Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Luisa Guerrini"'
Autor:
Roberto Quadri, Giuseppe Rotondo, Sarah Sertic, Sara Pozzi, Maria Chiara dell’Oca, Luisa Guerrini, Marco Muzi-Falconi
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108011- (2023)
Summary: Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not only mediate chromosome segregation, but also defines the axis of cellular division
Externí odkaz:
https://doaj.org/article/0a2fd4c198e24d8699dbd1d55d15f1d5
Autor:
Mariano Francesco Caratozzolo, Flaviana Marzano, Daniela Isabel Abbrescia, Francesca Mastropasqua, Vittoria Petruzzella, Viola Calabrò, Graziano Pesole, Elisabetta Sbisà, Luisa Guerrini, Apollonia Tullo
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis. The stability of the p53 tumor s
Externí odkaz:
https://doaj.org/article/cba4e64698044998bd6b556b92ff64f8
Publikováno v:
Cells, Vol 10, Iss 3, p 561 (2021)
The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In this review, we analyze the regulation of TRIM8 gene expressi
Externí odkaz:
https://doaj.org/article/bab72e07315c4546ac3c905b8623e18c
Autor:
Maxence Vieux-Rochas, Kamal Bouhali, Stefano Mantero, Giulia Garaffo, Paolo Provero, Simonetta Astigiano, Ottavia Barbieri, Mariano F Caratozzolo, Apollonia Tullo, Luisa Guerrini, Yvan Lallemand, Benoît Robert, Giovanni Levi, Giorgio R Merlo
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51700 (2013)
The Dlx and Msx homeodomain transcription factors play important roles in the control of limb development. The combined disruption of Msx1 and Msx2, as well as that of Dlx5 and Dlx6, lead to limb patterning defects with anomalies in digit number and
Externí odkaz:
https://doaj.org/article/4d2c0b171d794b4e9ab89ab1cf4c6ae8
Autor:
Teresa Lopardo, Nadia Lo Iacono, Barbara Marinari, Maria L Giustizieri, Daniel G Cyr, Giorgio Merlo, Francesca Crosti, Antonio Costanzo, Luisa Guerrini
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2715 (2008)
The epidermis of the skin is a self-renewing, stratified epithelium that functions as the interface between the human body and the outer environment, and acts as a barrier to water loss. Components of intercellular junctions, such as Claudins, are cr
Externí odkaz:
https://doaj.org/article/681b7006a81747fda121c583ca1c4fa9
Autor:
Alessandra Amendolare, Flaviana Marzano, Vittoria Petruzzella, Rosa Anna Vacca, Luisa Guerrini, Graziano Pesole, Elisabetta Sbisà, Apollonia Tullo
Publikováno v:
Cancers. 14:5733
The TP53 tumor suppressor gene is known as the guardian of the genome, playing a pivotal role in controlling genome integrity, and its functions are lost in more than 50% of human tumors due to somatic mutations. This percentage rises to 90% if mutat
Autor:
Junichi Yamamoto, Nobuyuki Shimizu, Takumi Ito, Luisa Guerrini, Marco De Simone, Tomomi Sato, Yuki Yamaguchi, Hideki Ando, Hiroshi Handa, Kazuhide Asakawa, Tomoko Asatsuma-Okumura
Publikováno v:
Nature chemical biology. 15(11)
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic and antimyeloma activities. CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specifi
Autor:
Alessandra Pollice, Viola Calabrò, Marco De Simone, Girolama La Mantia, Maria Vivo, Luisa Guerrini, Michela Ranieri
Publikováno v:
Gene. 645
ΔNp63α is finely and strictly regulated during embryogenesis and differentiation. ΔNp63α is the only p63 isoform degraded by the proteasome after Ubiquitin and SUMO (Small Ubiquitin-like MOdifier) conjugation. Here, we show that p63 ubiquitylatio
Autor:
Francesca Mastropasqua, Apollonia Tullo, Mariano Francesco Caratozzolo, Italia Aiello, Annalisa Morgano, Flaviana Marzano, Luisa Guerrini, Elisabetta Sbisà, Antonio Moschetta, Elena Ranieri, Graziano Pesole, Giuseppe Gasparre, Alessio Valletti, Giuseppe Di Tullio, Sabino Liuni
Publikováno v:
Molecular cancer 16 (2017). doi:10.1186/s12943-017-0634-7
info:cnr-pdr/source/autori:Mastropasqua, Francesca; Marzano, Flaviana; Valletti, Alessio; Aiello, Italia; Di Tullio, Giuseppe; Morgano, Annalisa; Liuni, Sabino; Ranieri, Elena; Guerrini, Luisa; Gasparre, Giuseppe; Sbisa, Elisabetta; Pesole, Graziano; Moschetta, Antonio; Caratozzolo, Mariano Francesco; Tullo, Apollonia/titolo:TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours/doi:10.1186%2Fs12943-017-0634-7/rivista:Molecular cancer/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:16
Molecular Cancer
info:cnr-pdr/source/autori:Mastropasqua, Francesca; Marzano, Flaviana; Valletti, Alessio; Aiello, Italia; Di Tullio, Giuseppe; Morgano, Annalisa; Liuni, Sabino; Ranieri, Elena; Guerrini, Luisa; Gasparre, Giuseppe; Sbisa, Elisabetta; Pesole, Graziano; Moschetta, Antonio; Caratozzolo, Mariano Francesco; Tullo, Apollonia/titolo:TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours/doi:10.1186%2Fs12943-017-0634-7/rivista:Molecular cancer/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:16
Molecular Cancer
Background TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba8d9110414abbcc69b9742832ae9d8
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0634-7
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0634-7
Autor:
Andrea Prodosmo, Silvia Soddu, Armando Bartolazzi, Antonio Costanzo, Francesca Siepi, Luisa Guerrini, M Gentileschi, Francesco Galli, Cinzia Rinaldo, Ada Sacchi, Chiara Lazzari
Publikováno v:
Oncogene. 30:4802-4813
Homeodomain-interacting protein kinase 2 (HIPK2) is an emerging player in cell response to genotoxic agents that senses damage intensity and contributes to the cell's choice between cell cycle arrest and apoptosis. Phosphorylation of p53 at S46, an a