Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Luiz Augusto Basso"'
Autor:
Bruna Coelho de Andrade, Gaby Renard, Adriano Gennari, Leonardo Luís Artico, José Ricardo Teixeira Júnior, Daniel Kuhn, Priscila Pini Zenatti Salles, Claucia Fernada Volken de Souza, Gustavo Roth, Jocelei Maria Chies, José Andrés Yunes, Luiz Augusto Basso
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34951-34963 (2024)
Externí odkaz:
https://doaj.org/article/5fce0fd996774cbeaeb3d880bce646a4
Autor:
Alexia de Matos Czeczot, Mauro Neves Muniz, Marcia Alberton Perelló, Éverton Edésio Dinis Silva, Luís Fernando Saraiva Macedo Timmers, Andresa Berger, Laura Calle Gonzalez, Guilherme Arraché Gonçalves, Sidnei Moura, Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The crystallographic structure of the FolB enzyme from Mycobacterium tuberculosis (MtFolB), complexed with its inhibitor 8-mercaptoguanine (8-MG), was elucidated at a resolution of 1.95 Å. A novel series of S8-functionalized 8-MG derivatives were sy
Externí odkaz:
https://doaj.org/article/c2c86a72e6544669bcd7eb8afcc9a3b3
Autor:
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro, Vincent Delorme
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available. The discovery of compounds targeting the essential folate synthesis pathwa
Externí odkaz:
https://doaj.org/article/f86800fbdee447ed8317cac3db0afcf5
Autor:
Leonardo Kras Borges Martinelli, Mariane Rotta, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso
Publikováno v:
Future Pharmacology, Vol 3, Iss 2, Pp 379-391 (2023)
The enoyl reductase from Mycobacterium tuberculosis (MtInhA) was shown to be a major target for isoniazid, the most prescribed first-line anti-tuberculosis agent. The MtInhA (EC 1.3.1.9) protein catalyzes the hydride transfer from the 4S hydrogen of
Externí odkaz:
https://doaj.org/article/e6d6dbf54ff241988628f0712d1dedee
Autor:
Gisele Cassão, Krist Helen Antunes, João Ismael Budelon Gonçalvez, Leonardo Duarte Santos, Bruno Lopes Abbadi, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Christian Pasquali, Renato T. Stein, Ana Paula Duarte de Souza
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
OM-85 is a bacterial lysate from common respiratory tract pathogens, with an excellent safety profile, widely used to prevent recurrent respiratory tract infections. Several studies have been reporting the immunomodulating properties and antiviral ro
Externí odkaz:
https://doaj.org/article/65130d6acd124b37b7a0b73ab7087035
Autor:
Alexia de Matos Czeczot, Candida Deves Roth, Rodrigo Gay Ducati, Kenia Pissinate, Raoní Scheibler Rambo, Luís Fernando Saraiva Macedo Timmers, Bruno Lopes Abbadi, Fernanda Souza Macchi, Víctor Zajaczkowski Pestana, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 847-855 (2021)
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycoba
Externí odkaz:
https://doaj.org/article/adfbb94f578e4e9eae055faaa791c0f4
Autor:
Guilherme Arraché Gonçalves, Flávio Castro do Nascimento, Sidnei Moura e Silva, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100539- (2022)
N-phenethylquinazolin-4-amines have emerged as potential Mycobacterium tuberculosis cytochrome bd oxidase inhibitors and attractive scaffolds in tuberculosis drug discovery programs. The classical two-step strategy of chlorination-amination to synthe
Externí odkaz:
https://doaj.org/article/5ba46565da434edc813a4e8e27121e37
Autor:
Mario Alejandro Duque-Villegas, Bruno Lopes Abbadi, Paulo Ricardo Romero, Letícia Beatriz Matter, Luiza Galina, Pedro Ferrari Dalberto, Valnês da Silva Rodrigues-Junior, Rodrigo Gay Ducati, Candida Deves Roth, Raoní Scheibler Rambo, Eduardo Vieira de Souza, Marcia Alberton Perello, Héctor Ricardo Morbidoni, Pablo Machado, Luiz Augusto Basso, Cristiano Valim Bizarro
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT The epidemiological importance of mycobacterial species is indisputable, and the necessity to find new molecules that can inhibit their growth is urgent. The shikimate pathway, required for the synthesis of important bacterial metabolites, r
Externí odkaz:
https://doaj.org/article/7923956a598648dcb7e2d9179f3e718c
Autor:
Nathalia D. de Moura Sperotto, Rodrigo Braccini Madeira Silva, Marcia Alberton Perelló, Ana Flávia Borsoi, Adilio da Silva Dadda, Candida Deves Roth, Raquel Dal Sasso Freitas, Ana Paula Duarte de Souza, Deise do Nascimento de Freitas, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Débora Dreher Nabinger, Stefani Altenhofen, Carla Denise Bonan, Valnês S. Rodrigues-Junior, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111672- (2021)
Human thymidine phosphorylase (hTP) is overexpressed in several solid tumors and is commonly associated with aggressiveness and unfavorable prognosis. 6-(((1,3-Dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione (CPBMF-223) is a nonc
Externí odkaz:
https://doaj.org/article/6974146b079f4acc9c3fe70b9fb77449
Autor:
Estevão Silveira Grams, Alessandro Silva Ramos, Mauro Neves Muniz, Raoní S. Rambo, Marcia Alberton Perelló, Nathalia Sperotto, Laura Calle González, Lovaine Silva Duarte, Luiza Galina, Adilio Silva Dadda, Guilherme Arraché Gonçalves, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Publikováno v:
Molecules, Vol 27, Iss 8, p 2556 (2022)
Tuberculosis remains a global health problem that affects millions of people around the world. Despite recent efforts in drug development, new alternatives are required. Herein, a series of 27 N-(4-(benzyloxy)benzyl)-4-aminoquinolines were synthesize
Externí odkaz:
https://doaj.org/article/aef2189898f3466dbf2421b59ab0d6b7