Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Luiz O F Penalva"'
Autor:
Maria Virginia Giolito, Serguei Bodoirat, Theo La Rosa, Mathieu Reslinger, Gabriela D. A. Guardia, Jana Mourtada, Leo Claret, Alain Joung, Pedro A. F. Galante, Luiz O. F. Penalva, Michelina Plateroti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)
Abstract Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug resistance. Our previous studies showed the importance of thyroid
Externí odkaz:
https://doaj.org/article/47036ca150204b2daf31ed90fa454bc6
Autor:
Saleh Tamim, Dat T Vo, Philip J Uren, Mei Qiao, Eckart Bindewald, Wojciech K Kasprzak, Bruce A Shapiro, Helder I Nakaya, Suzanne C Burns, Patricia R Araujo, Ichiro Nakano, Agnes J Radek, Scott Kuersten, Andrew D Smith, Luiz O F Penalva
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85591 (2014)
miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma
Externí odkaz:
https://doaj.org/article/07dfca16fddd4fbc9d890bfd951dd082
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/1c2bf678ef014f9386663e6a1e67bea6
Autor:
Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown, Christopher G. Hubert
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors including GBM, but how lipid me
Externí odkaz:
https://doaj.org/article/f740fb738c5c45e4ad68a8ab8f9b28c9
Autor:
Antoine Baudin, Alma K. Moreno-Romero, Xiaoping Xu, Emily E. Selig, Luiz O. F. Penalva, David S. Libich
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
RNA binding proteins (RBPs) are essential for critical biological processes such as translation regulation and mRNA processing, and misfunctions of these proteins are associated with diseases such as cancer and neurodegeneration. SERBP1 (SERPINE1 mRN
Externí odkaz:
https://doaj.org/article/892ddfb4047f4422a1a3ad0beee4f26b
Autor:
Mirella Baroni, Gabriela D. A. Guardia, Xiufen Lei, Adam Kosti, Mei Qiao, Tesha Landry, Karl Mau, Pedro A. F. Galante, Luiz O. F. Penalva
Publikováno v:
Cells, Vol 11, Iss 1, p 56 (2021)
Medulloblastoma is the most common malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved survival in recent years, but patients are frequently left with devastating neurocognitive and other sequelae. Pa
Externí odkaz:
https://doaj.org/article/142f5cc06b774d00ab977b226c24654e
Autor:
Rodrigo A. S. Barreiro, Gabriela D. A. Guardia, Fabiana M. Meliso, Xiufen Lei, Wei-Qing Li, Andre Savio, Martin Fellermeyer, Helena B. Conceição, Rafael L. V. Mercuri, Tesha Landry, Mei Qiao, Lorea Blazquez, Jernej Ule, Luiz O. F. Penalva, Pedro A. F. Galante
The exon junction complex (EJC) plays key roles throughout the lifespan of RNA and is particularly relevant in the nervous system. We investigated the roles of two EJC members, the paralogs MAGOH and MAGOHB, with respect to brain tumor development. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dceb6689616eb1949fcc9f23da8b8991
https://doi.org/10.1101/2022.12.20.521107
https://doi.org/10.1101/2022.12.20.521107
Autor:
Jeremy R. Sanford, Luiz O. F. Penalva
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-2 (2017)
Abstract A new study investigates how microRNAs affect the binding of proteins to RNA.
Externí odkaz:
https://doaj.org/article/4d403361fe3a4334a5e4811cad817b12
Autor:
Mitzli X. Velasco, Allison N. Tegge, Bruna R. Correa, Adam Kosti, Erzsebet Kokovay, Pedro A. F. Galante, Greco Hernández, Luiz O. F. Penalva, Gabriela D A Guardia, Marcia C. Santos, Mei Qiao
Publikováno v:
RNA
RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d75871226acaa7feece3b367dfdd133
https://doi.org/10.1261/rna.069211.118
https://doi.org/10.1261/rna.069211.118
Autor:
H. Alex Brown, J. Mark Brown, Jeremy N. Rich, Justin D. Lathia, Luiz O. F. Penalva, Briana C. Prager, Arnon Møldrup Knudsen, Sajina Shakya, Christopher G. Hubert, Bjarne Winther Kristensen, Anthony D. Gromovsky, James S. Hale, Lisa C. Wallace
Publikováno v:
Shakya, S, Gromovsky, A D, Hale, J S, Knudsen, A M, Prager, B, Wallace, L C, Penalva, L O F, Brown, H A, Kristensen, B W, Rich, J N, Lathia, J D, Brown, J M & Hubert, C G 2021, ' Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches ', Acta Neuropathologica Communications, vol. 9, 101 . https://doi.org/10.1186/s40478-021-01205-7
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
BackgroundGlioblastoma (GBM) is marked by cellular heterogeneity, including metabolic heterogeneity, that varies among cellular microenvironments in the same tumor. Altered cellular metabolism in cancer is well-established, but how lipid metabolism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f771c8bce9d113f49f80845ee84e7a6e
https://findresearcher.sdu.dk:8443/ws/files/183278150/s40478_021_01205_7.pdf
https://findresearcher.sdu.dk:8443/ws/files/183278150/s40478_021_01205_7.pdf