Zobrazeno 1 - 10
of 457
pro vyhledávání: '"Luiz, Belardinelli"'
Autor:
Alexander Burashnikov, Jose M. Di Diego, Bence Patocskai, Luiz Belardinelli, Charles Antzelevitch
Publikováno v:
Heart Rhythm. 20:S144-S145
Publikováno v:
Circulation. 146(9)
Autor:
Sander Verheule, Arne van Hunnik, Stef Zeemering, Dragan Opacic, Luiz Belardinelli, Arvinder Dhalla, Ulrich Schotten
Publikováno v:
Heart Rhythm, 18(4), 615-622. Elsevier Science
Background There is still an unmet need for pharmacologic treatment of atrial fibrillation (AF) with few effects on ventricular electrophysiology. Ranolazine is an antiarrhythmic drug reported to have strong atrial selectivity. Objective The purpose
Autor:
Yejia Song, Luiz Belardinelli
Publikováno v:
Physiological Reports, Vol 5, Iss 10, Pp n/a-n/a (2017)
Abstract In cardiac myocytes, an enhancement of late sodium current (INaL) under pathological conditions is known to cause prolongation of action potential duration (APD). This study investigated the contribution of INaL under basal, physiological co
Externí odkaz:
https://doaj.org/article/a0b04be9030b47258ed401aba4d49130
Autor:
Gaetano Thiene, Leander Beekman, Sridharan Rajamani, Adrián Ruiz-Villalba, Antonius Baartscheer, Carol Ann Remme, Gerard A Marchal, Ingeborg van der Made, Esther E. Creemers, Mathilde R. Rivaud, Cristina Basso, Connie R. Bezzina, Toon A.B. van Veen, John A. Jansen, Luiz Belardinelli, Rianne Wolswinkel
Publikováno v:
Europace
EP Europace, 22(10), 1579-1589. Oxford University Press
EP Europace, 22(10), 1579-1589. Oxford University Press
Aims SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) conduction slowing which may co
Autor:
Richard L. Verrier, Luiz Belardinelli
Publikováno v:
Journal of Cardiovascular Pharmacology
Pharmacologic management of atrial fibrillation (AF) is a pressing problem. This arrhythmia afflicts >5 million individuals in the United States and prevalence is estimated to rise to 12 million by 2050. Although the pill-in-the-pocket regimen for se
Autor:
Harry J.G.M. Crijns, Arif Elvan, Ype S. Tuininga, Erik Badings, Aaf Kuijper, Jonas De Jong, Mark Y. Lee, Dirk Schellings, Isabelle C. Van Gelder, A. John Camm, Jeremy N. Ruskin, Peter R. Kowey, Prashanti Madhavapeddi, Christopher Dufton, Luiz Belardinelli
Publikováno v:
Heart Rhythm. 19:S311-S312
Publikováno v:
Journal of molecular and cellular cardiology
It is imperative to develop better approaches to predict how antiarrhythmic drugs with multiple interactions and targets may alter the overall electrical and/or mechanical function of the heart. Safety Pharmacology studies have provided new insights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963a18ae384b7c3ab0944969c70ffc81
https://escholarship.org/uc/item/7px345mf
https://escholarship.org/uc/item/7px345mf
Autor:
Yejia Song, Luiz Belardinelli
Publikováno v:
Journal of Applied Physiology. 125:1329-1338
Aging hearts have prolonged QT interval and are vulnerable to oxidative stress. Because the QT interval indirectly reflects the action potential duration (APD), we examined the hypotheses that 1) the APD of ventricular myocytes increases with age; 2)
Autor:
Felipe R. Monteiro, Richard L. Verrier, Ana B. Rabêlo Evangelista, Luiz Belardinelli, Bruce D. Nearing
Publikováno v:
Heart rhythm. 18(8)
Background The negative inotropic effect of Class IC antiarrhythmic drugs limits their use for acute cardioversion of atrial fibrillation (AF). Objective The purpose of this study was to examine, in an intact porcine model, the effects of pulmonary a