Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Luise A Cullen-McEwen"'
Autor:
Stacey Hokke, Victor G Puelles, James A Armitage, Karen Fong, John F Bertram, Luise A Cullen-McEwen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161578 (2016)
Increasing consumption of a high fat 'Western' diet has led to a growing number of pregnancies complicated by maternal obesity. Maternal overnutrition and obesity have health implications for offspring, yet little is known about their effects on offs
Externí odkaz:
https://doaj.org/article/3199ef7f01cf420ab6829c4edaa3208e
Publikováno v:
Image Analysis and Stereology, Vol 21, Iss 1, Pp 37-41 (2011)
The normal human adult kidney contains between 300,000 and 1 million nephrons (the functional units of the kidney). Nephrons develop at the tips of the branching ureteric duct, and therefore ureteric duct branching morphogenesis is critical for norma
Externí odkaz:
https://doaj.org/article/9a5960543f5a46be8dd879a3c5775c90
Autor:
Stacey N Hokke, James A Armitage, Victor G Puelles, Kieran M Short, Lynelle Jones, Ian M Smyth, John F Bertram, Luise A Cullen-McEwen
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58243 (2013)
There is strong evidence from human and animal models that exposure to maternal hyperglycemia during in utero development can detrimentally affect fetal kidney development. Notwithstanding this knowledge, the precise effects of diabetic pregnancy on
Externí odkaz:
https://doaj.org/article/354f71efdc2e42c79410921dbb514e3b
Autor:
Natasha de Zoysa, Kotaro Haruhara, David J. Nikolic-Paterson, Peter G. Kerr, Jonathan Ling, Sarah E. Gazzard, Victor G. Puelles, John F. Bertram, Luise A. Cullen-McEwen
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatment is vari
Externí odkaz:
https://doaj.org/article/f1b0d3151ef243659d08ba006db972f9
Autor:
Sarah E. Gazzard, James van derWolde, Kotaro Haruhara, John F. Bertram, Luise A. Cullen‐McEwen
Publikováno v:
Physiological Reports, Vol 11, Iss 2, Pp n/a-n/a (2023)
Abstract Podocytes are terminally differentiated epithelial cells in glomeruli. Podocyte injury and loss are features of many diseases leading to chronic kidney disease (CKD). The developmental origins of health and disease hypothesis propose an adve
Externí odkaz:
https://doaj.org/article/18ac95c04e244e469569f1956d50ba2d
Autor:
Ryan J. Wood-Bradley, Sarah L. Henry, Roger G. Evans, John F. Bertram, Luise A. Cullen-McEwen, James A. Armitage
Publikováno v:
Journal of Developmental Origins of Health and Disease. 14:426-436
Maternal protein restriction is often associated with structural and functional sequelae in offspring, particularly affecting growth and renal-cardiovascular function. However, there is little understanding as to whether hypertension and kidney disea
Autor:
Kotaro Haruhara, Go Kanzaki, Takaya Sasaki, Saeko Hatanaka, Yusuke Okabayashi, Victor G. Puelles, Ian S. Harper, Akira Shimizu, Luise A. Cullen-McEwen, Nobuo Tsuboi, Takashi Yokoo, John F. Bertram
Publikováno v:
Kidney International. 102:1127-1135
Podocyte loss and resultant nephron loss are common processes in the development of glomerulosclerosis and chronic kidney disease. While the cortical distribution of glomerulosclerosis is known to be non-uniform, the relationship between the numbers
Autor:
James van der Wolde, Kotaro Haruhara, Victor G. Puelles, David Nikolic-Paterson, John F. Bertram, Luise A. Cullen-McEwen
Publikováno v:
Cell and Tissue Research. 388:439-451
Progressive podocyte loss is a feature of healthy ageing. While previous studies have reported age-related changes in podocyte number, density and size and associations with proteinuria and glomerulosclerosis, few studies have examined how the respon
Autor:
James W. van der Wolde, Victor G. Puelles, Luise A. Cullen-McEwen, James A. Armitage, Jan Czogalla, Fabian Haas, Kotaro Haruhara, Leon Tribolet, Yusuke Okabayashi, John F. Bertram, John P. Dowling, Wendy E. Hoy, M. Jane Black, Robert De Matteo, Michael G. Bertram
Publikováno v:
American Journal of Physiology-Renal Physiology. 321:F322-F334
The present study shows, for the first time, that low birth weight as a result of maternal nutrition is associated with low podocyte endowment. However, a mild podocyte deficit at birth did not result in glomerular pathology in adulthood. In contrast
Autor:
James A. Armitage, Sanna Barrand, Anais Giot, John F. Bertram, Ryan J. Wood-Bradley, Luise A. Cullen-McEwen, Sarah L. Henry, Luke Eipper
Publikováno v:
The Anatomical Record. 303:2657-2667
A maternal low protein (LP) diet in rodents often results in low nephron endowment and renal pathophysiology in adult life, with outcomes often differing between male and female offspring. Precisely how a maternal LP diet results in low nephron endow