PD-L1+ Regulatory B Cells Are Significantly Decreased in Rheumatoid Arthritis Patients and Increase After Successful Treatment

Autor: Maria C. Taboada Bonfanti, Isaac I. Cadile, Carolina Lucia Montes, Sergio Manuel Alonso, Estefanía Zacca, Luisina Inés Onofrio, Maria I. Stancich, Adriana Gruppi, Eduardo Mussano, María Cecilia Ramello, Eva Virginia Acosta Rodriguez, Laura Onetti, Paola Virginia Ferrero, Cristina del Valle Acosta

Publikováno v: Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology, Vol 9 (2018)

Background: B cells play an important role in the development and maintenance of rheumatoid arthritis (RA). Although IL-10-producing B cells represent a major subset of regulatory B cells (Bregs) able to suppress autoimmune and inflammatory responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faea3989e63cf75ead5b504b2e7e8b6
http://europepmc.org/articles/PMC6174216

NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection

Autor: Luisina Inés Onofrio, Cintia Díaz-Luján, Susana Gea, Patricia Verónica Gonzalez, Eugenio A Carrera-Silva, Augusto Fabián Paroli, Alfredo R. Arocena, Roxana Carolina Cano

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology

Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d608d56c5762e3a3de794b06e22e9344
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00913/full

Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders

Autor: Marta Cecilia Andrada, Augusto Fabián Paroli, Luisina Inés Onofrio, María Eugenia Cabalén, Susana Gea, Roxana Carolina Cano, Alfredo R. Arocena

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003464 (2015)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases

Background The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. Methodology/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a110e0f0b9fe295e86c65938ffabf677
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003464