Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Luisa Ponzoni"'
Autor:
Stefania Beretta, Laura Gritti, Luisa Ponzoni, Paolo Scalmani, Massimo Mantegazza, Mariaelvina Sala, Chiara Verpelli, Carlo Sala
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-22 (2022)
Abstract Background Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (NaV1.1), that causes imbalance
Externí odkaz:
https://doaj.org/article/2d0036ea25774692aeaf9f3bcfa30cad
Autor:
Carla Liaci, Mattia Camera, Valentina Zamboni, Gabriella Sarò, Alessandra Ammoni, Elena Parmigiani, Luisa Ponzoni, Enis Hidisoglu, Giuseppe Chiantia, Andrea Marcantoni, Maurizio Giustetto, Giulia Tomagra, Valentina Carabelli, Federico Torelli, Mariaelvina Sala, Yuchio Yanagawa, Kunihiko Obata, Emilio Hirsch, Giorgio R. Merlo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
GTPases of the Rho family are components of signaling pathways linking extracellular signals to the control of cytoskeleton dynamics. Among these, RAC1 plays key roles during brain development, ranging from neuronal migration to neuritogenesis, synap
Externí odkaz:
https://doaj.org/article/7f6ab99d484c4bf587fe50b38a8dbf72
Autor:
Luca Franchini, Jennifer Stanic, Luisa Ponzoni, Manuela Mellone, Nicolò Carrano, Stefano Musardo, Elisa Zianni, Guendalina Olivero, Elena Marcello, Anna Pittaluga, Mariaelvina Sala, Camilla Bellone, Claudia Racca, Monica Di Luca, Fabrizio Gardoni
Publikováno v:
iScience, Vol 19, Iss , Pp 927-939 (2019)
Summary: NMDA receptor (NMDAR) subunit composition plays a pivotal role in synaptic plasticity at excitatory synapses. Still, the mechanisms responsible for the synaptic retention of NMDARs following induction of plasticity need to be fully elucidate
Externí odkaz:
https://doaj.org/article/470e01bf96084f6180e788744e36a6ca
Autor:
Lara Pizzamiglio, Elisa Focchi, Clara Cambria, Luisa Ponzoni, Silvia Ferrara, Francesco Bifari, Genni Desiato, Nicoletta Landsberger, Luca Murru, Maria Passafaro, Mariaelvina Sala, Michela Matteoli, Elisabetta Menna, Flavia Antonucci
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Impairment of the GABAergic system has been reported in epilepsy, autism, attention deficit hyperactivity disorder, and schizophrenia. We recently demonstrated that ataxia telangiectasia mutated (ATM) directly shapes the development of the GABAergic
Externí odkaz:
https://doaj.org/article/b9f62349857e4ce28e30a250364f0897
Autor:
Luca Murru, Luisa Ponzoni, Anna Longatti, Sara Mazzoleni, Giorgia Giansante, Silvia Bassani, Mariaelvina Sala, Maria Passafaro
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105189- (2021)
Mutations in the TM4SF2 gene, which encodes TSPAN7, cause a severe form of intellectual disability (ID) often comorbid with autism spectrum disorder (ASD). Recently, we found that TM4SF2 loss in mice affects cognition. Here, we report that Tm4sf2−/
Externí odkaz:
https://doaj.org/article/b256e8940cbf477a9c99575d2b083f48
Autor:
Valentina Zamboni, Maria Armentano, Gaia Berto, Elisa Ciraolo, Alessandra Ghigo, Donatella Garzotto, Alessandro Umbach, Ferdinando DiCunto, Elena Parmigiani, Marina Boido, Alessandro Vercelli, Nadia El-Assawy, Alessandro Mauro, Lorenzo Priano, Luisa Ponzoni, Luca Murru, Maria Passafaro, Emilio Hirsch, Giorgio R. Merlo
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function mutations in RAC1 and other genes of the Rac signaling pathway have been implicated in the pathogenesis of Inte
Externí odkaz:
https://doaj.org/article/638ec94828f043b0b3fe8bf5f8131542
Autor:
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G. Smart, Maria Passafaro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiet
Externí odkaz:
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0
Autor:
Martina Casati, Andrea Saul Costa, Daniele Capitanio, Luisa Ponzoni, Evelyn Ferri, Simone Agostini, Elisa Lori
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Sarcopenia, the progressive loss of muscle mass and strength, is one of the major health issues in older adults, given its high prevalence accompanied by huge clinical and socioeconomic implications. Age-related changes in skeletal muscle can be attr
Externí odkaz:
https://doaj.org/article/4f5163a34e964f86be59bc73ea29cb57
Autor:
Micaela Tirri, Luisa Ponzoni, Sabrine Bilel, Raffaella Arfè, Daniela Braida, Mariaelvina Sala, Matteo Marti
Publikováno v:
Brain Sciences, Vol 10, Iss 9, p 586 (2020)
The drastic increase in hallucinogenic compounds in illicit drug markets of new psychoactive substances (NPS) is a worldwide threat. Among these, 2, 5-dimetoxy-4-bromo-amphetamine (DOB) and paramethoxyamphetamine (PMA; marketed as “ecstasy”) are
Externí odkaz:
https://doaj.org/article/0ffe1fefd56043dcbc3e720f422bf756
Publikováno v:
Frontiers in Psychiatry, Vol 8 (2017)
3,4-Methylenedioxymethamphetamine (MDMA) and its derivatives, 2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA), are recreational drugs whose pharmacological effects have recently been attributed to serotonin 5HT2
Externí odkaz:
https://doaj.org/article/e08cfd8d5cd7411b83c88519dc0cbe57