Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Luisa Mosti"'
Publikováno v:
Journal of Molecular Modeling. 16:677-691
Novel classes of CB2 agonists based on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over CB1. A computational study of comparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1c7efcf5d293f0b51fe734359646e9
https://doi.org/10.1007/s00894-009-0580-4
https://doi.org/10.1007/s00894-009-0580-4
Autor:
Mario Di Braccio, Debora Bruzzese, Giancarlo Grossi, Paola Fossa, Daniela Piras, Giuliana Leoncini, Maria Grazia Signorello, Giorgio Roma, Luisa Mosti
Publikováno v:
Journal of Medicinal Chemistry. 50:2886-2895
The synthesis and in vitro antiplatelet activity significant data of coumarin derivatives 5i-x and quinolin-2(1H)-one derivatives 22a,b, as well as the corresponding structure-activity relationships are described. The recently reported 8-methyl-4-(1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66081d7ea6334d1d25c323a81ebaec93
https://doi.org/10.1021/jm0611511
https://doi.org/10.1021/jm0611511
Autor:
Angelo Ranise, Francesco Bondavalli, Chiara Casolino, Silvia Schenone, Luisa Mosti, Michele Forina, Paola Fossa
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1348-1363
In this paper, we are presenting a quantitative-structure–activity relationship (QSAR) study performed on 21 selective A 1 adenosine receptor agonists plus the endogenous substrate, adenosine, so as to identify those predictors which play a key rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ba1d9e8126802c63547c1c08d796e
https://doi.org/10.1016/j.bmc.2005.09.058
https://doi.org/10.1016/j.bmc.2005.09.058
Autor:
Paola Fossa, Angelo Carotti, Cosimo Altomare, Saverio Cellamare, Modesto de Candia, Luisa Mosti
Publikováno v:
European Journal of Pharmaceutical Sciences. 26:78-86
The pH-dependent distribution profiles of a series of pyridin-2(1H)-one analogs of the inotropic/vasodilator agent milrinone, determined in 1-octanol/water (and for a number of them also in chloroform–water) using a pH-metric technique, showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7623203f6f7e6245749776ea39412e15
https://doi.org/10.1016/j.ejps.2005.05.001
https://doi.org/10.1016/j.ejps.2005.05.001
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:1393-1402
A series of 2,1,3- and 1,2,4-benzothiadiazine derivatives (BTDs) were synthesized and evaluated for their inhibitory activity versus enzymatic isoforms PDE3, PDE4 and PDE7. The compounds characterized by the 3,5-di-tert-butyl-4-hydroxybenzyl moiety a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc778c0636c5b811689511702322931
https://doi.org/10.1016/j.bmc.2004.10.055
https://doi.org/10.1016/j.bmc.2004.10.055
Autor:
Silvia Schenone, Paola Fossa, Maurizio Botta, Marina Ziche, Giulia Menozzi, Luisa Mosti, Fabrizio Manetti, Francesco Bondavalli, Olga Bruno, Annalisa Santoro, Angelo Ranise, Sandra Donnini
Publikováno v:
European Journal of Medicinal Chemistry. 39:939-946
Synthesis and biological evaluation of a new class of 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives are reported. A preliminary cellular assay system using the tumor cell line A431 responding to epidermal growth factor (EGF) for its growth,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5dcb42fe32f1ce6c86cf8fc55aa13b
https://doi.org/10.1016/j.ejmech.2004.07.010
https://doi.org/10.1016/j.ejmech.2004.07.010
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 367:109-118
Two mechanisms are responsible for the positive inotropic effect of the cardiotonic drug milrinone, i.e., inhibition of type III cAMP phosphodiesterase (PDE III), and displacement of endogenous adenosine from A(1) inhibitory receptor. Since PDE III i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523045386ff0528fc5fd0aa9904fc1fd
https://doi.org/10.1007/s00210-002-0675-2
https://doi.org/10.1007/s00210-002-0675-2
Autor:
Angelo Ranise, Luisa Mosti, Fabrizio Giordanetto, Francesco Bondavalli, Giulia Menozzi, Silvia Schenone, Paola Fossa
Publikováno v:
Journal of Computer-Aided Molecular Design. 17:39-51
Adenosine is a naturally occurring purine nucleoside that has a wide variety of well-documented regulatory functions and physiological roles. Selective activation of the adenosine A1 receptor has drawn attention in drug discovery for the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c1bdfb635fa806e5de1e1914ace8074
https://doi.org/10.1023/a:1024530029922
https://doi.org/10.1023/a:1024530029922
Publikováno v:
Journal of Computer-Aided Molecular Design. 17:53-64
In PUVA (Psoralen plus UVA) chemotherapy 8-methoxypsoralen is the most widely used compound, although its efficacy is endowed with undesired side effects. In order to have an evident anti-proliferative activity with a reduced phototoxicity, many line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d0bf8da6c875cfda48de064899134d
https://doi.org/10.1023/a:1024557113083
https://doi.org/10.1023/a:1024557113083
Autor:
Marianna Angiola, M. Ghia, A. Piana, U. Armani, Luisa Merello, Giulia Menozzi, Francesca Mattioli, Luisa Mosti
Publikováno v:
Il Farmaco. 55:219-226
A number of 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1 H -pyrazol-4-yl)butan-1-ols 2a – n were synthesized and tested in vivo for anti-inflammatory and analgesic activities and in vitro for platelet anti-aggregating activity. Dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928461d1b6b9a49e5b9db42354e25790
https://doi.org/10.1016/s0014-827x(00)00007-0
https://doi.org/10.1016/s0014-827x(00)00007-0