Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Luisa Carlota Lopez-Cara"'
Autor:
Romeo Romagnoli, Filippo Prencipe, Luisa Carlota Lopez-Cara, Paola Oliva, Stefania Baraldi, Pier Giovanni Baraldi, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 727-742 (2018)
The combination of two pharmacophores into a single molecule represents one of the methods that can be adopted for the synthesis of new anticancer molecules. To investigate the influence of the position of the pyridine nitrogen on biological activity
Externí odkaz:
https://doaj.org/article/c952a4ba515b4ef2aa958ab1d731b780
Autor:
Francisco José Aguilar-Troyano, Archimede Torretta, Gianluca Rubbini, Alberto Fasiolo, Pilar María Luque-Navarro, María Paz Carrasco-Jimenez, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Dolores González-Pacanowska, Emilio Parisini, Luisa Carlota Lopez-Cara
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1842 (2021)
In the fight against Malaria, new strategies need to be developed to avoid resistance of the parasite to pharmaceutics and other prevention barriers. Recently, a Host Directed Therapy approach based on the suppression of the starting materials uptake
Externí odkaz:
https://doaj.org/article/4ed42e0cc01e4a2db6f69fca8a4f731c
Publikováno v:
Crystals, Vol 10, Iss 7, p 613 (2020)
Among the malaria-causing parasites, the deadliest is Plasmodium falciparum, which accounts for the majority of the fatalities. As the infection progresses inside erythrocytes, major cellular and metabolic changes take place. For its own growth, the
Externí odkaz:
https://doaj.org/article/c336a998a0f44108866de6fbb5ebda88
Autor:
Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and ne
Externí odkaz:
https://doaj.org/article/95a6bc7fc7a345f08d833daae479ee94
Publikováno v:
Crystals, Vol 10, Iss 613, p 613 (2020)
Crystals
Volume 10
Issue 7
Crystals
Volume 10
Issue 7
Among the malaria-causing parasites, the deadliest is Plasmodium falciparum, which accounts for the majority of the fatalities. As the infection progresses inside erythrocytes, major cellular and metabolic changes take place. For its own growth, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf943d6254068d61357b48e290d21579
https://www.mdpi.com/2073-4352/10/7/613
https://www.mdpi.com/2073-4352/10/7/613
Anticancer Activity and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors
Autor:
Carmen Marco, María Kimatrai-Salvador, Pablo Ríos-Marco, Giampietro Viola, María Paz Carrasco-Jiménez, Santiago Schiaffino-Ortega, Ramon Hurtado-Guerrero, Elena Mariotto, Luisa Carlota Lopez-Cara, Pilar María Luque-Navarro
Choline kinase inhibitors are an important class of cytotoxic compounds useful for the treatment of different forms of cancer since aberrant choline metabolism is a feature of neoplastic cells. Here we present the characterization and the structure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5950e9737832d34e42bc51372e45d3ea
https://doi.org/10.20944/preprints202108.0001.v1
https://doi.org/10.20944/preprints202108.0001.v1
Autor:
Paola Oliva, Romeo Romagnoli, Elena Mariotto, Luisa Carlota Lopez-Cara, Salvatore Ferla, Maria Kimatrai Salvador, Elena Mattiuzzo, Andrea Brancale, Mariem Chayah, Filippo Prencipe, Ernest Hamel, Giampietro Viola, Roberto Ronca, Roberta Bortolozzi, Santiago Schiaffino Ortega, Stefania Baraldi, Pier Giovanni Baraldi
Publikováno v:
Journal of Medicinal Chemistry. 62:1274-1290
The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3d60e2108fe51c21f512f9adf41556
https://doi.org/10.1021/acs.jmedchem.8b01391
https://doi.org/10.1021/acs.jmedchem.8b01391
Autor:
Giampietro Viola, Ramon Hurtado-Guerrero, Carmen Marco, María Kimatrai-Salvador, Pilar María Luque-Navarro, Elena Mariotto, Luisa Carlota Lopez-Cara, Pablo Ríos-Marco, María Paz Carrasco-Jiménez, Santiago Schiaffino-Ortega
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1360, p 1360 (2021)
instname
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1360, p 1360 (2021)
This research was funded by Convocatoria 2019 Proyectos de I + D + i - RTI Tipo B "Ministerio de Innovacion y Ciencia" grant number PID2019-109294RB-I00 and University of Granada, Cei-BioticProject grant number CEI2013-MP-1.
Choline kinase inhib
Choline kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118ae8f8ccd0cb0801e411d802ec4054
http://hdl.handle.net/10481/71080
http://hdl.handle.net/10481/71080
Autor:
María Paz Carrasco-Jiménez, Emilio Parisini, Francisco José Aguilar-Troyano, Archimede Torretta, Alberto Fasiolo, Pilar María Luque-Navarro, Dolores González-Pacanowska, Luisa Carlota Lopez-Cara, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Gianluca Rubbini
Publikováno v:
Pharmaceutics
Volume 13
Issue 11
Pharmaceutics, Vol 13, Iss 1842, p 1842 (2021)
Volume 13
Issue 11
Pharmaceutics, Vol 13, Iss 1842, p 1842 (2021)
In the fight against Malaria, new strategies need to be developed to avoid resistance of the parasite to pharmaceutics and other prevention barriers. Recently, a Host Directed Therapy approach based on the suppression of the starting materials uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2db5c0d3cc79e14af33b33649d5023
https://hdl.handle.net/11585/915346
https://hdl.handle.net/11585/915346
Autor:
Carmen Marco, Giampietro Viola, Francisco Fermín Castro Navas, Gianluca Rubbini, María Paz Carrasco-Jiménez, Antonio Macchiarulo, Marco Ballarotto, Luisa Carlota Lopez-Cara, Lucía Serrán Aguilera, Ramon Hurtado-Guerrero, Elena Mariotto
Seeking for new anticancer drugs with strong antiproliferative activity and simple molecular structure, we designed a novel series of compounds based on our previous reported pharmacophore model composed of five moieties. Antiproliferative assays on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40860c8cab609a3eff021baa63773713
http://hdl.handle.net/11391/1506190
http://hdl.handle.net/11391/1506190