Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Luisa Materia"'
Autor:
Sebastiano Intagliata, Mohamed A. Helal, Luisa Materia, Valeria Pittalà, Loredana Salerno, Agostino Marrazzo, Alfredo Cagnotto, Mario Salmona, Maria N. Modica, Giuseppe Romeo
Publikováno v:
Molecules, Vol 25, Iss 8, p 1851 (2020)
The synthesis of seventeen new 1,3-diaryl-5-oxo-proline derivatives as endothelin receptor (ETR) ligands is described. The structural configuration of the new molecules was determined by analyzing selected signals in proton NMR spectra. In vitro bind
Externí odkaz:
https://doaj.org/article/bea42ffd7ea541c09893c83428795770
Autor:
Luisa Materia, Giuseppe Romeo, Alfredo Cagnotto, Loredana Salerno, Maria N. Modica, Valeria Pittalà, Mario Salmona, Sebastiano Intagliata, Agostino Marrazzo, Mohamed A. Helal
Publikováno v:
Molecules
Molecules, Vol 25, Iss 1851, p 1851 (2020)
Volume 25
Issue 8
Molecules, Vol 25, Iss 1851, p 1851 (2020)
Volume 25
Issue 8
The synthesis of seventeen new 1,3-diaryl-5-oxo-proline derivatives as endothelin receptor (ETR) ligands is described. The structural configuration of the new molecules was determined by analyzing selected signals in proton NMR spectra. In vitro bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61340eeccdb795e9e38f0c6ee5c3e241
http://hdl.handle.net/20.500.11769/413130
http://hdl.handle.net/20.500.11769/413130
Autor:
Kenneth P. Minneman, Maria Angela Siracusa, Maurizio Botta, Loredana Salerno, Luisa Materia, Valeria Pittalà, Fabrizio Manetti, Giuseppe Romeo, Maria N. Modica
Publikováno v:
European Journal of Medicinal Chemistry. 46:2676-2690
A number of new 4-phenylpiperidine-2,6-diones bearing at the 1-position an ω-[4-(substituted phenyl)piperazin-1-yl]alkyl moiety were designed and synthesized as ligands for the α1-adrenergic receptor (α1-AR) subtypes. Some synthesized compounds, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5a3dc3c60472225ee53938683245e3
https://doi.org/10.1016/j.ejmech.2011.03.054
https://doi.org/10.1016/j.ejmech.2011.03.054
Autor:
Kenneth P. Minneman, Giuseppe Romeo, Gabriella Marucci, Valeria Pittalà, Maria Angela Siracusa, Maria N. Modica, Piero Angeli, Luisa Materia, Loredana Salerno, Michela Buccioni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6200-6203
A number of new pyrimido[5,4-b]indole and [1]benzothieno[3,2-d]pyrimidine derivatives were synthesized and evaluated for their binding and functional properties at alpha(1)-adrenergic receptor (alpha(1)-AR) subtypes. They behaved as potent alpha(1)-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012f8e31865088c822ec2f6dda73d282
https://doi.org/10.1016/j.bmcl.2006.09.034
https://doi.org/10.1016/j.bmcl.2006.09.034
Autor:
Ilario Mereghetti, Filippo Russo, Maria N. Modica, Luisa Materia, Loredana Salerno, Alfredo Cagnotto, Giuseppe Romeo, M. A. Siracusa, Valeria Pittalà
Publikováno v:
Il Farmaco. 60:711-720
Endothelins (ETs) are the most ubiquitous, highly potent and unusually long-lasting peptidic constrictors of human vessels known. Elevated levels of the plasma concentration of ETs were observed in several diseases such as hypertension, acute myocard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935b5d238839bf4cf01ad7c524686eef
https://doi.org/10.1016/j.farmac.2005.06.005
https://doi.org/10.1016/j.farmac.2005.06.005
Autor:
Luisa Materia, Ilario Mereghetti, Filippo Russo, Alfredo Cagnotto, Giuseppe Romeo, Loredana Salerno, Maria N. Modica, Valeria Pittalà, Maria Angela Siracusa
Publikováno v:
Il Farmaco. 60:731-738
Endothelin-1 (ET-1), a peptide of 21 amino acid residues, is the most potent vasoconstrictor substance known and now it is understood to be one of a family of three mammalian vasoactive peptides that also includes ET-2 and ET-3. The endothelins (ETs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da30a6067d2bad2147d385e9d976054b
https://doi.org/10.1016/j.farmac.2005.06.010
https://doi.org/10.1016/j.farmac.2005.06.010
Autor:
Filippo Russo, Róbert Gáspár, Luisa Materia, Giuseppe Romeo, Maria N. Modica, Ferenc Fülöp, Tiziana Mennini, Alfredo Cagnotto, George Falkay
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:3891-3901
This work reports on the synthesis and affinities for the 5-HT(3) versus the 5-HT(4) receptor of new piperazinyl-substituted thienopyrimidine derivatives 20-45 with a view to identify potent and selective ligands for the 5-HT(3) receptor. Some of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bff11169c53e23bd51d3a2c51d706a
https://doi.org/10.1016/j.bmc.2004.04.043
https://doi.org/10.1016/j.bmc.2004.04.043
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:619-637
α1-Adrenergic receptors (α1-ARs) belong to the seven-transmembrane-domain receptor superfamily and play a primary role in the regulation of several physiological processes, particularly in the cardiovascular system. Three different α1-AR subtypes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d30b488a9766fc08671841fff3d281
https://doi.org/10.1517/13543776.14.5.619
https://doi.org/10.1517/13543776.14.5.619
Autor:
Kenneth P. Minneman, Gabriella Marucci, Luisa Materia, Giuseppe Romeo, Michela Buccioni, Valeria Pittalà, Maria N. Modica, Maria Angela Siracusa, Loredana Salerno
Publikováno v:
European journal of medicinal chemistry. 83
A new series of high affinity ligands and antagonists for the α1D-adrenergic receptor (AR) has been discovered. New molecules present a [1]benzothieno[3,2-d]pyrimidin-2,4(1H,3H)-dione or a [1]benzothieno[3,2-d]pyrimidin-4(3H)-one scaffold and bear a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81a00117c88ea91d782276d3cca3f06
https://pubmed.ncbi.nlm.nih.gov/24992070
https://pubmed.ncbi.nlm.nih.gov/24992070
Autor:
Giuseppe, Romeo, Luisa, Materia, Maria N, Modica, Valeria, Pittalà, Loredana, Salerno, Maria A, Siracusa, Fabrizio, Manetti, Maurizio, Botta, Kenneth P, Minneman
Publikováno v:
European journal of medicinal chemistry. 46(7)
A number of new 4-phenylpiperidine-2,6-diones bearing at the 1-position an ω-[4-(substituted phenyl)piperazin-1-yl]alkyl moiety were designed and synthesized as ligands for the α(1)-adrenergic receptor (α(1)-AR) subtypes. Some synthesized compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8467b84a82a85385e22e6ecc89a60e9c
https://pubmed.ncbi.nlm.nih.gov/21514979
https://pubmed.ncbi.nlm.nih.gov/21514979