Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Luiz A. Poletto Chaves"'
Autor:
Fabiano Pinto Saggioro, Camila Maria de Melo, Luiz Artur Poletto Chaves, Jeremy A. Squire, Andre L. Caliari
Publikováno v:
Cancer Research. 81:1818-1818
Prostate cancer (PCa) is considered immunologically cold with a tumor microenvironment (TME) that evades effective immune responses. PTEN loss and TMPRSS2-ERG fusion are common somatic mutations in PCa and both alterations have recently been suggeste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbbf1e64a1d4589b729b98746a576091
https://doi.org/10.1158/1538-7445.am2021-1818
https://doi.org/10.1158/1538-7445.am2021-1818
Publikováno v:
The Journal of General Physiology
Both the catalytically active and inactive interfacial ATP-binding sites open at least 8 Å during CFTR channel closure.
Cystic fibrosis transmembrane conductance regulator (CFTR) channel opening and closing are driven by cycles of adenosine tri
Cystic fibrosis transmembrane conductance regulator (CFTR) channel opening and closing are driven by cycles of adenosine tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e308149d44c3172a50a7d7f3f087b1
https://doi.org/10.1085/jgp.201411347
https://doi.org/10.1085/jgp.201411347
Publikováno v:
Biophysical Journal. 102(3)
CFTR channel gating is driven by cyclic formation and dissociation of a head-to-tail NBD1-NBD2 heterodimer enclosing two composite ATP sites, one catalytically active and one dead. NBD separation at the active site is believed to follow ATP hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b3bec1a8aef8de96e41b1d3bdf89ac
Autor:
Luiz A. Poletto Chaves
Publikováno v:
Biophysical Journal. 98(3)
Opening and closing of a CFTR channel is accompanied by ATP-driven formation and hydrolysis-triggered disruption of a head-to-tail NBD1-NBD2 heterodimer where composite interfacial sites, between the Walker motifs of one NBD and the LSGGQ-like (ABC s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c4d6348a08a78370ee2dae2ff586a5
Publikováno v:
Pflugers Archiv : European journal of physiology. 457(2)
Production and secretion of testosterone in Leydig cells are mainly controlled by the luteinizing hormone (LH). Biochemical evidences suggest that the activity of Cl(-) ions can modulate the steroidogenic process, but the specific ion channels involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9091bab2bc11fcab65546aeda33ad888
https://pubmed.ncbi.nlm.nih.gov/18574591
https://pubmed.ncbi.nlm.nih.gov/18574591
Publikováno v:
American journal of physiology. Cell physiology. 290(4)
ATP-activated currents were studied in Leydig cells of mice with the patch-clamp technique. Whole cell currents were rapidly activating and slowly desensitizing (55% decrement from the peak value on exposure to 100 μM ATP for 60 s), requiring 3 min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de033e2582d331ddaf3b6463261dcca8
https://pubmed.ncbi.nlm.nih.gov/16291815
https://pubmed.ncbi.nlm.nih.gov/16291815