Autoantibodies and Malaria: Where We Stand? Insights Into Pathogenesis and Protection

Autor: Luiza Carvalho Mourão, Gustavo Pereira Cardoso-Oliveira, Érika Martins Braga

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Autoantibodies are frequently reported in patients with malaria, but whether they contribute to protection or to pathology is an issue of debate. A large body of evidence indicates that antibodies against host-self components are associated to malari

Externí odkaz: https://doaj.org/article/dc5a9c8686f14276a613d4f6fdeccc8b

Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

Autor: Ubirajara Agero, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Érika Martins Braga, Cor Jesus Fernandes Fontes, Jamila da Silva Sultane Aboobacar, Luiza Carvalho Mourão, Beatriz Carolina Medeiros Rodrigues, Paula Magda da Silva Roma

Publikováno v: Microbes and Infection. 22:379-383

Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a05ba2075d6747190078e4a245b751
https://doi.org/10.1016/j.micinf.2020.02.003

Preliminary assessment of anti-α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection

Autor: Gustavo Pereira Cardoso-Oliveira, M. G. Finn, Zélia Barbosa de Almeida Coelho, Érika Martins Braga, Alexandre F. Marques, Cor Jesus Fernandes Fontes, Carlos Sanhueza-Chavez, Luiza Carvalho Mourão, Beatriz Carolina Medeiros Rodrigues, Robert Hincapie

Publikováno v: Memórias do Instituto Oswaldo Cruz, Volume: 114, Article number: e190145, Published: 04 JUL 2019
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz., Vol 114

Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa002ee01e9e3a8f5c63da26baf880c2
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100412&lng=en&tlng=en

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

Autor: Érika Martins Braga, Gisely Cardoso de Melo, Marcus V. G. Lacerda, Thiago Castro-Gomes, Luiza Carvalho Mourão, Wuelton Marcelo Monteiro

Publikováno v: Infection and Immunity. 82:3990-4000

The pathogenesis of malaria is complex, generating a broad spectrum of clinical manifestations. One of the major complications and concerns in malaria is anemia, which is responsible for considerable morbidity in the developing world, especially in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f466dc67d27e0a3bcca90f1dada52a
https://doi.org/10.1128/iai.01972-14

Anti-erythrocyte antibodies may contribute to anaemia in Plasmodium vivax malaria by decreasing red blood cell deformability and increasing erythrophagocytosis

Autor: Jamila da Silva Sultane Aboobacar, Oscar N. Mesquita, Zélia Barbosa de Almeida, Paula Magda da Silva Roma, Marcelo P. Bemquerer, Cor Jesus Fernandes Fontes, Camila Maia Pantuzzo Medeiros, Luiza Carvalho Mourão, Ubirajara Agero, Érika Martins Braga

Publikováno v: Malaria Journal

Background Plasmodium vivax accounts for the majority of human malaria infections outside Africa and is being increasingly associated in fatal outcomes with anaemia as one of the major complications. One of the causes of malarial anaemia is the augme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0a9f3eb0dafc30836647243576131b
https://pubmed.ncbi.nlm.nih.gov/27488382