Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Luiz C. Godoy"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Saima M. Sidik, Dylan Valleau, Yamilex Acevedo-Sánchez, Luiz C. Godoy, Charisse Flerida A. Pasaje, My-Hang Huynh, Vern B. Carruthers, Jacquin C. Niles, Sebastian Lourido
Apicomplexan parasites discharge specialized organelles called rhoptries upon host cell contact to mediate invasion. The events that drive rhoptry discharge are poorly understood, yet essential to sustain the apicomplexan parasitic life cycle. Rhoptr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cd3217756f9211693c1a2d57e98967
https://doi.org/10.1101/2022.11.28.518173
https://doi.org/10.1101/2022.11.28.518173
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Autor:
Paulo C Manzig, Alexander W A Kellner, Luiz C Weinschütz, Carlos E Fragoso, Cristina S Vega, Gilson B Guimarães, Luiz C Godoy, Antonio Liccardo, João H Z Ricetti, Camila C de Moura
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e100005 (2014)
A pterosaur bone bed with at least 47 individuals (wing spans: 0.65-2.35 m) of a new species is reported from southern Brazil from an interdunal lake deposit of a Cretaceous desert, shedding new light on several biological aspects of those flying rep
Externí odkaz:
https://doaj.org/article/9b71d6ecd07d4746bbce126799ce8af0
Publikováno v:
Proceedings of the National Academy of Sciences. 109:20373-20378
Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and elevated levels of nitrotyrosine, a product derived from NO. Although several lin
Autor:
Karina Ckless, Mariano Janiszewski, Marcia C. Jurado, Daniella Oxer, Luiz C. Godoy, Ana Iochabel Soares Moretti, Irineu Tadeu Velasco, Francisco R.M. Laurindo, Heraldo Possolo de Souza
Publikováno v:
Shock. 33:626-633
Signal transduction through the surface molecule CD40 is critical for cellular activation in immunoinflammatory states such as sepsis. The mechanisms regulating this pathway are not completely understood. Because CD40 displays potentially regulatory
Autor:
R.R. Novaes e Brito, B.H. De Lorenzo, José Daniel Lopes, Luiz C. Godoy, Mario Mariano, Rosana L. Pagano, D.M. Grosso, M.A. Amorim-Dias
Publikováno v:
Immunobiology. 215:341-347
The clearance of apoptotic cells by phagocytes is a fundamental process during tissue remodeling and resolution of inflammation. In turn, the phagocytosis of apoptotic cells generates signals that suppress pro-inflammatory activation of macrophages.
Autor:
Chun-Qi Li, Laura J. Trudel, Min Young Kim, Gerald N. Wogan, Apinya Thiantanawat, Luiz C. Godoy
Publikováno v:
Proceedings of the National Academy of Sciences. 106:14547-14551
The transcription factor NF-E2-related nuclear factor 2 (Nrf2) regulates expression of genes that protect cells from oxidative damage. Here, we characterized nitric oxide (•NO)-induced Nrf2–Kelch-like ECH-associated protein 1 (Keap1) signaling an
Autor:
Ronni Rômulo Novaes e Brito, José Daniel Lopes, Beatriz H. P. De Lorenzo, Luiz C. Godoy, Mario Mariano
Publikováno v:
Immunology Letters. 114:110-118
Since B-1 cells were first described, their origin and function remain controversial. Given the ability to produce natural antibodies and large amounts of IL-10, there is a consensus about their role in innate immunity. More recently, however, B-1 ce
Autor:
Choon Nam Ong, Gerald N. Wogan, Luiz C. Godoy, Steven R. Tannenbaum, Kodihalli C. Ravindra, Chang Cheng, Wanxing Eugene Ho, John S. Wishnok, W.S. Fred Wong
The anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua. It is hypothesized to attenuate allergic asthma via inhibition of multiple signaling pathways. We us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0841d9ab0deb5bfd76f5c58fa370a49
https://europepmc.org/articles/PMC5480315/
https://europepmc.org/articles/PMC5480315/