Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Luiz O.F. Penalva"'
1
Akademický článek
The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes
Autor: Rodrigo A. S. Barreiro, Gabriela D. A. Guardia, Fabiana M. Meliso, Xiufen Lei, Wei-Qing Li, Andre Savio, Martin Fellermeyer, Helena B. Conceição, Rafael L. V. Mercuri, Tesha Landry, Mei Qiao, Lorea Blazquez, Jernej Ule, Luiz O.F. Penalva, Pedro A. F. Galante
Publikováno v: RNA Biology, Vol 20, Iss 1, Pp 311-322 (2023)
The exon junction complex (EJC) plays key roles throughout the lifespan of RNA and is particularly relevant in the nervous system. We investigated the roles of two EJC members, the paralogs MAGOH and MAGOHB, with respect to brain tumour development.
Externí odkaz: https://doaj.org/article/4fd5893722cd47b3862c3d6e6e3796d7
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2
Akademický článek
IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC
Autor: Hanane Ennajdaoui, Jonathan M. Howard, Timothy Sterne-Weiler, Fereshteh Jahanbani, Doyle J. Coyne, Philip J. Uren, Marija Dargyte, Sol Katzman, Jolene M. Draper, Andrew Wallace, Oscar Cazarez, Suzanne C. Burns, Mei Qiao, Lindsay Hinck, Andrew D. Smith, Masoud M. Toloue, Benjamin J. Blencowe, Luiz O.F. Penalva, Jeremy R. Sanford
Publikováno v: Cell Reports, Vol 15, Iss 9, Pp 1876-1883 (2016)
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cel
Externí odkaz: https://doaj.org/article/4c64e93800e542b284ebe625acd620b5
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3
Akademický článek
Biotinylated tags for recovery and characterization of ribonucleoprotein complexes
Autor: Luiz O.F. Penalva, Jack D. Keene
Publikováno v: BioTechniques, Vol 37, Iss 4, Pp 604-610 (2004)
Determining the in vivo targets of RNA-binding proteins and characterizing the posttranscriptional networks in which they participate constitute major challenges in the post-genomic era. An important step in this direction is the development of metho
Externí odkaz: https://doaj.org/article/bbfcc742856e4361ad8b97e3ecd556c3
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5
Data from ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State
Autor: Luiz O.F. Penalva, Erzsebet Kokovay, Vishwanath R. Iyer, Alexander Pertsemlidis, Juan Gabriel Garcia, Suzanne Burns, Mei Qiao, Haridha Shivram, Liqin Du, Adam Kosti
13-Cis-retinoic acid (RA) is typically used in postremission maintenance therapy in patients with neuroblastoma. However, side effects and recurrence are often observed. We investigated the use of miRNAs as a strategy to replace RA as promoters of di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a497e05c963a98af76838e86b216bf
https://doi.org/10.1158/1541-7786.c.6540238.v1
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9
Supplementary Figure Legends from ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State
Autor: Luiz O.F. Penalva, Erzsebet Kokovay, Vishwanath R. Iyer, Alexander Pertsemlidis, Juan Gabriel Garcia, Suzanne Burns, Mei Qiao, Haridha Shivram, Liqin Du, Adam Kosti
Figure S1. Knockdown efficiency 48 h after reverse transfection. Figure S2. miR-124 directly binds ELF4 and regulates ELF4 expression. Figure S3. ELF4 ectopic expression antagonizes the effect of miR-124 on differentiation of KELLY cells. Figure S4.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51783e42ed5f3426bc11aa81d90e84f6
https://doi.org/10.1158/1541-7786.22512448.v1
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