Monoconjugation of Human Amylin with Methylpolyethyleneglycol.

Autor: Tháyna Sisnande, Luiz Henrique Guerreiro, Raquel R Braga, Luana Jotha-Mattos, Luiza C S Erthal, Priscilla Tinoco, Bruno M Ferreira, Luís Maurício T R Lima

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0138803 (2015)

Amylin is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable in diabetes mellitus. Protein conjugation w

Externí odkaz: https://doaj.org/article/83c6ecb7e2bd407cb008be96bcee7065

Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer

Autor: M. Dolores Santana, José Ruiz, Jérémy Morand, Marina Martínez-Carmona, María Vallet-Regí, Yurii K. Gun'ko, Enrique Ortega, Luiza C. S. Erthal, Quy P. Ho, Ana García, Eduardo Ruiz-Hernández

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
Instituto de Salud Carlos III (ISCIII)
Inorg Chem
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Inorganic Chemistry

In the process of synthesis of a new drug, as important as the drug itself is the formulation used, because the same compound can present a very different efficacy depending on how it is administered. In this work, we demonstrate how the antitumor ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a832b2fa5f2133fb9d3c10c7dac74d4
https://doi.org/10.1021/acs.inorgchem.0c01436

The toxic nature of murine amylin and the immune responsivity of pancreatic islet to conformational antibody in mice

Autor: Luiza C. S. Erthal, Bernardo Miguel de Oliveira Pascarelli, Luana Jotha-Mattos, Kleber L.A. Souza, Luís Maurício T.R. Lima, Sabrina Alves dos Reis, Cinthia Melo Costa, Flávio Alves Lara

Publikováno v: Molecular and Cellular Biochemistry. 447:1-7

The human amylin is a pancreatic peptide hormone cosecreted with amylin and found in hyperhormonemic state along with insulin in subclinical diabetes. Amylin has been associated with the pathology of type 2 diabetes, particularly due to its ability t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98191ad6aa4a5895f036c203016651bd
https://doi.org/10.1007/s11010-018-3288-x

Amylin Conjugation with Methoxyl Polyethyleneglycol

Autor: Mariana F. A. N. Guterres, Bruno Melo-Ferreira, Luiza C. S. Erthal, Luiz Henrique Guerreiro, Luís Maurício T.R. Lima

Publikováno v: Protein & Peptide Letters. 20:1264-1271

We modified amylin chemically by conjugating methoxyl polyethyleneglycol succinimidyl carbonate (mPEGSC) of varying molecular weights (1 kDa, 2 kDa and 5 kDa). The reaction occurred within a few minutes, resulting in at least four distinct PEGylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8700abd371cd3dce328e7bd18dea3e71
https://doi.org/10.2174/09298665113209990067

Amyloidogenesis of the amylin analogue pramlintide

Autor: Luiza C. S. Erthal, Luís Maurício T.R. Lima, Giselle N. Fontes, Dayana Cabral da Silva

Publikováno v: Biophysical chemistry. 219

Amylin is a pancreatic peptide hormone co-secreted along with insulin by the β-cells. It is found in amyloid deposits in both type 2 diabetic individuals and elder non-diabetic. The triple proline amylinomimetic compound (25,28,29-Pro-human amylin)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfb84a2efc5215cdc971a7e59e6c61e
https://pubmed.ncbi.nlm.nih.gov/27665170