Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Luisa Carrara"'
1
HER2/neu gene amplification determines the sensitivity of uterine serous carcinoma cell lines to AZD8055, a novel dual mTORC1/2 inhibitor
Autor: Thomas J. Rutherford, Dana M. Roque, Diana P. English, Peter E. Schwartz, Salvatore Lopez, Luisa Carrara, Emiliano Cocco, Ileana Bortolomai, Alessandro D. Santin, Stefania Bellone
Publikováno v: Gynecologic Oncology. 131:753-758
Objective To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af52377a8c6815d8e4203ab1c05b7ba
https://doi.org/10.1016/j.ygyno.2013.08.033
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2
Expression of αV-Integrins in Uterine Serous Papillary Carcinomas; Implications for Targeted Therapy With Intetumumab (CNTO 95), a Fully Human Antagonist Anti-αV-Integrin Antibody
Autor: Luisa Carrara, Federica Guzzo, Emiliano Cocco, Joyce Varughese, Stefania Bellone, Thomas J. Rutherford, Deborah J. Marshall, Alessandro D. Santin, K. ElSahwi, Peter E. Schwartz, Marta Bellone, Paola Todeschini, Sergio Pecorelli
Publikováno v: International Journal of Gynecological Cancer. 21:1084-1090
Objective: Uterine serous papillary carcinoma (USPC) is an aggressive variant of endometrial cancer characterized by an innate resistance to chemotherapy and poor prognosis. In this study, we evaluated the expression of αV-integrins in primary USPC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4827cafd09e5c4e18fbf0f8964dc6d3e
https://doi.org/10.1097/igc.0b013e3182187324
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3
Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor
Autor: Emiliano Cocco, Charles J. Lockwood, Marta Bellone, Ken Yu Lin, Thomas J. Rutherford, Masoud Azodi, Peter E. Schwartz, Natalia Buza, Luisa Carrara, Sergio Pecorelli, Joyce Varughese, Paola Todeschini, Dan-Arin Silasi, Stefania Bellone, Alessandro D. Santin, Renata A. Tassi
Publikováno v: Clinical & Experimental Metastasis. 28:689-700
We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2391d32e0d738e487e7555405604ee
https://doi.org/10.1007/s10585-011-9401-0
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6
Could Different Follow-Up Modalities Play a Role in the Diagnosis of Asymptomatic Endometrial Cancer Relapses?: An Italian Multicentric Retrospective Analysis
Autor: Luca Fuso, L Galletto, Luisa Carrara, Giovanni Scambia, Enrico Sartori, Fabio Landoni, Angiolo Gadducci, Andrea Lissoni, Paolo Zola, Tiziano Maggino
ObjectiveTo determine current practice and to assess the value of routine follow-up procedures for endometrial cancer surveillance. To discuss whether such procedures are feasible and effective to identify asymptomatic recurrences and describe the pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6d6480f0586affad603d4f93f1167b
http://hdl.handle.net/2318/115788
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7
HER2/neu as a potential target for immunotherapy in gynecologic carcinosarcomas
Autor: Emiliano Cocco, Roberto Angioli, Paola Todeschini, Sara Gasparrini, Peter E. Schwartz, Thomas J. Rutherford, Stefania Bellone, Alessandro D. Santin, Joyce Varughese, Sergio Pecorelli, Luisa Carrara, Federica Guzzo, Natalia Buza, Marta Betti, Pei Hui
Carcinosarcomas of the female genital tract are rare tumors with an aggressive clinical behavior. Trastuzumab, a humanized monoclonal antibody, acts by binding to HER2/neu extracellular domain and exhibits therapeutic efficacy in HER2/neu-overexpress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40580f778fb6925513d157fb12de23f
http://hdl.handle.net/11379/457290
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9
Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab
Autor: Peter E. Schwartz, Pei Hui, Sergio Pecorelli, Emiliano Cocco, Joyce Varughese, Ken Yu Lin, Dan-Arin Silasi, Paola Todeschini, Alessandro D. Santin, Luisa Carrara, Federica Guzzo, Thomas J. Rutherford, Elena Ratner, Stefania Bellone, Masoud Azodi, Natalia Buza
Publikováno v: British Journal of Cancer
Background: We evaluated shedding of epidermal growth factor type II receptor (Her2/neu) extracellular domain (ECD) in primary uterine serous carcinoma (USC) cell lines and in the serum of USC patients and its biological effects in experiments of tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653eeaadf1f5f45b7d4aed8dbde73ebb
http://hdl.handle.net/11379/112915
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10
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcomas cell lines is linked to tubulin-beta-III expression
Autor: Luisa Carrara, Federica Guzzo, Dana M. Roque, Enrico Sartori, Stefania Bellone, Alessandro D. Santin, Thomas J. Rutherford, Peter E. Schwartz, Cocco Emiliano, Sergio Pecorelli
To compare the in vitro sensitivity/resistance to patupilone versus paclitaxel in uterine and ovarian carcinosarcomas (CS).Five primary carcinosarcoma cell lines, two from uterine and three of ovarian origin, were evaluated for growth rate and tested
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afad4ceb738b338bf69f148f499bcd4
http://hdl.handle.net/11379/112912
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