Berger, Apirat Chaikuad, Maria Reinecke, Bernhard Kuster, Stefan Knapp, Vítězslav Bryja, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 62
Autor:
Prashant Khirsariya, Patrik Pospíšil, Lukáš Maier, Miroslav Boudný, Martin Babáš, Ondřej Kroutil, Marek Mráz, Robert Vácha, Kamil Paruch
Publikováno v:
Journal of Medicinal Chemistry. 65:5701-5723
Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of hematological malignancies. Here, we report the design, synthesis, and profiling of new DOT1L inhibitors based on nonroutine carbocyclic C-nucleoside scaffolds.
Autor:
Viktoria Knöbl, Lukas Maier, Stefan Grasl, Carmen Kratzer, Felix Winkler, Vanessa Eder, Hubert Hayden, Maria Amparo Sahagun Cortez, Monika Sachet, Rudolf Oehler, Sophie Frantal, Christian Fesl, Karin Zehetner, Georg Pfeiler, Rupert Bartsch, Florian Fitzal, Christian F. Singer, Martin Filipits, Michael Gnant, Christine Brostjan
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Monocytes comprise subsets of classical, intermediate and non-classical monocytes with distinct anti- or pro-tumor effects in breast cancer (BC). They are modulated by estrogen, and can contribute to BC control by endocrine therap
Externí odkaz:
https://doaj.org/article/67d59ab9099a49d8987574d7fbdf4ebb
Autor:
Venkata Pardha Saradhi Attuluri, Juan Francisco Sánchez López, Lukáš Maier, Kamil Paruch, Hélène S. Robert
Publikováno v:
Plant Reproduction
Key message ClearSee alpha and FAST9 were optimized for imaging Arabidopsis seeds up to the torpedo stages. The methods preserve the fluorescence of reporter proteins and seed shape, allowing phenotyping embryos in intact seeds. Abstract Tissue clear
Autor:
Herbert Waldmann, Jana Flegel, Slava Ziegler, Barbora Valčíková, Stjepan Uldrijan, Sonja Sievers, Michaela Hylsová, Apirat Chaikuad, Stefan Knapp, Benedict-Tilman Berger, Lukáš Maier, Martin Schröder, Vaclav Nemec, Karel Souček, Stanislav Drápela, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 58:1062-1066
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound
Autor:
Ondřej Hylse, Jakub Švenda, Tomas Perecko, Aneta Svobodová, Roman Kučera, Kamil Paruch, Lukáš Kubala, Lukáš Maier
Publikováno v:
Angewandte Chemie International Edition. 56:12586-12589
A 24-step synthesis of (±)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a steri
Autor:
Stanislav Drápela, Karel Souček, Erik Weis, Kamil Paruch, PrashantKumar Khirsariya, Michal Poljak, Santosh Kumar Adla, Ondřej Hylse, Soňa Krajčovičová, Lukáš Maier, Lenka Černová
Publikováno v:
The Journal of Organic Chemistry. 82:3382-3402
Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors-properly substituted cyclopentanones, which can be prepared racemic (in six steps) or optically pure
Autor:
Václav Němec, Stefan Knapp, Apirat Chaikuad, Benedict-Tilman Berger, Stanislav Drápela, Kamil Paruch, Karel Souček, Lukáš Maier
Publikováno v:
European Journal of Medicinal Chemistry. 215:113299
The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of ne
Autor:
Santosh Kumar Adla, Yoshiyuki Mizushina, Kamil Paruch, Michal Babiak, Lukáš Maier, Silvia Kováčová
Publikováno v:
Tetrahedron. 71:7575-7582
Syntheses of carbocyclic analogs of dehydroaltenusin tautomers are reported. Both target compounds, cDHA (2,8-dihydroxy-6-methoxy-10a-methyl-10,10a-dihydrophenanthrene-3,9-dione) and cDHAs (4′,5-dihydroxy-6′-methoxy-2-methylspiro[cyclohexa[2,5]di
Autor:
Bjørn Dalhus, Lukáš Maier, Mari Ytre-Arne, Martin Trbušek, Magnar Bjørås, Marek Nečas, Ondřej Hylse, Kamil Paruch
Publikováno v:
Tetrahedron Letters
Cyclopentane-containing nucleoside analogs with a CC connection between the (heterocyclic) base and the carbocyclic scaffold are quite rare. Herein, we report the synthesis of previously unknown racemic carbocyclic pseudoisocytidine and its analogs,