Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Lukáš Lacina"'
Autor:
Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical i
Externí odkaz:
https://doaj.org/article/60f3248bbe5d4cae877f072b508159d0
Autor:
Vladimír Procházka, Lukáš Lacina, Karel Smetana, Martin Svoboda, Kateřina Skřivanová, Miroslava Beňovská, Jiří Jarkovský, Leoš Křen, Zdeněk Kala
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method A total of 115 patients underwent colorectal
Externí odkaz:
https://doaj.org/article/cc15f446f0e64a3fb365ee7f1237680f
Autor:
Václav Mandys, Alexey Popov, Robert Gürlich, Jan Havránek, Lucie Pfeiferová, Michal Kolář, Jana Vránová, Karel Smetana, Lukáš Lacina, Pavol Szabo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3617 (2023)
Therapy for pancreatic ductal adenocarcinoma remains challenging, and the chances of a complete cure are very limited. As in other types of cancer, the expression and role of miRNAs in controlling the biological properties of this type of tumor have
Externí odkaz:
https://doaj.org/article/1160c0a5380240249736e2e8622f2329
Autor:
Michaela Tesařová, Lenka Peterková, Monika Šťastná, Michal Kolář, Lukáš Lacina, Karel Smetana, Radovan Hynek, Jan Betka, Aleš Vlasák, Petr Lukeš, Zdeněk Fík
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 32 (2022)
Vestibular schwannoma is the most common benign neoplasm of the cerebellopontine angle. It arises from Schwann cells of the vestibular nerve. The first symptoms of vestibular schwannoma include hearing loss, tinnitus, and vestibular symptoms. In the
Externí odkaz:
https://doaj.org/article/5aef85744f6f4f5b84334891727bad21
Autor:
Magdalena Rašková, Lukáš Lacina, Zdeněk Kejík, Anna Venhauerová, Markéta Skaličková, Michal Kolář, Milan Jakubek, Daniel Rosel, Karel Smetana, Jan Brábek
Publikováno v:
Cells, Vol 11, Iss 22, p 3698 (2022)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunit
Externí odkaz:
https://doaj.org/article/d08376423f0544388824b7da040f3086
Autor:
Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana, Milan Jakubek
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1712 (2022)
IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively studied strategy in cancer treatment. We desc
Externí odkaz:
https://doaj.org/article/f251712b9341489a865b0ae337bc3d58
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 964 (2022)
Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affe
Externí odkaz:
https://doaj.org/article/b84f20172f5847319cd1b25fdaf2eeaa
Autor:
Michal Španko, Karolína Strnadová, Aleš Jan Pavlíček, Pavol Szabo, Ondřej Kodet, Jaroslav Valach, Barbora Dvořánková, Karel Smetana, Lukáš Lacina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11027 (2021)
Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it
Externí odkaz:
https://doaj.org/article/56c0657f5723488bb47573ce8dbad148
Autor:
Ondřej Kodet, Kristýna Němejcova, Karolína Strnadová, Andrea Havlínová, Pavel Dundr, Ivana Krajsová, Jiří Štork, Karel Smetana, Lukáš Lacina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7204 (2021)
Therapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma,
Externí odkaz:
https://doaj.org/article/a9edb0962ff046d98c9e66119d5abed5
Autor:
Nikita Abramenko, Fréderic Vellieux, Petra Tesařová, Zdeněk Kejík, Robert Kaplánek, Lukáš Lacina, Barbora Dvořánková, Daniel Rösel, Jan Brábek, Adam Tesař, Milan Jakubek, Karel Smetana
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6551 (2021)
COVID-19 is a pandemic respiratory disease caused by the SARS−CoV−2 coronavirus. The worldwide epidemiologic data showed higher mortality in males compared to females, suggesting a hypothesis about the protective effect of estrogens against sever
Externí odkaz:
https://doaj.org/article/42f6398bf54d43639048e6cc5fc3808e