Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Luiz C, Dias"'
Autor:
Brian W. Slafer, Marco A. Dessoy, Ramon G. de Oliveira, Maria C. Mollo, Eun Lee, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L. G. Ferreira, Renata Krogh, Adriano D. Andricopulo, Luiza R. Cruz, Charles E. Mowbray, Jadel M. Kratz, Luiz C. Dias
Publikováno v:
ACS Omega, Vol 9, Iss 20, Pp 22360-22370 (2024)
Externí odkaz:
https://doaj.org/article/181f8460774544aa8d922443939c65c7
Autor:
Ivani Pauli, Celso de O. Rezende Jr., Brian W. Slafer, Marco A. Dessoy, Mariana L. de Souza, Leonardo L. G. Ferreira, Abraham L. M. Adjanohun, Rafaela S. Ferreira, Luma G. Magalhães, Renata Krogh, Simone Michelan-Duarte, Ricardo Vaz Del Pintor, Fernando B. R. da Silva, Fabio C. Cruz, Luiz C. Dias, Adriano D. Andricopulo
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite’s life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus, inhibition
Externí odkaz:
https://doaj.org/article/8b05c18bef4c4cee9ab7ee11d594e168
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs that are currently approved for its treatment, benznidazole and nifurtimox, have c
Externí odkaz:
https://doaj.org/article/c76f51040f3544ce95ce570ee07e311c
Autor:
Rafael A. A. Ferreira, Ivani Pauli, Thiago S. Sampaio, Mariana L. de Souza, Leonardo L. G. Ferreira, Luma G. Magalhães, Celso de O. Rezende, Rafaela S. Ferreira, Renata Krogh, Luiz C. Dias, Adriano D. Andricopulo
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas di
Externí odkaz:
https://doaj.org/article/5b6ce0ac4eb343cfa71241d2fba24483
Autor:
PABLO D.G. MARTINEZ, SUSANN H. KRAKE, MAITIA L. POGGI, SIMON F. CAMPBELL, PAUL A. WILLIS, LUIZ C. DIAS
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 90, Iss 1 suppl 2, Pp 1215-1231 (2018)
ABSTRACT Combination therapy drugs are considered a fundamental way to control malaria as it mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently, this type of therapy constitutes a driving force for the discove
Externí odkaz:
https://doaj.org/article/1897375c92ae4140bf0ee66211c65bbe
Publikováno v:
Química Nova, Vol 36, Iss 10, Pp 1552-1556 (2013)
In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.; Andrade, J. B.; Vieira, P. C. Quim. Nova 2012, 35, 2092], the authors highlighted the importa
Externí odkaz:
https://doaj.org/article/9f7910328f8e4d3c80adc8045526c2df
Autor:
Renata Krogh, Rocio Marisol Espinoza Chávez, Leonardo L. G. Ferreira, Celso O. R. Junior, B. W. Slafer, Luma G. Magalhães, Luiz C. Dias, Mariana L. de Souza, Glaucius Oliva, Rafaela Salgado Ferreira, Fabio C. Cruz, Adriano D. Andricopulo
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. S
Autor:
Luiz C. Dias, Airton G. Salles Jr.
Publikováno v:
Química Nova, Vol 33, Iss 10, Pp 2032-2037 (2010)
This work describes an overview of our synthesis of pteridic acids A and B and discloses some interesting results related to the lithium enolate-mediated aldol reaction used as key step to set up the C5-C15 fragment of these natural products. This fi
Externí odkaz:
https://doaj.org/article/2872b8a3f32541d2adc3bfaee3a32561
Autor:
Jailson B. de Andrade, Luiz C. Dias
Publikováno v:
Química Nova, Vol 33, Iss 10, Pp 2015-2019 (2010)
Hans Viertler, a visionary, an example of institutional commitment, a great scientist, excellent and dedicated teacher, highly respected as a professional and admired for his leadership, wisdom, generosity, good humor, professional capacity, and bala
Externí odkaz:
https://doaj.org/article/81e8faaa30c54e78a5cb9eac1c53de9e