Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Luiza Madia Lourenco"'
Autor:
Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat
Externí odkaz:
https://doaj.org/article/69534f213e83452c8a4a36b41f55fde1
Autor:
Huw D. Thomas, Celine Cano, Anderson J. Ryan, M. Raymond V. Finlay, Yanyan Jiang, Yan Zhao, Helen L. Reeves, Nicole Phillips, Luiza Madia Lourenco, Catherine E. Willoughby, Gesa Junge, David R. Newell, Joanne M. Munck, Anita Wittner, Lisa Prendergast, Roger J. Griffin, Stephen R. Wedge, Tommy Rennison, Suzanne Kyle, Turner Paul, Elaine Willmore, Susan J. Tudhope, James Pickles
Publikováno v:
The Journal of Clinical Investigation
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity as much as tumor toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfec92227f655feda3619c7b6de2be2
Autor:
Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan
Publikováno v:
BMC Cancer
Mumin, N H, Drobnitzky, N, Patel, A, Lourenco, L M, Cahill, F F, Jiang, Y, Kong, A & Ryan, A J 2019, ' Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer ', BMC Cancer, vol. 19, no. 1, 102 . https://doi.org/10.1186/s12885-019-5295-z
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Mumin, N H, Drobnitzky, N, Patel, A, Lourenco, L M, Cahill, F F, Jiang, Y, Kong, A & Ryan, A J 2019, ' Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer ', BMC Cancer, vol. 19, no. 1, 102 . https://doi.org/10.1186/s12885-019-5295-z
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Background Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat shock pr
Autor:
Luiza Madia Lourenco, Anderson J. Ryan, Fiona Cahill, Neele Drobnitzky, John Moore, Yasmin Shanneik, Marcus Green, Yanyan Jiang, Agata Patel
Publikováno v:
International journal of radiation oncology, biology, physics. 100(3)
Purpose Poly (ADP-ribose) polymerase (PARP) inhibitors have been shown to enhance the radiosensitivity of cancer cells in vitro in a replication-dependent manner. Their in vivo radiosensitizing effects have also been demonstrated in preclinical tumor
Autor:
Neele Drobnitzky, Luiza Madia Lourenco, Fiona Cahill, Samantha Olyha, Sureyya Corbacioglu, Agata Patel, Anderson J. Ryan, Yanyan Jiang, Amalina Mumin
Publikováno v:
Molecular Cancer Therapeutics. 16:B30-B30
Non-small cell lung cancer (NSCLC) patients with activating mutations in the epidermal growth factor receptor (EGFR) gene generally show good responses to therapy with EGFR tyrosine kinase inhibitors (EGFR-TKIs). Unfortunately resistance emerges duri
Autor:
Luiza Madia Lourenco, Fiona Cahill, Sivan M. Bokobza, Yanyan Jiang, Anika M. Weber, Nuramalina H. Mumin, Thomas M. Ashton, Aoife M. Devery, Anderson J. Ryan, Neele Drobnitzky
Publikováno v:
Molecular Cancer Therapeutics. 14:C114-C114
Lung cancer is the leading cause of cancer related death worldwide and adenocarcinoma is the most prevalent subtype. LKB1 (STK11) is the second most commonly altered tumour suppressor in adenocarcinoma and is inactivated in 17% of samples (1). LKB1 i
Autor:
Anderson J. Ryan, Sivan M. Bokobza, Fiona Cahill, Luiza Madia Lourenco, Neele Drobnitzky, Yanyan Jiang, Aoife Vaughan, Anthony Kong, Anika M. Weber, Nuramalina H. Mumin
Publikováno v:
Molecular Cancer Therapeutics. 14:B88-B88
Background: Triple negative breast cancer (TNBC), which accounts for 10-17% of all breast cancers, is challenging to treat due to its heterogeneity and the absence of identified targeted therapies. Heat shock protein 90 kDa (Hsp90) is a molecular cha
Autor:
Ana L Gomes, Paul Kinchesh, Stuart Gilchrist, Philip D Allen, Luiza Madia Lourenço, Anderson J Ryan, Sean C Smart
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212172 (2019)
The identification and measurement of tumours is a key requirement in the study of tumour development in mouse models of human cancer. Disease burden in autochthonous tumours, such as those arising in the lung, can be seen with non-invasive imaging,
Externí odkaz:
https://doaj.org/article/0cdd933fe5b64c7eafda8fdc20e58782